CSPS (AA 201-295) Antikörper (Cy5)

Produktnummer ABIN1704475

Produktdetails

Target: CSPS

Bindungsspezifität: AA 201-295

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Cy5

Applikation: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Kreuzreaktivität: Human, Maus

Homologie: Rat,Cow,Sheep,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CSPS

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Antigendetails

Target: CSPS

Hintergrund:

Synonyms: Aryl sulfotransferase 1A3/1A4, Aryl sulfotransferase, Catecholamine Sulfating Phenol Sulfotransferase, Catecholamine-sulfating phenol sulfotransferase, Dopamine specic sulfotransferase, FLJ54864, HAST, HAST3, M PST, M-PST, Monoamine preferring sulfotransferase, Monoamine sulfating phenosulfotransferase, monoamine-preferring, Monoamine-sulfating phenol sulfotransferase, MPST, Phenol sulfotransferase 1A5, Placental estrogen sulfotransferase, ST1A3/ST1A4, ST1A3_HUMAN, ST1A5, STM, Sulfokinase, Sulfotransferase 1A3/1A4, Sulfotransferase, Sulfotransferase family cytosolic 1A phenol preferring member 3, Sulfotransferase family cytosolic 1A phenol preferring member 4, Sulfotransferase monoamine preferring, SULT1A 3, SULT1A4, Thermolabile monoamine M form phenol sulfotransferase, Thermolabile phenol sulfotransferase, TL PST, TL-PST, TLPST.

Background: Cysteine string proteins (CSPs) are synaptic vesicle-associated, secretory vesicle proteins that are involved in Ca2+-regulated exocytosis of synaptic vesicles and modulation of presynaptic transmembrane calcium fluxes in neuroendocrine and endocrine cell types. CSP contains a J-domain that binds HSP 70/HSC 70 chaperone ATPases and a membrane-targeting, palmitoylated cysteine-rich string region. CSPs may act as molecular chaperones in synapses, and mediate conformational folding of components of the vesicular exocytotic machinery. CSP is involved in the fine tuning of neurotransmission through its interaction with receptor-coupled trimeric GTP binding proteins (G proteins) and N-type Ca2+ channels. Two variants of CSP have been described: CSP1, and the 31 amino acid, C-terminally truncated isoform, CSP2. Subcellular fractionation of insulinoma cells shows CSP1 in granular fractions, while the membrane and cytosol fractions contain predominantly CSP2. The fractions also contain additional proteins, presumably CSP dimers. Furthermore, in various mammalian cell lines (including rat brain) CSP1 expression predominates CSP2 expression.

Gen-ID: 101060714