NAE1 Antikörper (NEDD8 Activating Enzyme E1 Subunit 1) (Cy5)

Details for Product anti-NAE1 Antibody No. ABIN1704713
Antigen
  • APPBP1
  • CG7828
  • Dmel\\CG7828
  • anon-WO0140519.225
  • dAPP-BP1
  • dAPPBP1
  • A-116A10.1
  • ula-1
  • Appbp1
  • 59kDa
  • appbp1
  • zgc:66148
  • beta-Amyloid precursor protein binding protein 1
  • NEDD8 activating enzyme E1 subunit 1
  • NEDD8 activating enzyme E1 subunit 1 S homeolog
  • nedd8 activating enzyme E1 subunit 1
  • NEDD8-activating enzyme E1 regulatory subunit
  • APP-BP1
  • NAE1
  • Nae1
  • nae1.S
  • nae1
  • ula-1
Reaktivität
Human, Maus, Ratte (Rattus)
114
36
33
1
1
1
1
1
1
Wirt
Kaninchen
95
20
Klonalität
Polyklonal
Konjugat
Dieser NAE1 Antikörper ist konjugiert mit Cy5
6
5
5
4
4
4
2
2
2
2
2
1
1
1
1
1
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
95
48
43
16
12
3
3
1
Optionen
Immunogen KLH conjugated synthetic peptide derived from human APPBP1
Isotyp IgG
Reinigung Purified by Protein A.
Plasmids, Primers & others Plasmide, Primers & weitere NAE1 products on genomics-online (e.g. as negative or positive controls)
Antigen
Andere Bezeichnung Appbp1 (NAE1 Antibody Abstract)
Hintergrund

Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation.

Subcellular location: Cell membrane

Synonyms: HPP1, ula-1, APPBP1, A-116A10.1, NEDD8-activating enzyme E1 regulatory subunit, Amyloid beta precursor protein-binding protein 1, 59 kDa, APP-BP1, Amyloid protein-binding protein 1, Proto-oncogene protein 1, NAE1

Gen-ID 8883
UniProt Q13564
Applikations-hinweise IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung Store at 4°C
Haltbarkeit 12 months
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