Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes.
Subcellular location: Cytoplasm, Cell membrane
Synonyms: EL52, HSPN, LAP2, HSP86, HSPC1, HSPCA, Hsp89, Hsp9, LAP-2, HSP89A, HSP9A, HSP9N, HSPCAL1, HSPCAL4, Heat shock protein HSP 9-alpha, Heat shock 86 kDa, HSP 86, Lipopolysaccharide-associated protein 2, LPS-associated protein 2, Renal carcinoma antigen NY-REN-38, HSP9AA1