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S100 Protein (S100) Antikörper Primary Antibody

S100 Reaktivität: Rind (Kuh) ELISA, WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN129527
$744.00
Zzgl. Versandkosten $45.00
500 μg
local_shipping Lieferung nach: Vereinigte Staaten von Amerika
Lieferung in 1 bis 2 Werktagen
  • Target Alle S100 Protein (S100) Antikörper anzeigen
    S100 Protein (S100)
    Reaktivität
    • 36
    • 12
    • 11
    • 9
    • 1
    • 1
    Rind (Kuh)
    Wirt
    • 25
    • 24
    • 1
    Kaninchen
    Klonalität
    • 26
    • 24
    Polyklonal
    Konjugat
    • 24
    • 10
    • 5
    • 3
    • 3
    • 2
    • 2
    • 1
    Unkonjugiert
    Applikation
    • 34
    • 29
    • 19
    • 12
    • 7
    • 7
    • 7
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    ELISA, Western Blotting (WB)
    Produktmerkmale
    Concentration Definition: by UV absorbance at 280 nm
    Immunogen
    This Protein A purified antibody was prepared from whole rabbit serum produced by repeated immunizations with full-length bovine S100 protein (mixture of aa homodimers and ab heterodimers).
    Immunogentype:Native
    Isotyp
    IgG
  • Applikationshinweise
    This Protein A purified antibody has been tested for use in ELISA and western blot.  Specific conditions for reactivity should be optimized by the end user. Expect a band ~ 11 kDa in size corresponding to S100 monomer by western blotting in the appropriate cell lysate or extract.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Restore with deionized water (or equivalent)
    Konzentration
    5.0 mg/mL
    Buffer
    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
  • Target
    S100 Protein (S100)
    Andere Bezeichnung
    S100 Protein (S100 Produkte)
    Synonyme
    S100, S100-alpha, S100A, NEF, S100-B, S100beta, S100A1, AI266795, S100a, S100 calcium binding protein A1, S100 calcium binding protein B, S100 calcium binding protein A13, S100A1, S100B, S100a1, S100a13
    Hintergrund
    S-100 protein derived from brain tissue is an acidic calcium-binding protein with molecular weight of about 21kDa. In human brain tissue S-100 protein is mainly presented as two isoforms - bb homodimer (S-100b) and ab heterodimer (S-100a). Because of its predominant location in astroglial cells S-100 protein can be used as a sensitive and reliable marker for central nervous system injury. Structural damage of glial cells causes leakage of S-100 protein into the extracellular matrix and into cerebrospinal fluid, further releasing into the bloodstream. Measurements of S-100 protein in patient serum samples are useful in monitoring of traumatic brain injury, ischemic brain damage after circulatory arrests, and in diagnosis and prognosis of clinical outcome in acute stroke.  Although predominant among the water-soluble brain proteins, S-100 is also found in a variety of other tissues. S-100 is an intracellular protein that weakly binds calcium. It binds zinc very tightly, however, and this appears to increase the affinity of the protein for calcium. Distinct binding sites, with different affinities, exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites.
    Synonyms: S100 calcium-binding protein A1 S-100 protein subunit alpha S-100 protein alpha chain
    Gen-ID
    6271, 30582715
    UniProt
    P02639
    Pathways
    Regulation of Muscle Cell Differentiation, Toll-Like Receptors Cascades, S100 Proteine
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