Glutaredoxin 2 Antikörper (GRX2) (Cy5)

Details for Product anti-GRX2 Antibody No. ABIN1704672
Antigen
  • ECK1049
  • JW1051
  • CGI-133
  • GRX2
  • 1700010P22Rik
  • AI645710
  • Grx2
  • glutaredoxin 2 (Grx2)
  • glutaredoxin Grx2
  • thioredoxin
  • glutaredoxin 2
  • glutaredoxin 2 (thioltransferase)
  • grxB
  • grx2
  • AF_RS10790
  • GLRX2
  • Glrx2
Reaktivität
Human
62
10
9
2
2
2
2
2
2
1
Wirt
Kaninchen
52
10
Klonalität
Polyklonal
Konjugat
Dieser Glutaredoxin 2 Antikörper ist konjugiert mit Cy5
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
31
13
12
10
9
7
6
3
3
2
2
Optionen
Immunogen KLH conjugated synthetic peptide derived from human Glutaredoxin 2
Isotyp IgG
Reinigung Purified by Protein A.
Plasmids, Primers & others Plasmide, Primers & weitere Glutaredoxin 2 products on genomics-online (e.g. as negative or positive controls)
Antigen
Andere Bezeichnung Glutaredoxin 2 (GRX2 Antibody Abstract)
Hintergrund

Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release.

Subcellular location: Nucleus, Mitochondrion

Synonyms: GRX2, CGI-133, Glutaredoxin-2, mitochondrial, GLRX2

Gen-ID 51022
UniProt Q9NS18
Pathways Cell RedoxHomeostasis
Applikations-hinweise IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung Store at 4°C
Haltbarkeit 12 months
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