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URG4 is upregulated in the presence of hepatitis B virus (HBV)-encoded X antigen (HBxAg) and may contribute to the development of hepatocellular carcinoma by promoting hepatocellular growth and survival (Tufan et al., 2002 [PubMed 12082552]).[supplied by . Zusätzlich bieten wir Ihnen Upregulator of Cell Proliferation Antikörper (63) und Upregulator of Cell Proliferation Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.
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miR (zeige MLXIP ELISA Kits)-519 inhibited URG4 expression by directly binding to the 3'UTR (zeige UTS2R ELISA Kits) of URG4. miR (zeige MLXIP ELISA Kits)-519 inhibited Cyclin D1 (zeige CCND1 ELISA Kits) expression and the phosphorylation level of Rb, and increased p21 (zeige CDKN1A ELISA Kits) and p27 (zeige PAK2 ELISA Kits) expression, confirming miR (zeige MLXIP ELISA Kits)-519 blocked G1/S transition.
Findings indicate that URGCP plays an important role in promoting NSCLC cell invasion and metastasis by enhancing NF-kappaB (zeige NFKB1 ELISA Kits)-activated MMP-9 (zeige MMP9 ELISA Kits) expression
site-directed mutagenesis of potential SP1 (zeige PSG1 ELISA Kits) binding sites diminished both DNA-protein complexes and SP1 (zeige PSG1 ELISA Kits)-mediated upregulation of URG-4 promoter activity. These findings are valuable for understanding transcriptional regulation of URG4/URGCP that has a pivotal role in cancer progression.
FA caused a decrease in the expression of novel gene URG4/URGCP.
URG4 overexpression increased the resistance to cisplatin-induced apoptosis in bladder cancer.
We presented first mechanisms of TMZ and URG4/URGCP relationship in neuroblastoma cells in this study. As a result, TMZ may be a novel candidate agent for treatment of neuroblastoma as a single or agent or together with other therapeutic agents
This study suggests that URG4/URGCP plays an important pro-angiogenic role in HCC via a mechanism linked to activation of the NF-kappaB (zeige NFKB1 ELISA Kits) pathway
URG4 overexpression is correlated with cervical cancer progression and poor prognosis in patients with early-stage cervical cancer.
Data suggest that neuroblastoma (NB) cell differentiation might associate with peroxisome proliferator-activated receptor alpha (PPARalpha (zeige PPARA ELISA Kits)) and URG4/URGCP gene expression profile after retinoic acid (RA) treatment.
Rapamycin diminishes URGCP gene expression in DU145 and PC3 cells, but increases expression in LNCaP cells.
URG4 is upregulated in the presence of hepatitis B virus (HBV)-encoded X antigen (HBxAg) and may contribute to the development of hepatocellular carcinoma by promoting hepatocellular growth and survival (Tufan et al., 2002
upregulator of cell proliferation
, up-regulator of cell proliferation
, Protein URG4
, up-regulated gene 4
, HBxAg up-regulated gene 4 protein homolog
, HBV X protein up-regulated gene 4 protein homolog
, HBV X protein up-regulated gene 4 protein
, HBxAg up-regulated gene 4 protein
, protein URG4