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These results suggest that berberine-induced activation of AMPK may contribute to hepatic FGF21 (zeige FGF21 Proteine) expression via NUR77 (zeige NR4A1 Proteine).
AMPK enhances intestinal barrier function and epithelial differentiation via promoting CDX2 (zeige CDX2 Proteine) expression, which is partially mediated by altered histone modifications in the Cdx2 (zeige CDX2 Proteine) promoter.
activation of AMPK upregulated Smad6 (zeige SMAD6 Proteine) and Smurf1 (zeige SMURF1 Proteine) and thereby enhanced their interactions, resulting in its proteosome-dependent degradation of ALK2 (zeige ACRV1 Proteine).
Lack of mitochondrial DNA impairs chemical hypoxia-induced autophagy in liver tumor cells through reactive oxygen species-AMPK-ULK1 (zeige ULK1 Proteine) signaling dysregulation independently of HIF-1A (zeige HIF1A Proteine).
Data indicate that nesfatin-1/NUCB-2 (zeige NUCB2 Proteine) enhanced migration, invasion and epithelial-mesenchymal transition (EMT (zeige ITK Proteine)) in colon cancer cells through LKB1 (zeige STK11 Proteine)/AMPK/TORC1 (zeige CRTC1 Proteine)/ZEB1 pathways in vitro and in vivo.
Taken together, these results demonstrate that piperine enhance osteoblast differentiation through AMPK phosphorylation in MC3T3-E1 cells.
AMP-activated protein kinase (AMPK (zeige PRKAA2 Proteine)) regulates autophagy by phosphorylating BECN1 (zeige BECN1 Proteine) at Thr388
activation of AMPK might be a stress response of host cells to restrict virus production through promotion of autophagic degradation
The results suggest that SESN2 (zeige SESN2 Proteine) increases degradation of HIF-1A (zeige HIF1A Proteine) via AMPK-PHD (zeige PDC Proteine) regulation that contributes to inhibition of in vitro and in vivo tumorigenesis.
These results demonstrate that Poly(ADP-ribosyl)ation of AMPK is a key early signal to efficiently convey extracellular nutrient perturbations with downstream events needed for the cell to optimize autophagic commitment before autophagosome formation.
Endometrial inflammatory responses to lipopolysaccharide were also reduced by small molecules that activate or inhibit the intracellular sensor of energy, AMP-activated protein kinase (AMPK (zeige PRKAA2 Proteine)).
The results suggest that activation of AMPK represses global protein synthesis in mammary epithelial cells through inhibition of mTORC1 signaling.
Nitrated oleic acid activates AMPK in endothelial cells.
Findings suggest that ischemic factor stimulation of the blood brain barrier Na-K-Cl cotransporter (zeige SLC12A1 Proteine) involves activation of AMPK.
Results suggest that mitochondria-derived superoxide anions and peroxynitrite are required for Berberine-induced AMPK activation in endothelial cells.
the expression, but not the kinase activity, of AMPK and CaMKKbeta is necessary for ADP signaling to eNOS (zeige NOS3 Proteine)
AMPK-related pathways may be compromised during fluoxetine exposure as a result of increased miRNA abundance.
Klotho (zeige KL Proteine) gene deficiency promotes high-fat diet-induced fibrosis in aortic valves, likely through the AMPKalpha (zeige GRK4 Proteine)-RUNX2 (zeige RUNX2 Proteine) pathway.
AMPK-mTOR (zeige FRAP1 Proteine)-autophagy signaling is altered by intrauterine growth restriction in newborn piglets.
Data indicate that 17beta-estradiol reduced Sertoli Cell proliferation by inhibiting microRNA miR (zeige MYLIP Proteine)-1285 and thus activating AMP-activated protein kinase (AMPK (zeige PRKAA2 Proteine)).
L-Glutamine enhances enterocyte growth but did not affect abundances of total or phosphorylated AMPK protein.
AMPK activity plays an important role in the maintenance of the spermatozoa quality during long-term storage of boar semen.
AMPK, lying downstream of PKA, regulates at different levels mammalian spermatozoa membrane function.
Porcine circovirus type 2 (PCV2) might induce autophagy via the AMPK/ERK (zeige MAPK1 Proteine)/TSC2/mTOR (zeige FRAP1 Proteine) signaling pathway in the host cells, representing a pivotal mechanism for PCV2 pathogenesis
AMPK deficiency or inhibition attenuated or mitigated ethanol exposure-triggered glucose intolerance and compromised cardiac contraction by increased phosphorylation of AMPK and acetyl-CoA carboxylase as well as autophagosome accumulation.
AMPK functions to inhibit IGF-I (zeige IGF1 Proteine)-stimulated PI3K pathway activation through stimulation of IRS-1 (zeige IRS1 Proteine) serine 794 phosphorylation.
acute activation of AMPK increases intestinal glucose absorption after administration of long-chain n-3 polyunsaturated fatty acids during gestation
our results elucidate a previously unrecognized role of AMPKalpha1 deletion in loss of contact inhibition of cellular proliferation and angiogenesis
AMPK and Sirt2 (zeige SIRT2 Proteine) control compensatory glucose uptake in metabolically arrested mitochondria.
AMPK regulates T cell survival and function. Demonstrate AMPK-dependent and independent rolesof AICAR (zeige ATIC Proteine)/Compound C in regulating T cell responses.
AMPK was sufficient to stimulate osteogenesis of MC3T3-E1 cells and inhibit adipogenesis of 3T3-L1 cells through the AMPK-Gfi1 (zeige ZNF163 Proteine)-OPN (zeige SPP1 Proteine) axis.
PRKAA (zeige PRKAA2 Proteine) deletion promoted mitochondrial fragmentation in vascular endothelial cells by inhibiting the autophagy-dependent degradation of DNM1L (zeige DNM1L Proteine).
AMPK activation reduces the formation of atheromata-inducing macrophages in ApoE(-/-)-deficient mice by inhibiting expression of Ccr2, thereby preventing the Ccr2-mediated migration of Ly6C(hi) monocytes from the bone marrow.
Thus we concluded that the AMPKalpha (zeige GRK4 Proteine)-SIRT1 (zeige SIRT1 Proteine) molecular pathway may be a molecular mechanism of IR in PCOS and may serve as a therapeutic target for the development of potential treatments for improving metabolic and reproductive function in PCOS.
Constitutively active AMPKgammaR70Q significantly decreases Napi-IIa oocyte cell membrane abundance, an effect not mimicked by catalytically-inactive AMPKalphaK45R.
NDPK-A (zeige NME1 Proteine) exists in a functional cellular complex with AMPK (zeige PRKAA2 Proteine) and CFTR (zeige CFTR Proteine) in airway epithelia, and NDPK-A (zeige NME1 Proteine) catalytic function is required for the AMPK (zeige PRKAA2 Proteine)-dependent regulation of CFTR (zeige CFTR Proteine)
The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
5'-AMP-activated protein kinase catalytic subunit alpha-1
, 5'-AMP-activated protein kinase, catalytic alpha-1 chain
, ACACA kinase
, AMP -activate kinase alpha 1 subunit
, AMP-activated protein kinase, catalytic, alpha-1
, AMPK alpha 1
, AMPK subunit alpha-1
, HMGCR kinase
, acetyl-CoA carboxylase kinase
, hydroxymethylglutaryl-CoA reductase kinase
, tau-protein kinase PRKAA1
, 5'-AMP-activated protein kinase alpha-1 catalytic subunit
, 5'-AMP-activated protein kinase alpha 1 catalytic subunit
, 63 kDa subunit
, AMPK 63 kDa subunit
, AMPK alpha-1 chain
, AMP-activated protein kinase, alpha 1 catalytic subunit
, 5'-AMP-activated protein kinase catalyti subunit alpha-1-like protein
, AMPK-activated protein kinase alpha-1 subunit
, protein kinase, AMP-activated, alpha 1 catalytic subunit