ACR-Modified Keyhole-Lympet Hemocyanine Antikörper

Produktnummer ABIN1020376

Dieses Maus Monoklonal-Antikörper erkennt spezifisch in IHC. Er zeigt eine Reaktivität gegenüber und wurde in 1 Publikation erwähnt.

Kurzübersicht für ACR-Modified Keyhole-Lympet Hemocyanine Antikörper (ABIN1020376)

Target: ACR-Modified Keyhole-Lympet Hemocyanine

Wirt: Maus

Klonalität: Monoklonal

Applikation: Immunohistochemistry (IHC)

Klon: 5F6

Produktdetails

Spezifität: Specific for ACR-modified protein (especially FDP-lysine type derivative).

Aufreinigung: Protein A purified

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Recommended antibody concentration is 0.5-1.0 µg/mL on paraformaldehyde fixed tissue.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Frozen

Buffer: 100 µg/mL antibody in 10mM PBS containing 0.1% NaN3 and 0.5% BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Referenzen

Sugiyama, Sun, Nishinohara, Fujita, Masuda, Ochi, Takeuchi: "Expressions of lipid oxidation markers, N(ε)-hexanoyl lysine and acrolein in cisplatin-induced nephrotoxicity in rats." in: The Journal of veterinary medical science / the Japanese Society of Veterinary Science, Vol. 73, Issue 6, pp. 821-6, (2011) (PubMed).

Antigendetails

Target: ACR-Modified Keyhole-Lympet Hemocyanine

Hintergrund: Acrolein (ACR) is a representative carcinogenic aldehyde found ubiquitously in the environment and formed endogenously through oxidation reactions, such as lipid peroxidation and myeloperoxidasecatalyzed amino acid oxidation. ACR is highly reactive aldehyde and reacts with lysine residue in protein. The reaction with ACR and lysine residue leads to the formation of numerous numbers of adducts, such as formyl-dehydropiperidino-lysine (FDP-lysine) type derivative. This antibody is specific for the ACR-modified protein, especially FDP-lysine type derivative.