LAP2 alpha Antikörper (Cy5)

Details zu Produkt Nr. ABIN1704513
Antigen
  • CMD1T
  • LAP2
  • LEMD4
  • PRO0868
  • TP
  • 5630400D24Rik
  • AI195756
  • AI606875
  • AW214352
  • AW547477
  • thymopoietin
  • TMPO
  • Tmpo
Reaktivität
Human, Maus, Ratte (Rattus)
18
15
15
Wirt
Kaninchen
15
3
Klonalität
Polyklonal
Konjugat
Cy5
1
1
1
1
1
1
1
1
1
1
1
1
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
12
7
3
2
2
2
1
Optionen
Immunogen KLH conjugated synthetic peptide derived from human LAP2
Isotyp IgG
Reinigung Purified by Protein A.
Antigen
Hintergrund

The nuclear envelope separates the nucleoplasm from the cytoplasm in eukaryotic cells and includes the outer and inner nuclear membrane, nuclear pore complexes and the nuclear lamina. The nuclear lamina contains intermediate filament-type proteins called lamins that form a dense network to strengthen and stabilize the nuclear envelope. Lamina-associated polypeptide 2 (LAP2) is also known as thymopoietin. LAP2 is a nuclear envelope protein and contains an amino-terminal region called the LAP2-emerin-MAN1 or LEM motif. LAP2 also contains a unique DNA-binding amino-terminal domain. Alternative splicing produces six isoforms (i±, i²,i³, iμ and i´) of mammalian LAP2 and three isoforms in Xenopus LAP2. LAP2i± and LAP2i² associate with chromosomal barrier-to-autointegration factor (BAF) and may play a role in stabilizing chromatin structure. LAP2i² also binds to lamin B. LAP2i± is a non-membrane isoform of LAP2 that associates with the internal nucleoskeleton and binds lamin A. The gene encoding human LAP2 maps to chromosome 12q23.1.

Synonyms: Isoforms beta/gamma, Lamina associated polypeptide 2 alpha, Lamina associated polypeptide 2, LAP2, Thymopoietin, Thymopoietin isoform alpha, TMPO, TP alpha, TP, LAP2 alpha, LAP2A_HUMAN.

Applikations-hinweise IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung Store at 4°C
Haltbarkeit 12 months
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