U2 Small Nuclear RNA Auxiliary Factor 2 Proteine (U2AF59)

U2 auxiliary factor (U2AF), comprised of a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. Zusätzlich bieten wir Ihnen U2 Small Nuclear RNA Auxiliary Factor 2 Antikörper (59) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
U2AF59 22185 P26369
U2AF59 11338 P26368
Ratte U2AF59 U2AF59 308335  
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$9,626.73
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Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$9,626.73
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
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U2AF59 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine)

Human ,
,

Weitere Proteine zu U2 Small Nuclear RNA Auxiliary Factor 2 (U2AF59) Interaktionspartnern

Mouse (Murine) U2 Small Nuclear RNA Auxiliary Factor 2 (U2AF59) Interaktionspartner

  1. Perturbation of U2AF65/NXF1-mediated RNA nuclear export enhances RNA toxicity in polyQ diseases.

  2. dephosphorylation of pS776-ATXN1 by PP2A regulates the interaction of ATXN1 with the splicing factors RBM17 and U2AF65

  3. Using a yeast two-hybrid system, we found fourteen U2AF(65)-interacting proteins. The validity of the screen was confirmed by identification of five known U2AF(65)-interacting proteins, including its heterodimeric partner, U2AF(35).

Xenopus laevis U2 Small Nuclear RNA Auxiliary Factor 2 (U2AF59) Interaktionspartner

  1. In vivo binding of U2AF(65) to a polypyrimidine tract requires a flexible RNA backbone.

Human U2 Small Nuclear RNA Auxiliary Factor 2 (U2AF59) Interaktionspartner

  1. Data show that trans-acting RNA-binding proteins (RBPs) extensively regulate U2 (RNU2) small nuclear RNA auxiliary factor 2 protein (U2AF2) binding in vivo, including enhanced recruitment to 3' splice sites and clearance of introns

  2. Data suggest that one way heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1) regulates exon definition is to modulate the interaction of U2 small nuclear RNA auxiliary factor 2 (U2AF2) with decoy or bona fide 3' splice site (3'ss).

  3. In summary, we provide insight into the underlying molecular mechanism of U2AF binding to 3' splice sites.

  4. the most discriminant differences between lincRNAs and mRNAs involve splicing. LincRNAs are less efficiently spliced, which cannot be explained by differences in U1 binding or the density of exonic splicing enhancers but may be partially attributed to lower U2AF65 binding and weaker splicing-related motifs.

  5. RBM39 is extensively involved in alternative splicing of RNA and helps regulate transcript levels. RBM39 may modulate alternative splicing similarly to U2AF65 by either directly binding to RNA or recruiting other splicing factors, such as U2AF65.

  6. These findings uncovered a hitherto unappreciated function of CD82 in severing the linkage between U2AF2-mediated CD44 alternative splicing and cancer aggressiveness, with potential prognostic and therapeutic implications in melanoma

  7. JMJD6 regulated a large set of alternative splicing events, and importantly, its regulated splicing events were significantly overlapped those controlled by U2AF65.

  8. This study therefore establishes a structural basis for specific UHM-ULM interactions by splicing factors such as U2AF35, U2AF65, RBM39 and SF3b155, and a platform for continued studies of intermolecular interactions governing disease-related alternative splicing in eukaryotic cells.

  9. The U2AF(65) linker residues between the dual RNA recognition motifs (RRMs) recognize the central nucleotide, whereas the N- and C-terminal RRM extensions recognize the 3' terminus and third nucleotide.

  10. Nuclear retention of full-length HTT RNA is mediated by splicing factors MBNL1 and U2AF65

  11. Serum RNU2-1f may serve as a biomarker for lung cancer detection, prognosis prediction and treatment monitoring.

  12. U2AF(65) possesses a splicing Inhibitory function that leads to alternative exon skipping.

  13. The spatial distribution of U2AF65 conformations is found to be highly anisotropic, comprising significantly populated interdomain contacts that appear to be electrostatic in origin.

  14. reduced U2AF(65) binding is a molecular consequence of disease-relevant mutations, and a structure-guided U2AF(65) variant is capable of manipulating gene expression in eukaryotic cells

  15. We demonstrated that PRPF40B interacts directly with SF1 and associates with U2AF(65

  16. U2AF has the capacity to directly define ~88% of functional 3' splice sites in the human genome; numerous U2AF binding events also occur in intronic locations.

  17. U2AF65 represents a new route for modulating TRF1 function at telomeres.

  18. The conserved SPSP motif phosphorylation and the SF1/U2AF interface are essential in vivo.

  19. The results highlight both local and global conformational selection as a means for universal 3' splice site recognition by U2AF65.

  20. The REST N exon is a very versatile sequence with a complex array of splicing signals, and its activation in H69 cells depends on the relative amounts of hnRNP H and U2AF65.

U2 Small Nuclear RNA Auxiliary Factor 2 (U2AF59) Protein Überblick

Protein Überblick

U2 auxiliary factor (U2AF), comprised of a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the U2AF large subunit which contains a sequence-specific RNA-binding region with 3 RNA recognition motifs and an Arg/Ser-rich domain necessary for splicing. The large subunit binds to the polypyrimidine tract of introns early during spliceosome assembly. Multiple transcript variants have been detected for this gene, but the full-length natures of only two have been determined to date.

Genbezeichner und Symbole assoziert mit U2AF59

  • U2 small nuclear RNA auxiliary factor 2 (u2af2)
  • U2 small nuclear RNA auxiliary factor 2 (U2AF2)
  • RNA recognition motif-containing protein RRM (u2af2)
  • Splicing factor U2AF 65 kDa subunit (u2af2)
  • U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 2 (U2af2)
  • U2 small nuclear RNA auxiliary factor 2 S homeolog (u2af2.S)
  • U2 small nuclear RNA auxiliary factor 2 (U2af2)
  • 65kDa Protein
  • DDBDRAFT_0186947 Protein
  • DDBDRAFT_0233353 Protein
  • DDB_0186947 Protein
  • DDB_0233353 Protein
  • U2AF2 Protein
  • U2AF65 Protein

Bezeichner auf Proteinebene für U2AF59

U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 2 , U2 small nuclear RNA auxiliary factor 2 , RNA-binding region RNP-1 domain-containing protein , U2 snRNP auxiliary factor large subunit , Splicing factor U2AF 65 kDa subunit , U2 auxiliary factor 65 kDa subunit , U2 small nuclear ribonucleoprotein auxiliary factor (U2AF), 65 kDa , splicing factor U2AF 65 kDa subunit , splicing factor U2AF large chain , U2 (RNU2) small nuclear RNA auxiliary factor 2 , U2 small nuclear ribonucleoprotein auxiliary factor (65kD) , hU2AF65

GENE ID SPEZIES
549752 Xenopus (Silurana) tropicalis
703269 Macaca mulatta
8625590 Dictyostelium discoideum AX4
100380519 Salmo salar
22185 Mus musculus
380287 Xenopus laevis
11338 Homo sapiens
100687048 Canis lupus familiaris
507895 Bos taurus
308335 Rattus norvegicus
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