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U2 auxiliary factor (U2AF), comprised of a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. Zusätzlich bieten wir Ihnen U2 Small Nuclear RNA Auxiliary Factor 2 Antikörper (59) und viele weitere Produktgruppen zu diesem Protein an.
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Perturbation of U2AF65/NXF1 (zeige NXF1 Proteine)-mediated RNA nuclear export enhances RNA toxicity in polyQ diseases.
dephosphorylation of pS776-ATXN1 (zeige ATXN1 Proteine) by PP2A (zeige PPP2R2B Proteine) regulates the interaction of ATXN1 (zeige ATXN1 Proteine) with the splicing factors RBM17 (zeige RBM17 Proteine) and U2AF65
Using a yeast two-hybrid system, we found fourteen U2AF(65)-interacting proteins. The validity of the screen was confirmed by identification of five known U2AF(65)-interacting proteins, including its heterodimeric partner, U2AF(35 (zeige U2AF1 Proteine)).
In vivo binding of U2AF(65) to a polypyrimidine tract requires a flexible RNA backbone.
the most discriminant differences between lincRNAs and mRNAs involve splicing. LincRNAs are less efficiently spliced, which cannot be explained by differences in U1 binding or the density of exonic splicing enhancers but may be partially attributed to lower U2AF65 binding and weaker splicing-related motifs.
RBM39 (zeige RBM39 Proteine) is extensively involved in alternative splicing of RNA and helps regulate transcript levels. RBM39 (zeige RBM39 Proteine) may modulate alternative splicing similarly to U2AF65 by either directly binding to RNA or recruiting other splicing factors, such as U2AF65.
These findings uncovered a hitherto unappreciated function of CD82 (zeige CD82 Proteine) in severing the linkage between U2AF2-mediated CD44 (zeige CD44 Proteine) alternative splicing and cancer aggressiveness, with potential prognostic and therapeutic implications in melanoma
JMJD6 (zeige JMJD6 Proteine) regulated a large set of alternative splicing events, and importantly, its regulated splicing events were significantly overlapped those controlled by U2AF65.
This study therefore establishes a structural basis for specific UHM-ULM interactions by splicing factors such as U2AF35 (zeige U2AF1 Proteine), U2AF65, RBM39 (zeige RBM39 Proteine) and SF3b155 (zeige SF3B1 Proteine), and a platform for continued studies of intermolecular interactions governing disease-related alternative splicing in eukaryotic cells.
The U2AF(65) linker residues between the dual RNA recognition motifs (RRMs) recognize the central nucleotide, whereas the N- and C-terminal RRM extensions recognize the 3' terminus and third nucleotide.
Nuclear retention of full-length HTT (zeige HTT Proteine) RNA is mediated by splicing factors MBNL1 (zeige MBNL1 Proteine) and U2AF65
U2AF(65) possesses a splicing Inhibitory function that leads to alternative exon skipping.
The spatial distribution of U2AF65 conformations is found to be highly anisotropic, comprising significantly populated interdomain contacts that appear to be electrostatic in origin.
reduced U2AF(65) binding is a molecular consequence of disease-relevant mutations, and a structure-guided U2AF(65) variant is capable of manipulating gene expression in eukaryotic cells
U2 auxiliary factor (U2AF), comprised of a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the U2AF large subunit which contains a sequence-specific RNA-binding region with 3 RNA recognition motifs and an Arg/Ser-rich domain necessary for splicing. The large subunit binds to the polypyrimidine tract of introns early during spliceosome assembly. Multiple transcript variants have been detected for this gene, but the full-length natures of only two have been determined to date.
U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 2
, U2 small nuclear RNA auxiliary factor 2
, RNA-binding region RNP-1 domain-containing protein
, U2 snRNP auxiliary factor large subunit
, Splicing factor U2AF 65 kDa subunit
, U2 auxiliary factor 65 kDa subunit
, U2 small nuclear ribonucleoprotein auxiliary factor (U2AF), 65 kDa
, splicing factor U2AF 65 kDa subunit
, splicing factor U2AF large chain
, U2 (RNU2) small nuclear RNA auxiliary factor 2
, U2 small nuclear ribonucleoprotein auxiliary factor (65kD)