Ubiquitin-Fold Modifier 1 Proteine (UFM1)

UFM1 is a ubiquitin-like protein that is conjugated to target proteins by E1-like activating enzyme UBA5 (UBE1DC1\; MIM 610552) and E2-like conjugating enzyme UFC1 (MIM 610554) in a manner analogous to ubiquitylation (see UBE2M\; MIM 603173) (Komatsu et al., 2004 [PubMed 15071506]).[supplied by OMIM, Dec 2008].. Zusätzlich bieten wir Ihnen UFM1 Antikörper (12) und und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
UFM1 51569 P61960
Maus UFM1 UFM1 67890 P61961
UFM1 365797 Q5BJP3
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Top UFM1 Proteine auf antikoerper-online.de

Showing 10 out of 21 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,869.04
Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
Details
Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 15 bis 19 Tage
$400.00
Details
Hefe Xenopus tropicalis His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,123.00
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Hefe Xenopus laevis His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,123.00
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Hefe Zebrafisch His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,123.00
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Hefe Huhn His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,123.00
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Hefe Orang-Utan His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,123.00
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Hefe Rind (Kuh) His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,123.00
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Hefe Cynomolgus His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,123.00
Details

UFM1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, , ,
Rat (Rattus)

Weitere Proteine zu Ubiquitin-Fold Modifier 1 (UFM1) Interaktionspartnern

Human Ubiquitin-Fold Modifier 1 (UFM1) Interaktionspartner

  1. UFM1 His 70 resembles UBA5 (zeige UBA5 Proteine) His336 and enters a negatively charged pocked on the other UFM1 molecule.

  2. These findings explicitly elucidate the role of UBA5 (zeige UBA5 Proteine) dimerization in UFM1 activation.

  3. This study, focused on identifying the mutated gene in patients with hypomyelination with atrophy of the basal ganglia and cerebellum without TUBB4A (zeige TUBB5 Proteine) mutations, revealed a homozygous 3-bp deletion in the UFM1 promoter area, which perfectly segregates with the disease.

  4. Meta analysis identified a new gene, UFM1, that is associated with low von Willebrand factor (zeige VWF Proteine) levels.

  5. in the absence of UFSP2 (zeige C4orf20 Proteine), a deconjugating enzyme for UFM1, ectopic expression of both UFL1 (zeige UFL1 Proteine) and UFBP1, which serve as the E3-ligase complex for the UFM1-system, dramatically increases UFM1-conjugate formation at the endoplasmic reticulum.

  6. data imply that the combination of a hypomorphic p.Ala371Thr variant in trans with a loss-of-function allele in UBA5 underlies a severe infantile-onset encephalopathy

  7. Biallelic Variants in UBA5 (zeige UBA5 Proteine) Reveal that Disruption of the UFM1 Cascade Can Result in Early-Onset Encephalopathy

  8. results of an in vitro truncation assay suggest that Uba5 (zeige UBA5 Proteine) residues 57-363 comprise the minimal fragment required for the high-efficiency activation of Ufm1

  9. ASC1 (zeige RPL3 Proteine) is a target for ufmylation and that UFBP1 is an essential component for ASC1 (zeige RPL3 Proteine) ufmylation.

  10. binding of ATP to Uba5 (zeige UBA5 Proteine) approximately Ufm1 thioester was required for efficient transfer of Ufm1 from Uba5 (zeige UBA5 Proteine) to Ufc1 (zeige UFC1 Proteine) via transthiolation.

Mouse (Murine) Ubiquitin-Fold Modifier 1 (UFM1) Interaktionspartner

  1. CNS-specific knockout of Ufm1 in mice causes neonatal death accompanied by microcephaly and apoptosis in specific neurons, further suggesting that the UFM1 system is essential for CNS development and function

  2. High UFM1 expression is associated with Atherosclerosis.

  3. transcription downregulation of the Ufm1 and FAT10 (zeige UBD Proteine) conjugation system in liver Mallory-Denk bodies formation

  4. These data suggest that UFM1-UFBP1 participate in preventing ER stress-induced apoptosis in protein secretory cells.

  5. A novel type of E3 ligase for the Ufm1 conjugation system.

  6. A novel ubiquitin fold modifier (Ufm1) not been previously associated with ER stress and not found to be induced under any condition was found to be upregulated in the hearts of MCP (zeige CR1L Proteine) mice (transgenic mice that express MCP-1 (zeige CPT1B Proteine) specifically in the heart).

  7. loop between beta3 and alpha2 in addition to the C-terminal region of Ufm1 plays a role in binding to UfSP1

UFM1 Protein Überblick

Protein Überblick

UFM1 is a ubiquitin-like protein that is conjugated to target proteins by E1-like activating enzyme UBA5 (UBE1DC1\; MIM 610552) and E2-like conjugating enzyme UFC1 (MIM 610554) in a manner analogous to ubiquitylation (see UBE2M\; MIM 603173) (Komatsu et al., 2004

Genbezeichner und Symbole assoziert mit UFM1

  • ubiquitin fold modifier 1 (UFM1)
  • ubiquitin-fold modifier 1 (ufm1)
  • ubiquitin-fold modifier (CCP2)
  • ubiquitin fold modifier 1 (ufm1)
  • ubiquitin-fold modifier 1 (Ufm1)
  • ubiquitin-fold modifier 1 L homeolog (ufm1.L)
  • ubiquitin-fold modifier 1 (PR46a)
  • 1810045K17Rik Protein
  • AI132708 Protein
  • AI463323 Protein
  • bA131P10.1 Protein
  • BM-002 Protein
  • C13orf20 Protein
  • ENSMUSG00000074598 Protein
  • Gm10726 Protein
  • RGD1304890 Protein
  • T32E8.4 Protein
  • T32E8_4 Protein
  • ubfm1 Protein
  • wu:fa10f05 Protein
  • wu:fb72g01 Protein
  • zgc:55335 Protein

Bezeichner auf Proteinebene für UFM1

ubiquitin-fold modifier 1

GENE ID SPEZIES
452546 Pan troglodytes
477297 Canis lupus familiaris
549742 Xenopus (Silurana) tropicalis
695866 Macaca mulatta
844107 Arabidopsis thaliana
100528343 Ictalurus punctatus
51569 Homo sapiens
67890 Mus musculus
365797 Rattus norvegicus
530547 Bos taurus
418894 Gallus gallus
100286585 Salmo salar
100172209 Pongo abelii
495839 Xenopus laevis
322756 Danio rerio
5722153 Chlamydomonas reinhardtii
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