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WNK1 encodes a member of the WNK subfamily of serine/threonine protein kinases. Zusätzlich bieten wir Ihnen WNK1 Antikörper (185) und WNK1 Kits (7) und viele weitere Produktgruppen zu diesem Protein an.
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A new WNK1/HSN2 founder mutation has been found in Japanese patients with hereditary sensory and autonomic neuropathy.
Small interfering RNA knockdown of MAPK7 (zeige MAPK7 Proteine) demonstrated that MAPK7 (zeige MAPK7 Proteine) regulates a subset of WNK1-regulated genes and controls the migration and cell proliferation
The AA genotype of WNK1 rs1468326 is related with an increased risk for preeclampsia.
Mutated WNK1 is a driver of chronic lymphocytic leukemia.
Using small-interfering RNA-mediated WNK1 knockdown, we show autophagosome formation and autophagic flux are accelerated. In cells with reduced WNK1, basal and starvation-induced autophagy is increased. We also show that depletion of WNK1 stimulates focal class III phosphatidylinositol 3-kinase complex (PI3KC3) activity, which is required to induce autophagy.
WNK1 and the associated phosphorylation of the PCF11 CID act to promote transcript release from chromatin-associated Pol II, which in turn facilitates mRNA export to the cytoplasm
Akt3 (zeige AKT3 Proteine) constitutively suppresses macropinocytosis in macrophages through a novel WNK1/SGK1 (zeige SGK1 Proteine)/Cdc42 (zeige CDC42 Proteine) pathway.
NKCC1 (zeige SLC12A2 Proteine) and KCCs are coordinately regulated by L-WNK1 isoforms.
Single nucleotide polymorphisms STK39 (zeige STK39 Proteine) and WNK were associated with hypertension and BP in our multicenter Belgian case-control study
these data provide insight into the mechanism regulating Cl(-) homeostasis in immature neurons, and suggest that WNK1-regulated changes in KCC2 (zeige SLC12A5 Proteine) phosphorylation contribute to the developmental excitatory-to-inhibitory GABA sequence.
HSN2 is a nervous system-specific exon of the WNK1 gene (WNK1/HSN2 isoform).
The differential regulation of ROMK (zeige KCNJ1 Proteine), large-conductance Ca(2 (zeige CA2 Proteine)+)-activated K(+) (BK) channel (zeige KCNMA1 Proteine), BK-alpha and NKCC2 (zeige SLC12A1 Proteine) between female and male mice, at least, were partly mediated via WNK1 pathway, which may contribute to the sexual dimorphism of plasma K(+) and blood pressure control.
this study identified the WNK1 kinase as a regulator of both integrin-mediated adhesion and T cell migration
Electrophysiological analysis showed that WNK1/HSN2 shifted the concentration of Cl(-)such that GABA signaling resulted in a less hyperpolarized state (increased neuronal activity) rather than a more hyperpolarized state (decreased neuronal activity) in mouse spinal nerves.
A high-K(+) diet induced an increase in L-WNK1 expression selectively in intercalated cells and may contribute to enhanced BK channel (zeige KCNMA1 Proteine) expression and K(+) secretion in collecting ducts.
findings indicate that the proline-rich exons are modular cassettes that convert WNK1 into a NEDD4-2 (zeige NEDD4L Proteine) substrate, thereby linking aldosterone and other NEDD4-2 (zeige NEDD4L Proteine)-suppressing antinatriuretic hormones to NCC (zeige SLC12A3 Proteine) phosphorylation status.
enhances BK channel function by reducing ERK1/2 signaling-mediated lysosomal degradation of the channel
increased protein expression levels of WNK1 and WNK4 (zeige WNK4 Proteine) kinases cause PHAII by KLHL3 (zeige KLHL3 Proteine) R528H mutation due to impaired KLHL3 (zeige KLHL3 Proteine)-Cullin3-mediated ubiquitination.
study identifies a separation of functions for the WNK1-activated protein kinases OSR1 (zeige OSR1 Proteine) and SPAK (zeige STK39 Proteine) in mediating proliferation, invasion, and gene expression in endothelial cells
This gene encodes a member of the WNK subfamily of serine/threonine protein kinases. The encoded protein may be a key regulator of blood pressure by controlling the transport of sodium and chloride ions. Mutations in this gene have been associated with pseudohypoaldosteronism type II and hereditary sensory neuropathy type II. Alternatively spliced transcript variants encoding different isoforms have been described but the full-length nature of all of them has yet to be determined.
WNK lysine deficient protein kinase 1 isoform
, erythrocyte 65 kDa protein
, prostate-derived sterile 20-like kinase
, protein kinase with no lysine 1
, serine/threonine-protein kinase WNK1
, WNK lysine deficient protein kinase 1
, serine/threonine-protein kinase WNK1-like
, protein kinase lysine-deficient 1