anti-Ubiquitin Specific Peptidase 14 (USP14) Antikörper

USP14 encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. Zusätzlich bieten wir Ihnen USP14 Proteine (14) und USP14 Kits (4) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
USP14 9097 P54578
USP14 59025 Q9JMA1
USP14 291796  
Direkt bei antikoerper-online bestellen
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Online bestellen
  • orders@antikoerper-online.de

Top anti-USP14 Antikörper auf antikoerper-online.de

Showing 10 out of 94 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Lieferzeit Preis Details
Human Maus Unkonjugiert ELISA, WB 100 μg 11 bis 14 Tage
$551.83
Details
Human Kaninchen Unkonjugiert WB WB Image Sample (30 ug of whole cell lysate) A: A431 , 10% SDS PAGE antibody diluted at 1:1000 100 μL 3 bis 4 Tage
$466.18
Details
Human Kaninchen Unkonjugiert ELISA, WB Western blot analysis USP14 using Jurkat whole cell lysates 100 μL 11 bis 12 Tage
$390.77
Details
Human Maus Unkonjugiert IF, ELISA, WB USP14 monoclonal antibody (M04), clone 6D6 Western Blot analysis of USP14 expression in HeLa . Immunofluorescence of monoclonal antibody to USP14 on HeLa cell. [antibody concentration 20 ug/ml] 100 μg 11 bis 12 Tage
$440.00
Details
Human Kaninchen Unkonjugiert EIA, IHC (p), WB 0.4 mL 6 bis 8 Tage
$484.00
Details
Human Maus Unkonjugiert ELISA, WB USP14 monoclonal antibody (M08), clone 1F8. Western Blot analysis of USP14 expression in Hela S3 NE . Detection limit for recombinant GST tagged USP14 is approximately 1ng/ml as a capture antibody. 100 μg 11 bis 12 Tage
$440.00
Details
Human Maus Unkonjugiert ELISA, WB USP14 polyclonal antibody (A01), Lot # 060707JCS1 Western Blot analysis of USP14 expression in Jurkat . USP14 polyclonal antibody (A01), Lot # 060707JCS1. Western Blot analysis of USP14 expression in NIH/3T3. 50 μL 11 bis 12 Tage
$305.71
Details
Human Kaninchen Unkonjugiert WB Western blot analysis in A2058 cell line lysates (35ug/lane). 400 μL 2 bis 3 Tage
$515.63
Details
Human Kaninchen Unkonjugiert ICC, IHC, WB Figure. Western Blot Sample: Recombinant USP14, Human Figure.DAB staining on IHC-P. Samples: Human Tissue 100 μg 13 bis 16 Tage
$350.00
Details
Human Maus Unkonjugiert WB Western Blot analysis of USP14 expression in transfected 293T cell line by USP14 MaxPab polyclonal antibody.Lane 1: USP14 transfected lysate(54.34 KDa).Lane 2: Non-transfected lysate. USP14 MaxPab polyclonal antibody. Western Blot analysis of USP14 expression in rat brain. 50 μL 11 bis 12 Tage
$440.00
Details

Am meisten referenzierte anti-USP14 Antikörper

  1. Human Monoclonal USP14 Primary Antibody für IF, ELISA - ABIN563939 : Hyrskyluoto, Bruelle, Lundh, Do, Kivinen, Rappou, Reijonen, Waltimo, Petersén, Lindholm, Korhonen: Ubiquitin-specific protease-14 reduces cellular aggregates and protects against mutant huntingtin-induced cell degeneration: involvement of the proteasome and ER stress-activated kinase IRE1?. in Human molecular genetics 2014 (PubMed)

  2. Human Polyclonal USP14 Primary Antibody für IHC (p), ELISA - ABIN545125 : Mines, Goodwin, Limbird, Cui, Fan: Deubiquitination of CXCR4 by USP14 is critical for both CXCL12-induced CXCR4 degradation and chemotaxis but not ERK ativation. in The Journal of biological chemistry 2009 (PubMed)

Weitere Antikörper gegen USP14 Interaktionspartner

Human Ubiquitin Specific Peptidase 14 (USP14) Interaktionspartner

  1. USP14 levels were significantly increased in gastric cancer (GC) tissues compared to the paired normal tissues. USP14 level was an independent prognostic factor for DFS in GC patients. Its knockdown sensitized GC cells to cisplatin by triggering cisplatin-induced apoptosis via impeding Akt and ERK signaling pathways.

  2. USP14 directly interacted with RNF168, which depended on the MIU1 domain of RNF168. These findings identify USP14 as a novel substrate of autophagy and regulation of RNF168-dependent Ubiquitination and TP53BP1 recruitment by USP14 as a critical link between DNA damage repair and autophagy.

  3. Data show that ubiquitin-specific protease 14 (USP14) is a direct target of hsa-miR-124a, and that hsa-miR-124a inhibits stemness.

  4. Our results provide a rationale for targeting the proteasome-associated DUB USP14 to treat and combat melanomas.

  5. genetic and pharmacological inhibition of USP14 promotes mitophagy.

  6. USP14 acts as a negative regulator in antiviral response through deubiquitinating K63-linked RIG-I

  7. High USP14 expression is associated with Osteoarthritis.

  8. The proteasome-associated deubiquitinating enzyme Usp14/UBP6 contains an N-terminal ubiquitin-like UBL domain and is an important regulator of proteasomal activity. Usp14 by itself represses multiple proteasomal activities but, upon binding a ubiquitin chain, Usp14 promotes ubiquitin-conjugate degradation. Usp14's UBL domain alone mimics this activation of proteasomes by ubiquitin chains.

  9. By displacing USP14, TRIM11 changes proteasome composition and suppresses both catalytic and non-catalytic effects of USP14

  10. Usp14 and Ube3c cycle together on and off proteasomes, and the presence of ubiquitinated substrates promotes their association. This mechanism enables proteasome activity to adapt to the supply of substrates.

  11. our results demonstrated that vimentin in human GC tissues and cell lines was upregulated due to its de-ubiquitination after interactions with USP14 and miR-320a, which could promote the aggressiveness of GC cells.

  12. Study detected elevated USP14 expression at both mRNA and protein levels, and was significantly associated with distant metastasis.

  13. These findings suggested that USP14 induces NF-kappaB activity and ERK1/2 phosphorylation triggered by microbial infection.

  14. Ubiquitin-specific protease 14 regulates cell proliferation and apoptosis in oral squamous cell carcinoma

  15. our report demonstrates significant value in targeting USP14/UCHL5 with VLX1570 in drug-resistant Waldenstrom macroglobulinemia (WM) and carries a high potential for clinical translation

  16. USP14 promotes prostate cancer progression.

  17. without a ubiquitinated substrate present, Usp14 suppresses multiple proteasomal activities, especially basal ATP consumption and degradation of non-ubiquitinated proteins. These allosteric effects thus reduce ATP hydrolysis by inactive proteasomes and nonspecific proteolysis and enhance proteasomal specificity for ubiquitinated proteins.

  18. USP14 regulates autophagy by negatively controlling K63 ubiquitination of Beclin 1

  19. USP14 plays an important role in the progression and metastasis of esophageal squamous cell carcinoma.

  20. USP14 participates in CAM-DR of MM through acting as a bridge between Bcl-xl apoptotic pathway and Wnt-signaling pathways and may be represented as a good candidate for pursuing clinical trials in MM.

Mouse (Murine) Ubiquitin Specific Peptidase 14 (USP14) Interaktionspartner

  1. High USP14 expression is associated with Osteoarthritis.

  2. the data indicate that functional Usp14 enhances direct Antigen presentation, preferentially of defective ribosomal product-derived peptides, suggesting that the processing of defective ribosomal product-derived peptides is in some ways different from other forms of Antigen.

  3. The homeostasis of Ubiquitin in USP14-/-mouse embryonic fibroblasts was markedly perturbed because of facilitated clearance of Ubiquitin.

  4. Usp14 and Ube3c cycle together on and off proteasomes, and the presence of ubiquitinated substrates promotes their association. This mechanism enables proteasome activity to adapt to the supply of substrates.

  5. analysis of the molecular mechanisms through which CBP stability is regulated by FBXL19 and USP14, which results in the modulation of chromatin remodeling and the expression of cytokine-encoding genes

  6. These findings suggested that USP14 induces NF-kappaB activity and ERK1/2 phosphorylation triggered by microbial infection.

  7. without a ubiquitinated substrate present, Usp14 suppresses multiple proteasomal activities, especially basal ATP consumption and degradation of non-ubiquitinated proteins. These allosteric effects thus reduce ATP hydrolysis by inactive proteasomes and nonspecific proteolysis and enhance proteasomal specificity for ubiquitinated proteins.

  8. USP14's catalytic activity is required for nervous system structure and function and has an ongoing role in NMJ synaptic transmission. USP14 regulation of the ubiquitination status of protein kinases, coordinates NMJ intracellular signaling pathways.

  9. Overexpression of the Usp14 reduces cellular aggregates in mutant Htt-expressing cells mainly via the ubiquitin proteasome system.

  10. USP14 modulates hippocampal short-term plasticity and vesicle number independent of its deubiquitinating activity.

  11. Differences in genetic background were shown to affect ubiquitin expression and dramatically alter the phenotypes caused by USP14 deficiency.

  12. Data indicate that increased levels of phosphorylated tau correlated with the onset of axonal varicosities in the ubiquitin-specific protease 14 (Usp14)-deficient mice.

  13. miR-124 promotes neuronal survival under ischemic conditions via Usp14-dependent REST degradation.

  14. overexpression of HA-USP14 increased TNFalpha

  15. Oxidative stress increasd USP14 expression, and beta-carotene dose-dependently inhibited increased expression in mouse skeletal muscle myotubes.

  16. ubiquitinated loosely folded proteins, after becoming bound to the 26 S, interact with Ubp6/Usp14 or Uch37 to activate ATP hydrolysis and enhance their own destruction

  17. USP14 has a role in regulating synaptic activity in mammals

  18. Usp14 functions to maintain the cellular levels of monomeric ubiquitin in mammalian cells, and that alterations in the levels of ubiquitin may contribute to neurological disease

  19. Results suggest that Uch-L1 and Usp14 may differentially affect the ubiquitin proteasome system and synaptic activity by regulating different pools of ubiquitin in the cell.

  20. A mutated axJ gene locus, encoding the ubiquitin-specific protease 14 (Usp14), negatively influences GABAA receptor turnover.

USP14 Antigen-Profil

Protein Überblick

This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. Mice with a mutation that results in reduced expression of the ortholog of this protein are retarded for growth, develop severe tremors by 2 to 3 weeks of age followed by hindlimb paralysis and death by 6 to 10 weeks of age. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Genbezeichner und Symbole assoziert mit USP14

  • ubiquitin specific peptidase 14 (USP14) Antikörper
  • peptidase C19 family protein (usp14) Antikörper
  • ubiquitin specific peptidase 14 (Usp14) Antikörper
  • ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) (usp14) Antikörper
  • ubiquitin specific protease 14 (Bm1_28765) Antikörper
  • ubiquitin specific peptidase 14 S homeolog (usp14.S) Antikörper
  • ubiquitin specific peptidase 14 (usp14) Antikörper
  • universal stress protein (RR_RS06480) Antikörper
  • Ubiquitin carboxyl-terminal hydrolase 14 (usp-14) Antikörper
  • 2610005K12Rik Antikörper
  • 2610037B11Rik Antikörper
  • AW107924 Antikörper
  • ax Antikörper
  • C78769 Antikörper
  • DDBDRAFT_0202821 Antikörper
  • DDBDRAFT_0237695 Antikörper
  • DDB_0202821 Antikörper
  • DDB_0237695 Antikörper
  • MGC69343 Antikörper
  • MGC81945 Antikörper
  • tgt Antikörper
  • USP14 Antikörper
  • wu:fk63d09 Antikörper
  • zgc:55949 Antikörper

Bezeichner auf Proteinebene für USP14

deubiquitinating enzyme 14 , tRNA-guanine transglycosylase, 60-kD subunit , ubiquitin carboxyl-terminal hydrolase 14 , ubiquitin specific protease 14 (tRNA-guanine transglycosylase) , ubiquitin thioesterase 14 , ubiquitin thiolesterase 14 , ubiquitin-specific processing protease 14 , ubiquitin-specific-processing protease 14 , ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) , ubiquitin domain-containing protein , ataxia , dUB-type TGT for deubiquitinating enzyme , ubiquitin specific protease 14 , universal stress protein , queuine tRNA-ribosyltransferase , ubiquitin carboxyl-terminal hydrolase 14-like

GENE ID SPEZIES
9097 Homo sapiens
100090009 Ornithorhynchus anatinus
8617881 Dictyostelium discoideum AX4
59025 Mus musculus
291796 Rattus norvegicus
335736 Danio rerio
455325 Pan troglodytes
505106 Bos taurus
6100653 Brugia malayi
421063 Gallus gallus
447733 Xenopus laevis
448110 Xenopus (Silurana) tropicalis
480182 Canis lupus familiaris
698087 Macaca mulatta
3130489 Haloarcula marismortui ATCC 43049
100009078 Oryctolagus cuniculus
100013535 Monodelphis domestica
100394297 Callithrix jacchus
100473541 Ailuropoda melanoleuca
100586916 Nomascus leucogenys
175105 Caenorhabditis elegans
Ausgewählte Anbieter für anti-USP14 (USP14) Antikörper
Haben Sie etwas anderes gesucht?