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YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. Zusätzlich bieten wir Ihnen YY1 Transcription Factor Antikörper (149) und YY1 Transcription Factor Proteine (8) und viele weitere Produktgruppen zu diesem Protein an.
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YY1 is essential for Xenopus development in neural ectoderm differentiation, neural crest specification and directing neural crest mesenchyme formation by blocking slug
Yin Yang 1 transcription factor assembly into messenger ribonucleoprotein (zeige RBP31 ELISA Kits) particles requires direct RNA binding activity
Results show that the YY1-RNA interaction is highly stable, and that YY1 possesses the ability to interact with structurally divergent RNA substrates.
results suggest that YY1a regulates PS receptor expression that linked to function of PSR (zeige JMJD6 ELISA Kits)-phagocyte mediated apoptotic cell engulfment during development
YY1 promotes zebrafish liver steatosis and lipotoxicity by inhibiting CHOP-10 (zeige DDIT3 ELISA Kits) expression.
Study demonstrated that beta-arrestin1 (zeige ARRB1 ELISA Kits) is critically involved in zebrafish primitive hematopoiesis, where beta-arrestin1 (zeige ARRB1 ELISA Kits) binds to and sequesters the PcG recruiter YY1, thus relieving PcG-mediated repression of cdx4-hox (zeige MSH2 ELISA Kits) pathway.
Study shows that the ubiquitously expressed transcription factor Yin Yang 1 (YY1) contributes to enhancer-promoter structural interactions in a manner analogous to DNA interactions mediated by CTCF (zeige CTCF ELISA Kits).
YY1 was over-expressed in RA which can bind to the promotor of IL-6 (zeige IL6 ELISA Kits) to introduce IL-6 (zeige IL6 ELISA Kits) expression, contributing to the inflammation of RA via stimulation of Th17 differentiation.
YY1 promotes apoptosis via upregulating Bax (zeige BAX ELISA Kits) transcription and subsequent activation of Bax (zeige BAX ELISA Kits) by translocation from the cytosol to the mitochondrial membrane.
High YY1 expression is associated with Lung Cancer Progression.
Low YY1 expression is associated with pancreatic ductal adenocarcinoma.
PRE-PIK3C2B interacts directly with YY1 in vitro and recruits PRC2 complex in vivo. The localization of PcG proteins including YY1 to PRE-PIK3C2B in HEK cells is decreased on knock-down of either YY1 or SUZ12.
YY1 promotes mTORC2 (zeige CRTC2 ELISA Kits)-mediated AKT (zeige AKT1 ELISA Kits) activation
Yin Yang 1 (YY1) interacts with Seryl-tRNA synthetase (SerRS (zeige SARS ELISA Kits)) to form a SerRS (zeige SARS ELISA Kits)/YY1 complex which functions as a negative effector to regulate vegfa (zeige VEGFA ELISA Kits) transcription through binding a distal segment of the vegfa (zeige VEGFA ELISA Kits) promoter, while NFKB1 (zeige NFKB1 ELISA Kits) serves as a positive effector through outcompeting SerRS (zeige SARS ELISA Kits)/YY1 for binding at the same distal segment.
these results define a clinical syndrome caused by haploinsufficiency of YY1 through dysregulation of key transcriptional regulators.
Interactions of the chromatin remodeling protein INO80 (zeige INO80 ELISA Kits) with DNA, and the role of YY1 in this process have been described.
these results suggested that the basal promoter activity of the mIRF-3 gene is regulated by transcription factors Egr2 (zeige EGR2 ELISA Kits) and YY1 in NIH3T3 cells
DNA binding domain of YY1 is necessary for X-chromosome inactivation in activated B cells, as ex-vivo YY1 deletion results in loss of inactive X (Xi) chromosome heterochromatin marks and up-regulation of X-linked genes.
Transcriptome analysis revealed that YY1 is required for mitochondrial gene expression, and ultrastructural analysis confirmed compromised mitochondrial integrity in the mutant intestine.
regulates broad general processes throughout all stages of B-cell differentiation: normally activates genes involved in mitochondrial bioenergetics; normally down-regulates genes involved in transcription, mRNA splicing, NF-kappaB (zeige NFKB1 ELISA Kits) signaling pathways, the AP-1 (zeige JUN ELISA Kits) transcription factor network, chromatin remodeling, cytokine signaling pathways, cell adhesion, and cell proliferation
Results indicate that YY1 plays an important role in regulating the balance between dark zone and light zone cells in germinal center (GCs (zeige UGCG ELISA Kits)) and between survival and death of GC B (zeige NPR2 ELISA Kits) cells.
YY1 is required for germinal center B cell development.
Dp71 (zeige DMD ELISA Kits) expression in hepatic cells is carried out, in part, by YY1-, Sp1 (zeige SP1 ELISA Kits)- and Sp3 (zeige SP3 ELISA Kits)-mediated transcription from the Dp71 (zeige DMD ELISA Kits) promoter.
this study shows that YY1 regulates the formation of terminal-effector CD8 (zeige CD8A ELISA Kits)+ T cell fates
that yin yang 1 strongly localizes in the spermatogonial stem cells and co-localizes heterogeneously with CP2c to permit spermatogenesis
YY1 and SP1 independently and cooperatively govern the Mesp1 expression during embryogenesis.
YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters. YY1 may direct histone deacetylases and histone acetyltransferases to a promoter in order to activate or repress the promoter, thus implicating histone modification in the function of YY1.
YY1 transcription factor
, YY1 transcription factor, like
, transcription factor YY1
, Yin Yang 1
, INO80 complex subunit S
, Yin and Yang 1 protein
, delta transcription factor
, transcriptional repressor protein YY1
, GLI-Krupple related protein
, UCR-motif DNA-binding protein
, UCRBP transcription factor
, yin and yang 1