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URG4 is upregulated in the presence of hepatitis B virus (HBV)-encoded X antigen (HBxAg) and may contribute to the development of hepatocellular carcinoma by promoting hepatocellular growth and survival (Tufan et al., 2002 [PubMed 12082552]).[supplied by . Zusätzlich bieten wir Ihnen Upregulator of Cell Proliferation Antikörper (67) und Upregulator of Cell Proliferation Proteine (5) und viele weitere Produktgruppen zu diesem Protein an.
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Relationship between URG4/URGCP expression and clinicopathologic characteristics were evaluated and significant results were in various cancer types (review).
miR-519 inhibited URG4 expression by directly binding to the 3'UTR of URG4. miR-519 inhibited Cyclin D1 expression and the phosphorylation level of Rb, and increased p21 and p27 expression, confirming miR-519 blocked G1/S transition.
Findings indicate that URGCP plays an important role in promoting NSCLC cell invasion and metastasis by enhancing NF-kappaB (zeige NFKB1 ELISA Kits)-activated MMP-9 (zeige MMP9 ELISA Kits) expression
site-directed mutagenesis of potential SP1 (zeige PSG1 ELISA Kits) binding sites diminished both DNA-protein complexes and SP1 (zeige PSG1 ELISA Kits)-mediated upregulation of URG-4 promoter activity. These findings are valuable for understanding transcriptional regulation of URG4/URGCP that has a pivotal role in cancer progression.
FA caused a decrease in the expression of novel gene URG4/URGCP.
URG4 overexpression increased the resistance to cisplatin-induced apoptosis in bladder cancer.
We presented first mechanisms of TMZ and URG4/URGCP relationship in neuroblastoma cells in this study. As a result, TMZ may be a novel candidate agent for treatment of neuroblastoma as a single or agent or together with other therapeutic agents
This study suggests that URG4/URGCP plays an important pro-angiogenic role in HCC via a mechanism linked to activation of the NF-kappaB (zeige NFKB1 ELISA Kits) pathway
URG4 overexpression is correlated with cervical cancer progression and poor prognosis in patients with early-stage cervical cancer.
Data suggest that neuroblastoma (NB) cell differentiation might associate with peroxisome proliferator-activated receptor alpha (PPARalpha (zeige PPARA ELISA Kits)) and URG4/URGCP gene expression profile after retinoic acid (RA) treatment.
URG4 is upregulated in the presence of hepatitis B virus (HBV)-encoded X antigen (HBxAg) and may contribute to the development of hepatocellular carcinoma by promoting hepatocellular growth and survival (Tufan et al., 2002
upregulator of cell proliferation
, up-regulator of cell proliferation
, Protein URG4
, up-regulated gene 4
, HBxAg up-regulated gene 4 protein homolog
, HBV X protein up-regulated gene 4 protein homolog
, HBV X protein up-regulated gene 4 protein
, HBxAg up-regulated gene 4 protein
, protein URG4