RECK
Reaktivität: Human
ELISA, IHC, IF
Wirt: Kaninchen
Polyclonal
unconjugated
Applikationshinweise
Optimal working dilution should be determined by the investigator.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Konzentration
1.0 mg/mL
Buffer
PBS containing 50 % glycerol, pH 7.2. No preservative is contained.
Konservierungsmittel
Without preservative
Handhabung
Avoid repeated freezing and thawing.
Lagerung
-20 °C
Informationen zur Lagerung
Store (in aliquots) at -20 °C.
Target
RECK
(Reversion-Inducing-Cysteine-Rich Protein with Kazal Motifs (RECK))
Andere Bezeichnung
RECK / ST15
Hintergrund
A membrane-anchored glycoprotein, RECK is encoded by a RECK gene (reversion-inducing cysteine-rich protein with Kazal motifs) identified as a transformation suppressor gene. This 110 kDa protein consists of 971a.a. The protein contains protease inhibitor like domains such as the Kazal motif, and epidermal growth factor (EGF) like repeats. Takahashi et al. reported that restoration pf RECK expression in malignant cells resulted in suppression of invasive activity with a concomitant decrease in the secretion of matrix metalloproteinase-9 (MMP-9), a key enzyme involved in tumor invasion and metastasis.Synonyms: Reversion-inducing cysteine-rich protein with Kazal motifs, Suppressor of tumorigenicity 15 protein