Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

CNG Channel beta 1/truncated GARP Antikörper (PE)

Dieses Anti--Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von in . Geeignet für Human, Maus und Ratte.
Produktnummer ABIN1425960

Kurzübersicht für CNG Channel beta 1/truncated GARP Antikörper (PE) (ABIN1425960)

Target

CNG Channel beta 1/truncated GARP

Reaktivität

Human, Maus, Ratte

Wirt

  • 15
Kaninchen

Klonalität

  • 15
Polyklonal

Konjugat

  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
PE

Applikation

Bitte anfragen
  • Aufreinigung

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from human truncated GARP

    Isotyp

    IgG
  • Kommentare

    Exitation/Emission: 480,565nm/578nm

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 μg/μL

    Buffer

    Aqueous buffered solution containing 100 μg/mL BSA, 50 % glycerol and 0.09 % sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at 4°C

    Haltbarkeit

    12 months
  • Target

    CNG Channel beta 1/truncated GARP

    Hintergrund

    Glutamic acid rich protein (GARP) is a soluble protein localized to the outer segments of the rod photoreceptor. It forms a subunit of cyclic nucleotide-gated (CNG) channels, nonselective cation channels, which play important roles in both visual and olfactory signal transduction. When associated with CNGA1, it is involved in the regulation of ion flow into the rod photoreceptor outer segment (ROS), in response to light-induced alteration of the levels of intracellular cGMP. There are 3 isoforms produced by alternative splicing. Isoform GARP2 is a high affinity rod photoreceptor phosphodiesterase (PDE6)-binding protein that modulates its catalytic properties, it is a regulator of spontaneous activation of rod PDE6, thereby serving to lower rod photoreceptor 'dark noise' and allowing these sensory cells to operate at the single photon detection limit. Defects in GARP are the cause of retinitis pigmentosa type 25 (RP25). RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.

    Subcellular location: Extracellular


    Synonyms: CNCG 4, CNCG2, CNCG3L, CNCG4, CNG 4, CNG channel 4, CNG channel beta 1, CNG4, CNGB 1, CNGB1, CNGB1B, Cyclic nucleotide gated cation channel 4, Cyclic nucleotide gated cation channel, Cyclic nucleotide gated cation channel beta 1, Cyclic nucleotide gated cation channel gamma, Cyclic nucleotide gated cation channel modulatory subunit, Cyclic nucleotide gated channel photoreceptor cGMP gated 3 gamma like, Cyclic nucleotide gated channel beta 1, GAR1, GARP, GARP2, Glutamic acid rich protein, RCNC2, RCNCb, RCNCbeta, RP45, 240 kDa protein of rod photoreceptor CNG channel, cGMP gated cation channel beta subunit, Truncated glutamic acid rich protein, Truncated rod photoreceptor cGMP gated channel beta subunit, Truncated rod photoreceptor cGMP-gated channel beta-subunit, CNGB1_HUMAN.
Sie sind hier:
Chat with us!