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C2H2-type zinc finger proteins, such as ZNF238, act on the molecular level as transcriptional activators or repressors and are involved in chromatin assembly (Becker et al., 1997 [PubMed 9568537]).[supplied by OMIM, Jan 2011].. Zusätzlich bieten wir Ihnen Zinc Finger Protein 238 Antikörper (25) und viele weitere Produktgruppen zu diesem Protein an.
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Human ZNF238 Protein expressed in Wheat germ - ABIN1326010
Mao, Ladd, Gad, Rastetter, Johnson, Marzbani, Childs, Lu, Dang, Broussard, Stanton, Hanash, Disis: Mining the pre-diagnostic antibody repertoire of TgMMTV-neu mice to identify autoantibodies useful for the early detection of human breast cancer. in Journal of translational medicine 2014
results confirm and refine the complex genotype-phenotype correlations existing in the 1qter microdeletion syndrome and define more precisely the neurodevelopmental phenotypes associated with genetic alterations of AKT3 (zeige AKT3 Proteine), ZBTB18 and HNRNPU (zeige HNRNPU Proteine) in humans
De novo missense and truncating variants in ZBTB18 cause intellectual disability.
This report indicates that haploinsufficiency of additional genes beside ZBTB18 causes the high frequency of corpus callosum anomalies in patients with microdeletions of 1q43q44 and underlines the importance of an NGS-based molecular diagnostic in complex phenotypes
repression of the CR2/CD21 (zeige CR2 Proteine) promoter can occur through one of the E-box motifs via recruitment of RP58.
RP58 may act to favor neuronal differentiation and brain growth by coherently repressing multiple proneurogenic genes in a timely manner.
Findings indicate that ZNF238 is a novel brain tumor suppressor and its reactivation in tumors could open a novel anticancer strategy.
Disruption of RP58 expression alters the differentiation of immature neurons and impairs their migration and positioning within the mouse cerebral cortex.
RP58 represses Ngn2 (zeige NEUROG2 Proteine) transcription to regulate the Ngn2 (zeige NEUROG2 Proteine)-Rnd2 (zeige RND2 Proteine) pathway; Ngn2 (zeige NEUROG2 Proteine) knockdown rescued migration defects of the RP58(-/-) neurons.
Rp58 is essential for the growth and organization of the cerebellum and regulates the development of both GABAergic and glutamatergic neurons.
This study showed that Cre recombinase (zeige RAG1 Proteine) expression under the control of the RP58 gene promoter is a feasible tool for conditional gene switching in post-mitotic multipolar migrating young neurons in the developing cerebral cortex.
The authors report that a transcriptional factor, RP58, negatively regulates all four Id genes (Id1 (zeige ID1 Proteine)-Id4 (zeige ID4 Proteine)) in developing cerebral cortex.
Data show that inhibition of ZNF238 (RP58) expression in mouse GNPs decreases the expression of the neuronal differentiation markers MAP2 and NeuN (zeige RBFOX3 Proteine) and downregulates the expression of the cell cycle arrest protein p27 (zeige CDKN1B Proteine), a regulator of GNP differentiation.
The combined systems approach identified RP58 as an effector included in MyoD (zeige MYOD1 Proteine)-activated positive feedback and enabling progression of skeletal myogenesis by repressing expression of Id2 and Id3 (zeige ID3 Proteine), inhibitors of myogenesis.
These results suggest that RP58 plays a crucial role in neuronal proliferation, migration, and differentiation in the developing cerebral cortex.
Interestingly, co-transfection with simiRP58 (zeige ZBTB42 Proteine) and RP58 induced changes in the localization patterns of both proteins.
C2H2-type zinc finger proteins, such as ZNF238, act on the molecular level as transcriptional activators or repressors and are involved in chromatin assembly (Becker et al., 1997
BTB/POZ domain protein ZF238
, novel zinc finger domain containing protein
, zinc finger and BTB domain-containing protein 18
, zinc finger protein 238
, 58 kDa repressor protein
, transcriptional repressor RP58
, translin-associated zinc finger protein 1
, zinc finger protein C2H2-171