HTRA2 Antikörper (Ser306Ala-Mutant)

Produktnummer ABIN165414

Produktdetails anti-HTRA2 Antikörper

Target: HTRA2 (HtrA Serine Peptidase 2 (HTRA2))

Bindungsspezifität: Ser306Ala-Mutant

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser HTRA2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Aufreinigung: The antibody was purified from mouse ascitic fluids by protein-G affinity chromatography

Immunogen: Recombinant human HtrA2/Omi (134-458aa) purified from E. coli

Klon: 1B3

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Recommended dilution 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: In Phosphate-Buffered Saline (pH7.4) with 0.1% Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Can be stored at +2°C to +8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C. Avoid repeated freezing and thawing cycles.

Details zu HTRA2

Target: HTRA2 (HtrA Serine Peptidase 2 (HTRA2))

Andere Bezeichnung: HTRA2/OMI (HTRA2 Produkte)

Hintergrund: HtrA2/Omi is a mammalian serine protease at high temperatures and a chaperone at low temperature. The full-length HtrA2 is synthesized as a precursor protein and then targeted to the mitochondria where it is matured by the removal of N-terminal 133 residues. Mature HtrA2 consists of a putative transmembrane domain, an inhibitor of apoptosis protein (IAP) -binding motif, a single C-terminal PDZ domain that mediates protein-protein interactions. Recently, HtrA2 has known to contribute both to caspase-dependent and caspase-independent cell death.

NCBI Accession: NP_037379

Pathways: Positive Regulation of Endopeptidase Activity