PLP1 Antikörper (C-Term)

Produktnummer ABIN119026

Produktdetails anti-PLP1 Antikörper

Target: PLP1 (Proteolipid Protein 1 (PLP1))

Bindungsspezifität: C-Term

Reaktivität: Human, Rind (Kuh), Säugetier

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser PLP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Spezifität: This antibody recognizes Myelin Proteolipid protein (PLP) in many Mammalian species. This antibody also recognizes DM20.

Kreuzreaktivität (Details): Species reactivity (tested):Bovine.

Aufreinigung: Affinity Chromatography on Protein A from Tissue Culture Supernatant

Immunogen: Synthetic peptide CGRGTKF corresponding to C-terminal region of Myelin Proteolipid Protein. Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP2/0 myeloma cell line.

Klon: Plpc1

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Western blot. Immunohistochemistry on Frozen Sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS, 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu PLP1

Target: PLP1 (Proteolipid Protein 1 (PLP1))

Andere Bezeichnung: PLP1 (PLP1 Produkte)

Hintergrund: Myelin proteins are associated with the central nervous system (CNS) and play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. The proteolipid protein (PLP) and its splice variant DM20 are the predominant myelin proteins in the CNS. PLP is also one of the most extensively studied myelin proteins because of the prevelance of PLP mutations amongst humans and animals. Such mutations can lead to abnormal myelin formation resulting in conditions such as X-linked Pelizaeus-Merzbacher disease and spastic paraplegia type 2. PLP encodes the major protein components of compact CNS myelin and mutations in the PLP gene can lead to severe dysmyelinating disease.Synonyms: Lipophilin, Myelin proteolipid protein, PLP

Gen-ID: 281410

NCBI Accession: NP_776574

UniProt: P04116