N-Acylsphingosine Amidohydrolase (Acid Ceramidase) 1 (ASAH1) Antikörper (Cy5)

Details zu Produkt Nr. ABIN1704226
Antigen
  • AC
  • ACDase
  • ASAH
  • PHP
  • PHP32
  • SMAPME
  • 2310081N20Rik
  • Asah
  • MGC82286
  • asah1
  • zgc:101637
  • ASAH1
  • N-acylsphingosine amidohydrolase 1
  • N-acylsphingosine amidohydrolase (acid ceramidase) 1
  • N-acylsphingosine amidohydrolase (acid ceramidase) 1 L homeolog
  • N-acylsphingosine amidohydrolase (acid ceramidase) 1a
  • Acid ceramidase
  • ASAH1
  • Asah1
  • asah1.L
  • asah1a
  • asah-1
Reaktivität
Human, Maus, Ratte (Rattus)
88
37
35
3
3
3
3
1
1
1
1
1
Wirt
Kaninchen
77
12
Klonalität
Polyklonal
Konjugat
Cy5
4
3
3
3
3
3
2
2
2
1
1
1
1
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
59
35
32
15
12
4
3
3
2
1
1
Optionen
Immunogen KLH conjugated synthetic peptide derived from human Acid ceramidase subunit beta
Isotyp IgG
Reinigung Purified by Protein A.
Antigen
Andere Bezeichnung Asah1 (ASAH1 Antibody Abstract)
Hintergrund

Acid ceramidase catalyzes the degradation of ceramide in normal tissues, and deficiency leads to accumulation of ceramide in tissues, a hallmark of Farber disease. Effected individuals experience early onset joint problems and neurological problems, owing to mutations in the acid ceramidase gene. Bioinformatic analysis of gene expression also reveals acid ceramidase to be among the 5 most important genes associated with melanoma. In addition to ceramide hydrolysis, purified acid ceramidase also exhibits the ability to catalyze ceramide synthesis, utilizing [14C]lauric acid and sphingosine as substrates. Interestingly, pH regulates which reaction is favored, for hydrolysis the pH optimum is 4.5, whereas for the reverse reaction favors a pH of 5.5, further supporting a complex and central role for acid ceramidase in sphingolipid metabolism.

Synonyms: AC, ACDase, Acid CDase, Acid ceramidase, Acid ceramidase precursor, Acid ceramidase subunit beta, Acylsphingosine deacylase, ASAH 1, ASAH, ASAH1, ASAH1_HUMAN, FLJ21558, FLJ22079, N acylsphingosine amidohydrolase acid ceramidase 1, N acylsphingosine amidohydrolase 1, N acylsphingosine amidohydrolase, N-acylsphingosine amidohydrolase, PHP, PHP32, Putative 32 kDa heart protein.

Gen-ID 427
Applikations-hinweise IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung Store at 4°C
Haltbarkeit 12 months
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