Glycine Dehydrogenase (GLDC) Antikörper (Cy5)

Details zu Produkt Nr. ABIN1704581
Antigen
  • PSPTO1276
  • Tb07.43M14.350
  • DDBDRAFT_0219205
  • DDBDRAFT_0231130
  • DDB_0219205
  • DDB_0231130
  • D030049L12Rik
  • D19Wsu57e
  • GCE
  • GCSP
  • HYGN1
  • fb23b05
  • wu:fb23b05
  • zgc:66198
  • gldc
  • glycine dehydrogenase (decarboxylating) GcvP
  • glycine dehydrogenase
  • glycine cleavage system P-protein
  • glycine decarboxylase
  • glycine dehydrogenase (decarboxylating)
  • glycine decarboxylase S homeolog
  • gcvP
  • Tb927.7.1910
  • Gldc
  • GLDC
  • gldc
  • gldc.S
Reaktivität
Human, Maus, Ratte (Rattus)
62
34
18
1
1
1
1
1
1
Wirt
Kaninchen
65
1
Klonalität
Polyklonal
Konjugat
Cy5
7
4
3
2
2
2
1
1
1
1
1
1
1
1
1
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
53
17
13
12
7
7
6
6
3
1
1
Optionen
Immunogen KLH conjugated synthetic peptide derived from human GLDC
Isotyp IgG
Reinigung Purified by Protein A.
Antigen
Andere Bezeichnung Gldc (GLDC Antibody Abstract)
Hintergrund

The glycine cleavage system is comprised of AMT (known as Protein T), GCSH (known as Protein H), DLD (known as Protein L) and GLDC (known as Protein P), all of which work together to catalyze the cleavage and degradation of glycine. GLDC (glycine dehydrogenase ), also known as GCE, GCSP (glycine cleavage system P protein) or HYGN1, is a 1,020 amino acid protein that localizes to the mitochondria and belongs to the gcvP family. GLDC binds to glycine and enables the methylamine group from glycine to be transferred to the Protein T. GLDC exists as a homodimer and utilizes pyridoxal phosphate as a cofactor. Mutations in the gene encoding GLDC leads to nonketotic hyperglycinemia (NKH), also known as glycine encephalopathy (GCE), an autosomal recessive disease characterized by accumulation of a large amount of glycine in body fluid and by severe neurological symptoms.

Synonyms: GCE, GCSP, GCSP_HUMAN, GLDC, Glycine cleavage system P protein, glycine cleavage system protein P, Glycine decarboxylase, glycine decarboxylase P protein, Glycine dehydrogenase decarboxylating mitochondrial, Glycine dehydrogenase [decarboxylating], mitochondrial, Gycine dehydrogenase decarboxylating, HYGN1, MGC138198, MGC138200, NKH.

Gen-ID 2731
Applikations-hinweise IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung Store at 4°C
Haltbarkeit 12 months
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