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Here, we review the role and effects of ACE2 (zeige ACE2 ELISA Kits), ACE2 (zeige ACE2 ELISA Kits) activators, Ang-(1 (zeige ANGPT1 ELISA Kits)-7) and synthetic Mas receptor agonists in the control of inflammation and fibrosis in cardiovascular and renal diseases and as counter-regulators of the ACE (zeige ACE ELISA Kits)-Ang II (zeige AGT ELISA Kits)-AT1 (zeige AGTR1 ELISA Kits) axis.
Downregulation of ACE2 (zeige ACE2 ELISA Kits)/Ang-(1 (zeige ANGPT1 ELISA Kits)-7)/Mas axis stimulates breast cancer metastasis through the activation of store-operated calcium entry and PAK1 (zeige PAK1 ELISA Kits)/NF-kappaB (zeige NFKB1 ELISA Kits)/Snail1 (zeige SNAI1 ELISA Kits) pathways.
These results indicated that angiotensin-(1-7)/ACE2/Mas axis may reduce liver lipid accumulation partly by regulating lipid-metabolizing genes through ATP/P2 receptor/CaM signaling pathway.
Ang-(1 (zeige ANGPT1 ELISA Kits)-7) downregulated AT1R (zeige AGTR1 ELISA Kits) mRNA, upregulated mRNA levels of Ang II (zeige AGT ELISA Kits) type 2 receptor (AT2R (zeige AGTR2 ELISA Kits)) and Mas receptor (MasR) and p38-MAPK (zeige MAPK14 ELISA Kits) phosphorylation and suppressed H22 cell-endothelial cell communication
MAS1 might act as an inhibitory regulator of breast cancer.
Data show that MAS receptor exhibited constitutive activity that was inhibited by the non-peptide inverse agonist.
Data suggest that angiotensin converting enzyme 2 (zeige ACE2 ELISA Kits)/angiotensin II-(1-7)/MAS1 axis regulates leukocyte recruitment/activation, cell proliferation, and inflammation/fibrosis; main topic here is kidney/inflammatory renal disease. [REVIEW]
Up-regulation of the ACE2 (zeige ACE2 ELISA Kits)/Ang-(1 (zeige ANGPT1 ELISA Kits)-7)/Mas axis protected against pulmonary fibrosis by inhibiting the MAPK (zeige MAPK1 ELISA Kits)/NF-kappaB (zeige NFKB1 ELISA Kits) pathway.
A proximal promoter construct for the MAS gene was repressed by the SOX (zeige PIPOX ELISA Kits) [SRY (zeige SRY ELISA Kits) (sex-determining region on the Y chromosome) box] proteins SRY (zeige SRY ELISA Kits), SOX2 (zeige SOX2 ELISA Kits), SOX3 (zeige SOX3 ELISA Kits) and SOX14 (zeige SOX14 ELISA Kits), of which SRY (zeige SRY ELISA Kits) is known to interact with the KRAB domain.
Mas appears to be a critical component required for NO-mediated vasodilatation induced by renin angiotensin system-dependent and RAS-independent agonists and therefore arises as a key pharmacological target to modulate endothelial function
This study aimed to define whether sex chromosome complement (SCC (zeige CYP11A1 ELISA Kits)) may differentially modulate sex differences in relative gene expression of basal Agtr1a (zeige AGTR1 ELISA Kits), Agtr2 (zeige AGTR2 ELISA Kits), and Mas1 receptors at fore/hindbrain nuclei and at medulla/cortical kidney.
MasR deficiency abolishes protection of female mice from obesity-induced hypertension
Results suggest that angiotensin converting enzyme 2 (zeige ACE2 ELISA Kits) may reduce anxiety-like behavior by activating central Mas receptor that facilitate GABA release onto pyramidal neurons within the basolateral amygdala.
impairment of the ANG-(1 (zeige ANGPT1 ELISA Kits)-7)/Mas receptor pathway may lead to worsening of the pathophysiological changes of asthma.
The data indicate a significant function of Ang-(1 (zeige ANGPT1 ELISA Kits)-7) in the regulation of insulin (zeige INS ELISA Kits) secretion from mouse islets in vitro and in vivo, mainly, but not exclusively, by Mas-dependent signaling, modulating the accessory pathway of insulin (zeige INS ELISA Kits) secretion via increase in cAMP.
This study suggests that deletion of AT2R decreases the expression of the beneficial ACE2/Ang-(1-7)/MasR.
Ang-(1 (zeige ANGPT1 ELISA Kits)-7)/Mas axis seems more important in autonomic modulation of arterial pressure than heart rate.
Mas receptor mediates cardioprotection of angiotensin-(1-7) against Ang II (zeige AGT ELISA Kits)-induced cardiomyocyte autophagy and cardiac remodelling through inhibition of oxidative stress.
MAS receptors mediate vasoprotective and atheroprotective effects of candesartan upon the recovery of vascular ACE2 (zeige ACE2 ELISA Kits)-angiotensin-(1-7)-MAS axis functionality
Mas receptor deficiency results in exacerbated inflammation in LPS (zeige TLR4 ELISA Kits)-challenged mice, which suggest a potential role for the Mas receptor as a regulator of systemic and brain inflammatory response induced by LPS (zeige TLR4 ELISA Kits).
The objective of this study was to characterize the profiles of Ang-(1-7), MAS receptor, ACE(2), NEP and PEP during the ovulatory process in cattle.
oncogene\; may be involved in function or development of neural tissues
, MAS proto-oncogene
, angiotensin-(1-7) receptor
, MAS1 oncogene