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The protein encoded by SRSF3 is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Zusätzlich bieten wir Ihnen SRSF3 Antikörper (69) und SRSF3 Kits (8) und viele weitere Produktgruppen zu diesem Protein an.
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Human SRSF3 Protein expressed in Wheat germ - ABIN1319754
Walsh, Suchanek, Cyphert, Kohan, Szeszel-Fedorowicz, Salati: Serine arginine splicing factor 3 is involved in enhanced splicing of glucose-6-phosphate dehydrogenase RNA in response to nutrients and hormones in liver. in The Journal of biological chemistry 2013
Show all 2 Pubmed References
Findings reveal the molecular mechanism of SRSF3 in pri-miRNA processing and support the previously proposed explanation for the highly conserved position of CNNC in SRSF3-enhanced pri-miRNA processing.
High expression of SRSF3 is associated with oral squamous cell carcinoma.
RBM4 (zeige RBM4 Proteine)-SRSF3-MAP4K4 (zeige MAP4K4 Proteine) constitutes a novel mechanism for manipulating the metastasis of colorectal cancer cells through the JNK1 (zeige MAPK8 Proteine) signaling pathway.
MicroRNA-1908-5p contributes to the oncogenic function of the splicing factor (zeige SLU7 Proteine) SRSF3 via NKIRAS2 (zeige NKIRAS2 Proteine) axis in osteosarcoma cells.
Dehydroepiandrosterone (DHEA) and cortisol modulate SRSF9 (zeige SFRS9 Proteine) and SRSF3 in a different way and data suggest that the anti-glucocorticoid effect of DHEA, among other mechanisms, is also exerted by modulating the expression of proteins involved in the splicing of the GR pre-mRNA.
that SRSF3 controls the expression of the miR (zeige MLXIP Proteine)-132/212 cluster through regulating REST expression
Alternative splicing of U2AF1 (zeige U2AF1 Proteine) reveals a shared repression mechanism for duplicated exons controlled by SRF3.
Introduction of point mutations in the SRSF3-binding site or knockdown of SRSF3 expression in cells reduces human papillomavirus 18 929;3434 splicing and E1;E4 production but activates other, minor 929;3465 and 929;3506 splicing. Knockdown of SRSF3 expression also enhances the expression of E2 and L1 mRNAs.
data indicate that the Human Papillomavirus E2 protein (zeige UBE2B Proteine) links (zeige CCDC40 Proteine) the viral replication cycle to epithelial differentiation via SRSF3, a key cellular regulator of high-risk (HR)-HPV gene expression
Results suggested that SRSF3 is associated with the initiation and development of OSCC and may be a biomarker and therapeutic target of OSCC.
SRSF3 regulates the innate immune response in resident microglia.
Data liver/mammary gland expressing Srsf3 siRNA displayed a suppressed level of Srsf3 protein, but not the mRNA.
This study provides the first evidence for a SRSF3-driven genetic programme required for morphological and functional differentiation of hepatocytes that may have relevance for human liver disease and metabolic dysregulation.
Serine arginine splicing factor (zeige SLU7 Proteine) 3 is involved in enhanced splicing of glucose-6-phosphate dehydrogenase (zeige G6PD Proteine) RNA in response to nutrients and hormones in liver
SRSF3 and SRSF4 (zeige SRSF4 Proteine) proteins bind to the 3' ends of the majority of intronless histone transcripts, implicating SRSF3 and SRSF4 (zeige SRSF4 Proteine) in histone mRNA metabolism.
Results suggest that increased SRp20 expression in tumor cells is a critical step for tumor initiation, progression, and maintenance.
mRNA targets of SRp20 and SRp75 were identified in cycling and neurally induced P19 cells.
Hippocampal mRNA expression of Srp20 is up-regulated only in males during contextual fear memory formation as a specific result of the context/tone-shock association. Changes in expression during LTM formation regulate alternative splicing.
The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants, one protein-coding and the other non-coding, have been found for this gene.
pre-mRNA-splicing factor SRP20
, splicing factor, arginine/serine-rich 3
, splicing factor, arginine/serine-rich, 20-kD
, splicing factor, arginine/serine-rich 3 (SRp20)
, splicing factor, arginine serine-rich 3
, splicing factor, arginine/serine-rich 3a