Cytohesin 2 Antikörper (CYTH2) (Cy5)

Details for Product anti-CYTH2 Antibody No. ABIN1704209
Antigen
  • ARNO
  • CTS18
  • CTS18.1
  • PSCD2
  • PSCD2L
  • SEC7L
  • Sec7p-L
  • Sec7p-like
  • CLM2
  • Pscd2
  • Arno
  • Sec7
  • Sec7B
  • pscd2
  • MGC84366
  • CYTH2
  • cyth2
  • cytohesin 2
  • cytohesin-2
  • cytohesin 2 L homeolog
  • si:dkey-283b15.4
  • CYTH2
  • PTRG_08834
  • Cyth2
  • cyth2.L
  • cyth2
  • si:dkey-283b15.4
Reaktivität
Human, Maus, Ratte (Rattus)
60
45
33
5
3
3
2
2
2
2
1
1
Wirt
Kaninchen
55
17
5
Klonalität
Polyklonal
Konjugat
Dieser Cytohesin 2 Antikörper ist konjugiert mit Cy5
4
4
4
3
3
3
1
1
1
1
1
1
1
1
1
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
65
40
13
12
10
7
5
3
2
1
Optionen
Immunogen KLH conjugated synthetic peptide derived from human Cytohesin 2
Isotyp IgG
Reinigung Purified by Protein A.
Plasmids, Primers & others Plasmide, Primers & weitere Cytohesin 2 products on genomics-online (e.g. as negative or positive controls)
Antigen
Andere Bezeichnung Cytohesin 2 (CYTH2 Antibody Abstract)
Hintergrund

The ADP-ribosylation factor (Arf) family comprises a group of structurally and functionally conserved 21 kDa proteins, which are members of the Ras superfamily of regulatory GTP-binding proteins. Arf is involved in intracellular protein traffic to and within the Golgi complex. Arf has a number of disparate activities including maintenance of organelle integrity, assembly of coat proteins, as a co-factor for cholera toxin and as an activator of phospholipase D. Like other small GTPases, Arf is found to be active when bound to GTP and inactive when bound to GDP. Arf’s activation is dependent upon guanine nucleotide exchange factors (GEFs) which increase the rate of exchange of bound GDP with GTP. All GEFs have a highly conserved Sec7 domain. GEF activity lies in the Sec7 domain and this activity has been shown to be inhibited by the fungal metabolite brefeldin-A (BFA). A small group of GEFs which are insensitive to brefeldin-A (BFA) include cytohesin-1 (B2-1), cytohesin-2 (ARNO), cytohesin-3 (ARNO3), and cytohesin-4. All cytohesins function in the cell periphery and contain a pleckstrin homology (PH) domain. The PH domain has been shown to interact with phosphatidylinositol 3,4,5-triphosphate and is believed to promote membrane targeting of the cytohesins. Recruitment of the cytohesins to the membranes can occur in response to tyrosine kinase receptor activation. This response appears to require the activation of phosphatidylinositol 3-kinase (PI 3-kinase).

Synonyms: ARF exchange factor, ARF nucleotide binding site opener, Arno, ARNO protein, CLM2, CTS18, CTS18.1, Cyth2, Cytohesin 2, MGC137537, MGC80440, PH, SEC7 and coiled-coil domain-containing protein 2, Pleckstrin homology Sec7 and coiled coil domains 2, Pleckstrin homology Sec7 and coiled coil domains protein 2, PSCD2, PSCD2L, PSCD2L, formerly, Sec7, SEC7 homolog B, Sec7B, SEC7L, Sec7p L, Sec7p-like, Sec7pL, CYH2_HUMAN.

Gen-ID 9266
Applikations-hinweise IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung Store at 4°C
Haltbarkeit 12 months
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