HIC2 Antikörper (Hypermethylated in Cancer 2) (Cy5)

Details for Product anti-HIC2 Antibody No. ABIN1704318
Antigen
  • HIC2
  • hic2
  • MGC154932
  • HRG22
  • ZBTB30
  • ZNF907
  • AA409108
  • mKIAA1020
  • zgc:109776
  • HIC ZBTB transcriptional repressor 2
  • hypermethylated in cancer 2 L homeolog
  • hypermethylated in cancer 2
  • HIC2
  • hic2.L
  • Hic2
  • hic2
Reaktivität
Human, Maus, Ratte (Rattus)
79
54
29
11
10
8
6
6
5
3
2
2
1
1
1
Wirt
Kaninchen
61
15
4
Klonalität
Polyklonal
Konjugat
Dieser HIC2 Antikörper ist konjugiert mit Cy5
5
4
4
3
3
3
2
2
2
2
2
1
1
1
1
1
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
62
33
12
5
3
Optionen
Immunogen KLH conjugated synthetic peptide derived from human HIC2
Isotyp IgG
Reinigung Purified by Protein A.
Plasmids, Primers & others Plasmide, Primers & weitere HIC2 products on genomics-online (e.g. as negative or positive controls)
Antigen
Andere Bezeichnung Hic2 (HIC2 Antibody Abstract)
Hintergrund

Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a KrA1/4ppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. HIC-2 (hypermethylated in cancer 2) possesses zinc finger motifs that are thought to be important for DNA-binding and also has a BTB/POZ domain at the N-terminus, which is thought to be important for protein-protein binding, as well as for the binding of transcription factors. HIC-2 is also known as Hic-3, HIC1-related gene on chromosome 22 or Zinc finger and BTB domain-containing protein 30, and is a 615 amino acid protein that is expressed as two isoforms produced by alternative splicing. HIC-2 is highly expressed in cerebellum and is localized to the nucleus in cells. HIC-2 contains a short amino acid sequence that is thought to interact with CtBP, a transcriptional repressor. The gene sequence associated with HIC-2 is thought to be a target for miRNAs (microRNAs) which are expressed in many cancers, suggesting that HIC-2 could possess tumor suppressor capabilities.

Synonyms: HIC1 related gene on chromosome 22, HIC2, Hic3, HRG22, Hypermethylated in cancer 2 protein, KIAA1020, ZBTB30, Zinc finger and BTB domain-containing protein 30, ZNF907, HIC2_HUMAN.

Gen-ID 23119
Applikations-hinweise IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung Store at 4°C
Haltbarkeit 12 months
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