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AML patients with high SIN3 A expression levels had a worse prognosis than those with low expression. The same Y325Cvariant seen in endometrial carcinoma was found in one AML patient. It was calculated to cause a predicted stability change of -1.433 Kcal/mol, indicating significant disruption of the secondary structure.
High mRNA expression of SIN3A/low mRNA expression of SIN3B correlates with longer relapse free survival specifically in patients with triple negative breast cancer.
THO interacts with the Sin3A histone deacetylase complex to suppress co-transcriptional R-loops, DNA damage, and replication impairment. Functional analyses show that histone hypo-acetylation prevents accumulation of harmful R-loops and RNA-mediated genomic instability.
the FOXN3-NEAT1-SIN3A complex promotes epithelial-to-mesenchymal transition and invasion of breast cancer cells in vitro as well as dissemination and metastasis of breast cancer in vivo
Haploinsufficiency of SIN3A causes mild intellectual disability by affecting the development of cortical integrity.
Two novel translocations leading to the inactivation of RUNX1 and its partners SIN3A and TCF12 in myeloid leukemia.
Study suggests a lack of association of SIN3A gene sequence variants with azoospermia caused by Sertoli cell-only syndrome in humans.
down regulation of miR-202 increased the expression of its target Mxd1, followed by Mxd1 recruitment to the Sin3A repressor complex and through its dimerization with Max, and increased repression of Myc-Max target proteins.
protein pairs significantly correlated with an increased risk of death in non-small cell lung cancer: mSin3A with p16, and c-Myc with mSinA
Aberrantly expressed miR-210 regulates human U251 glioma cells apoptosis and proliferation partly through directly down-regulating SIN3A protein expression.
Bone-marrow-specific deletion of Sin3a, indicated that Sin3a-associated HDAC1/2-activity is essential for hematopoietic stem cell homeostasis.
SIN3A, generally regarded as a transcriptional repressor, is required for induction of gene transcription by the aryl hydrocarbon receptor.
EBNA3C binds strongly to BATF/IRF4/SPI1/RUNX3 sites to enhance transcription and recruits RBPJ/Sin3A- and REST/NRSF-repressive complexes to repress p14(ARF) and p16(INK4A) expression
BIM silencing in anaplastic large cell lymphoma occurs through recruitment of MeCP2 and the SIN3a/histone deacetylase 1/2 corepressor complex.
reducing Sin3A strongly increased the invasive behavior of A549 human lung adenocarcinoma cells; findings show that Sin3A is downregulated in a variety of human tumors
The Sin3a complex acts as a context-dependent ISGF3/STAT3 transcriptional switch.
Ume6 is a negative regulator of ATG8 transcription, which acts along with a histone deacetylase complex including Sin3 and Rpd3 to regulate Atg8 levels
Interplay between SIN3A and STAT3 mediates chromatin conformational changes and GFAP expression during cellular differentiation.(
Sin3a, HDAC1, and YY1 are co-factors for Gon4l and that Gon4l may function as a platform for the assembly of complexes that regulate gene expression.
The study identifies Sin3A as a regulator of gene expression, survival, and growth in ERalpha-positive breast cancer cells.
The protein encoded by this gene is a transcriptional regulatory protein. It contains paired amphipathic helix (PAH) domains, which are important for protein-protein interactions and may mediate repression by the Mad-Max complex.
SIN3 homolog A, transcription regulator
, SIN3 transcription regulator homolog A
, histone deacetylase complex subunit Sin3a
, paired amphipathic helix protein Sin3a
, transcriptional co-repressor Sin3A
, transcriptional corepressor Sin3a
, transcriptional regulator, SIN3A
, transcriptional regulator, SIN3 yeast homolog A
, SIN3 homolog A, transcription regulator (yeast)
, paired amphipathic helix protein Sin3a-like
, SIN3 homolog A, transcription regulator a