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SKP2 Antikörper (C-Term)

SKP2 Reaktivität: Human, Ratte, Rind (Kuh), Schwein, Pferd, Hund, Meerschweinchen, Kaninchen WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2505495
  • Target Alle SKP2 Antikörper anzeigen
    SKP2 (S-Phase Kinase-Associated Protein 2 (SKP2))
    Bindungsspezifität
    • 16
    • 10
    • 8
    • 7
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reaktivität
    • 75
    • 29
    • 28
    • 5
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Ratte, Rind (Kuh), Schwein, Pferd, Hund, Meerschweinchen, Kaninchen
    Wirt
    • 67
    • 9
    • 1
    Kaninchen
    Klonalität
    • 67
    • 9
    Polyklonal
    Konjugat
    • 47
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser SKP2 Antikörper ist unkonjugiert
    Applikation
    • 55
    • 21
    • 21
    • 18
    • 15
    • 13
    • 13
    • 13
    • 12
    • 8
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Sequenz
    TLQLLKEALP HLQINCSHFT TIARPTIGNK KNQEIWGIKC RLTLQKPSCL
    Homologie
    Cow: 100%, Dog: 92%, Guinea Pig: 83%, Horse: 92%, Human: 100%, Pig: 100%, Rabbit: 100%, Rat: 75%
    Produktmerkmale
    This is a rabbit polyclonal antibody against SKP2. It was validated on Western Blot.
    Aufreinigung
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the C-terminal region of Human SKP2
    Top Product
    Discover our top product SKP2 Primärantikörper
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeat freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    SKP2 (S-Phase Kinase-Associated Protein 2 (SKP2))
    Andere Bezeichnung
    SKP2 (SKP2 Produkte)
    Hintergrund
    This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class, in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19). In addition, this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas.
    Protein Interaction Partner: USP18, CUL1, CDKN1A, SAMHD1, SUGT1, UBC, AR, RND3, CKS1B, MYC, SMAD7, CDKN1B, SKP1, CDK3, CDK2, LATS2, FZR1, CEP192, SF3B3, KMT2A, E2F1, KPNA6, SIRT3, SIRT4, RBX1, CDC14B, NEDD8, SIRT6, KPNA1, HSP90AA1, EP300, CEBPA, CDH1, BRCA1, BARD1, BTRC, SNRPB2, CDC3
    Protein Size: 210
    Molekulargewicht
    23 kDa
    Gen-ID
    6502
    Pathways
    Mitotic G1-G1/S Phases
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