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Petrey, Flanagan-Steet, Johnson, Fan, De la Rosa, Haskins, Nairn, Moremen, Steet: Excessive activity of cathepsin K is associated with cartilage defects in a zebrafish model of mucolipidosis II. in Disease models & mechanisms 2012
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McComb, Shutinoski, Thurston, Cessford, Kumar, Sad: Cathepsins limit macrophage necroptosis through cleavage of Rip1 kinase. in Journal of immunology (Baltimore, Md. : 1950) 2014
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Human Cathepsin S ELISA Kit für Sandwich ELISA - ABIN415099
Gu, Lü, Chen, Zhou, Song, Jin, Liu: Relationship between plasma cathepsin S and cystatin C levels and coronary plaque morphology of mild to moderate lesions: an in vivo study using intravascular ultrasound. in Chinese medical journal 2010
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Mouse (Murine) Cathepsin S ELISA Kit für Sandwich ELISA - ABIN415776
Steubl, Kumar, Tato, Mulay, Larsson, Lind, Risérus, Renders, Heemann, Carlsson, Ärnlöv, Anders: Circulating cathepsin-S levels correlate with GFR decline and sTNFR1 and sTNFR2 levels in mice and humans. in Scientific reports 2017
Overall, these results indicate that exploitation of the cathepsin S activity in MPS tissues can be utilized to substantially lower non-target accumulation, suggesting this is a promising approach for the development of diagnostic and radiotherapeutic nanomedicine platforms.
polymorphism of rs7534124 and rs1136774 in cathepsin S promoter may decrease the susceptibility of asthma in a Chinese Han population
cathepsin S mRNA (CTSS), which encodes a cysteine protease (zeige CTSB ELISA Kits) associated with angiogenesis and atherosclerosis, is highly edited in human endothelial cells. RNA editing enables the recruitment of the stabilizing RNA-binding protein (zeige PTBP1 ELISA Kits) human antigen R (HuR (zeige ELAVL1 ELISA Kits); encoded by ELAVL1 (zeige ELAVL1 ELISA Kits)) to the 3' UTR (zeige UTS2R ELISA Kits) of the CTSS transcript, thereby controlling CTSS mRNA stability and expression.
levels of cathepsin S and hsCRP observed in women who later developed breast cancer may provide prognostic information regarding tumor development and need to be evaluated in prospective studies.
p41 (zeige EPB41 ELISA Kits) fragment is also shown to reduce the secretion of interleukin-12 (IL-12 (zeige IL12A ELISA Kits)/p70 (zeige ANXA6 ELISA Kits)) during the subsequent maturation of treated dendritic cells.
shedding of surface proteins by extracellular cathepsins impacts intracellular signaling as demonstrated for regulation of Ras GTPase (zeige RACGAP1 ELISA Kits) activity.
the essential role of autophagy-regulated early ROS (zeige ROS1 ELISA Kits) in triggering late apoptotic signaling
Cathepsin S cleaves near the N-terminus of PAR2 (zeige F2RL1 ELISA Kits) to expose a novel tethered ligand, KVDGTS.
Increased plasma CTSS concentration is associated with atherogenesis.
results identify Cat-S as a biased agonist of PAR2 (zeige F2RL1 ELISA Kits) that causes PAR2 (zeige F2RL1 ELISA Kits)- and TRPV4 (zeige TRPV4 ELISA Kits)-dependent inflammation and pain.
the roles of CTSB (zeige CTSB ELISA Kits)/S and SIRT1 (zeige SIRT1 ELISA Kits) in the regulation of hepatic inflammation using primary parenchymal and non-parenchymal hepatic cell types and cell lines.
Cathepsin S activity controls injury-related vascular remodeling via TLR2 (zeige TLR2 ELISA Kits)/p38MAPK (zeige MAPK14 ELISA Kits)/PI3K/Akt (zeige AKT1 ELISA Kits)/p-HDAC6 (zeige HDAC6 ELISA Kits) signaling pathway.
Loss of Rab3D (zeige RAB3D ELISA Kits) from secretory vesicles, leading to disproportionate Rab27 (zeige RAB27A ELISA Kits)-to-Rab3D (zeige RAB3D ELISA Kits) activity, may contribute to the enhanced release of cathepsin S in tears of patients with Sjogren's syndrome.
Ctss induction during muscular dystrophy is a pathologic event that partially underlies disease pathogenesis, and its inhibition might serve as a new therapeutic strategy in Duchenne muscular dystrophy (zeige DMD ELISA Kits).
Demonstrate the utility of intracellular caspase 1 (zeige CASP1 ELISA Kits) and extracellular CTSS proteolytic activities as surrogate biomarkers of lysosomal rupture and acute inflammation.
Fluorogen substrate, Mca-GRWPPMGLPWE-Lys (zeige LYZ ELISA Kits)(Dnp)-DArg-NH2 can detect CTSS activities in mouse antigen presenting cells.
Data show that cathepsins S (CatS) regulates CCL2 (zeige CCL2 ELISA Kits) chemokine (zeige CCL1 ELISA Kits) expression by modulation of CD74 (zeige CD74 ELISA Kits) antigen processing.
Cathepsin S activates MrgprC11 (zeige MRGPRX1 ELISA Kits) and evokes receptor-dependent scratching in mice.
cathepsin S deficiency alters the balance between adipocyte and osteoblast differentiation, increases bone turnover, and changes bone microarchitecture. Therefore, bone and fat metabolisms should be monitored when using cathepsin S inhibitors clinically
These results, together with those previously reported for other genes of this family, suggest that cathepsin genes play a role in defining economically important traits in pigs.
The cathepsin S deserves further evaluation as therapeutic targets to develop disease modifying drugs to treat Alzheimer's disease.
The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. The encoded protein can function as an elastase over a broad pH range in alveolar macrophages. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
, cathepsin S, gene 1
, Cathepsin S
, Cat S