SKP2 Antikörper (C-Term)

Produktnummer ABIN2505495

Produktdetails anti-SKP2 Antikörper

Target: SKP2 (S-Phase Kinase-Associated Protein 2 (SKP2))

Bindungsspezifität: C-Term

Reaktivität: Human, Ratte, Rind (Kuh), Schwein, Pferd, Hund, Meerschweinchen, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SKP2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: TLQLLKEALP HLQINCSHFT TIARPTIGNK KNQEIWGIKC RLTLQKPSCL

Homologie: Cow: 100%, Dog: 92%, Guinea Pig: 83%, Horse: 92%, Human: 100%, Pig: 100%, Rabbit: 100%, Rat: 75%

Produktmerkmale: This is a rabbit polyclonal antibody against SKP2. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human SKP2

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeat freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu SKP2

Target: SKP2 (S-Phase Kinase-Associated Protein 2 (SKP2))

Andere Bezeichnung: SKP2 (SKP2 Produkte)

Hintergrund: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class, in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19). In addition, this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas.
Protein Interaction Partner: USP18, CUL1, CDKN1A, SAMHD1, SUGT1, UBC, AR, RND3, CKS1B, MYC, SMAD7, CDKN1B, SKP1, CDK3, CDK2, LATS2, FZR1, CEP192, SF3B3, KMT2A, E2F1, KPNA6, SIRT3, SIRT4, RBX1, CDC14B, NEDD8, SIRT6, KPNA1, HSP90AA1, EP300, CEBPA, CDH1, BRCA1, BARD1, BTRC, SNRPB2, CDC3
Protein Size: 210

Molekulargewicht: 23 kDa

Gen-ID: 6502

Pathways: Mitotic G1-G1/S Phases