Tyrosinase  Proteine (TYR)

The enzyme encoded by TYR catalyzes the first 2 steps, and at least 1 subsequent step, in the conversion of tyrosine to melanin. Zusätzlich bieten wir Ihnen Tyrosinase  Antikörper (280) und Tyrosinase  Kits (65) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
TYR 7299 P14679
TYR 22173 P11344
TYR 308800  
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Showing 10 out of 15 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 50 bis 55 Tage
Insektenzellen Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Anmelden zum Anzeigen 50 bis 55 Tage
Escherichia coli (E. coli) Wildschwein His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
Escherichia coli (E. coli) Human His-SUMO Tag 100 μg Anmelden zum Anzeigen 11 Days
Hefe Human His tag 100 μg Anmelden zum Anzeigen 8 bis 11 Tage
Escherichia coli (E. coli) Schwein Unkonjugiert SDS-PAGE analysis of Pig Tyrosinase Protein. 100 μg Anmelden zum Anzeigen 11 bis 18 Tage
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 11 Days
Wheat germ Human GST tag 2 μg Anmelden zum Anzeigen 11 bis 12 Tage
Hefe Cat His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
Hefe REACT_Pelodiscus sinensis japonicus His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage

TYR Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , , ,
, , , ,
Mouse (Murine)
Rat (Rattus)

Weitere Proteine zu Tyrosinase  (TYR) Interaktionspartnern

Zebrafish Tyrosinase  (TYR) Interaktionspartner

  1. Retinal pigment epithelium (which normally expresses tyrosinase) secretes a modulatory factor, possibly L-DOPA, which regulates light adaptation in the retinal circuitry.

Atlantic Salmon (Salmo salar) Tyrosinase  (TYR) Interaktionspartner

  1. Transcription of the tyrosinase gene family in an Atlantic salmon leukocyte cell line (SHK-1) is influenced by temperature, but not by virus infection or bacterin stimulation.

Human Tyrosinase  (TYR) Interaktionspartner

  1. immunohistochemical expression pattern of tyrosinase in different histological types of acquired dysplastic melanocytic nevi, including junctional, compound, and intradermal nevi

  2. These results suggest that TYR c.307T>C mutation might be responsible for Oculocutaneous albinism (OCA), and our study further expands the mutation spectrum of OCA1 in the Chinese population

  3. Of six probands with only a single heterozygous mutation in TYR, all were found to have the two common variants S192Y and R402Q. Our results suggest that a combination of R402Q and S192Y with a deleterious mutation in a 'tri-allelic genotype' can account for missing heritability in some hypomorphic OCA1 albinism phenotypes.

  4. Membrane-associated human tyrosinase is an enzymatically active monomeric glycoprotein.

  5. The effect of histidine mutations on the structural stability of human tyrosinase leading to albinism has been reported.

  6. Compound heterozygous mutations (c.832C>T and c.929_930insC) in the TYR gene may be responsible for partial clinical manifestations of oculocutaneous albinism

  7. Mutations in tyrosinase gene is associated with Oculocutaneous albinism type 1.

  8. tyrosinase as a potential GPR143 binding protein opens new avenues for investigating the mechanisms that regulate pigmentation and neurogenesis.

  9. Aberrant tyrosinase expression in an atypical fibroxanthoma

  10. Findings suggested that miR-330-5p represents a potential tumor-suppressive miRNA and plays an important role in cutaneous malignant melanoma progression by suppressing TYR and PDIA3 expression.

  11. Four missense substitutions (p.Arg239Trp, p.Ser192Tyr, p.Ser44Arg and p.Arg77Gln) were identified in tyrosinase in the families with oculocutaneous albinism linkage, and another missense substitution (p.Gln272Lys) was identified in the family with OCA4 linkage

  12. LEF-1 and MITF regulate tyrosinase gene transcription in vitro via binding to its promoter.

  13. Data show that mutant microphthalmia-associated transcription factor (MITF) with loss of localization signals (NLS) has failed to transactivate the transcriptional activities of target gene tyrosinase (TYR), which can cause Waardenburg syndrome.

  14. The tyrosinase gene was examined in 23 unrelated patients with autosomal recessive ocular albinism or nonsyndromic oculocutaneous albinism. TYR gene mutations were identi fi ed in 14 (app. 60%) albinism patients.

  15. The two mutations (c.1114delG in the TYR gene and c.1426A>G in the OCA2 gene) may be responsible for partial clinical manifestations of Oculocutaneous albinism.

  16. Molecular analysis identified two compound heterozygous TYR mutations known to cause OCAIA and cosegregate with oculocutaneous albinism. In addition, we identified a novel heterozygous PAX6 mutation confirming the atypical aniridia phenotype.

  17. Overall, our data strongly suggest that IRF4, MC1R and TYR genes likely have pleiotropic effects, a combination of pigmentation and oncogenic functions, resulting in an increased risk of actinic keratosis.

  18. Data indicate that tyrosinase is used as a reporter gene owing to its strong optical absorption and enzymatic amplification mechanism and melamin production.

  19. Identification of four novel TYR mutations in a Chinese Han population with Oculocutaneous albinism 1.

  20. 11/11 individuals with homozygous or compound heterozygous mutations in TYR, have no discernible pigmentation in hair, skin and eyes

Mouse (Murine) Tyrosinase  (TYR) Interaktionspartner

  1. This study demonstrates the utility of CRISPR-Cas9 system in generating domain-specific in-frame deletions and helps gain further insights into structure-function of Tyr gene.

  2. These results suggest that the tyrosinase-induced metabolism of rhodendrol causes melanocyte toxicity.

  3. Data indicate that both ephedrannins A and B were competitive inhibitors of mushroom tyrosinase.

  4. STAP-2 colocalized with tyrosinase in lysosomes and protected tyrosinase from protein degradation in B16F10 melanoma cells.

  5. Docosahexaenoic acid inhibits melanogenesis in B16F10 cells in vitro through increased tyrosinase degradation.

  6. Studied upregulation by Kaliziri extract of tyrosinase, TRP-1, TRP-2 and MITF expression in murine B16 melanoma cells.

  7. The albino mutation of tyrosinase alters ocular angiogenic responsiveness.

  8. Tyrosinase is mutated in the albino dorsal lateral geniculate nucleus, arising from retinal ganglion cell misspecification together with potential perturbations of early activity patterns in the albino retina.

  9. activated by ascorbic acid in B16 melanoma via p38 MAPK signaling and upregulation of melanogenic regulatory factors

  10. Effect of zibuganshenfang on the expression and activity of tyrosinase on B16 cells

  11. the schisis phenotype caused by the Rs1 mutation is rescued by a Tyr mutation in the C57BL/6J genetic background, strongly suggesting that Tyr is the Mor1 gene.

  12. Data suggest that accumulation of tyrosinase in the endoplasmic reticulum of melanocytes leads to ER stress and activation of the unfolded protein response.

  13. Data show that interfering with p38 MAPK expression stimulates melanogenesis and tyrosinase family protein expression.

  14. role of P protein and tyrosinase in oculocutaneous albinism

  15. processing is controlled by pink-eyed dilution protein

  16. identified the tyrosinase gene (Tyr) as a modifier of the drainage structure phenotype in developmental glaucoma

  17. Tyrosinase maturation and oligomerization in the endoplasmic reticulum require a melanocyte-specific factor

  18. investigation of the boundary activity of locus control regions in transgenic animals and cells

  19. tyrosinase has a role in fatty acid regulation of pigmentation

  20. Interactions between N-linked glycans and lectin chaperones help to minimize tyrosinase aggregation and also target non-native substrates for retro-translocation and subsequent degradation

Guinea Pig Tyrosinase  (TYR) Interaktionspartner

  1. the missense mutation (c.710A>G; p.Asp237Gly) in the TYR gene is associated with the albino phenotype in guinea pig

Rabbit Tyrosinase  (TYR) Interaktionspartner

  1. the 3' UTR of the rabbit Tyr gene was deleted by a dual sgRNA directed CRISPR/Cas9 system which resulted in gray coat color and reduced melanin in hair follicles and irises was found in the mutated rabbit.

  2. we identified some genes that are related to fur formation, including Tyrosinase-related protein 1 (TYRP1) and Tyrosinase (TYR), as well as genes with unknown functions.

Tyrosinase  (TYR) Protein Überblick

Protein Überblick

The enzyme encoded by this gene catalyzes the first 2 steps, and at least 1 subsequent step, in the conversion of tyrosine to melanin. The enzyme has both tyrosine hydroxylase and dopa oxidase catalytic activities, and requires copper for function. Mutations in this gene result in oculocutaneous albinism, and nonpathologic polymorphisms result in skin pigmentation variation. The human genome contains a pseudogene similar to the 3' half of this gene.

Genbezeichner und Symbole assoziert mit Tyrosinase  Proteine (TYR)

  • tyrosinase (tyr)
  • TYRosinase (tyr-5)
  • tyrosinase S homeolog (tyr.S)
  • tyrosinase (TYR)
  • tyrosinase (Celal_3121)
  • tyrosinase (Halhy_4121)
  • tyrosinase (Mesop_2736)
  • tyrosinase (LOC100136546)
  • tyrosinase (Tyr)
  • albino Protein
  • C Protein
  • CMM8 Protein
  • LOC100136546 Protein
  • OCA1A Protein
  • OCAIA Protein
  • sandy Protein
  • SHEP3 Protein
  • skc35 Protein
  • tyr Protein
  • TYRO Protein
  • zgc:109705 Protein

Bezeichner auf Proteinebene für Tyrosinase  Proteine (TYR)

oca1 , sdy , tyra , hypothetical protein , tyrosinase (oculocutaneous albinism IA) , tyrosinase , monophenol monooxygenase , tyrosinase-like , LB24-AB , SK29-AB , oculocutaneous albinism IA , tumor rejection antigen AB , albino locus protein

30207 Danio rerio
189907 Caenorhabditis elegans
398715 Xenopus laevis
451473 Pan troglodytes
705792 Macaca mulatta
10145547 Cellulophaga algicola DSM 14237
10588308 Haliscomenobacter hydrossis DSM 1100
10826573 Mesorhizobium opportunistum WSM2075
100049427 Oryzias latipes
100125152 Xenopus (Silurana) tropicalis
100135825 Oncorhynchus mykiss
100136546 Salmo salar
100453479 Pongo abelii
100594055 Nomascus leucogenys
7299 Homo sapiens
22173 Mus musculus
308800 Rattus norvegicus
100713552 Cavia porcellus
403405 Canis lupus familiaris
751100 Felis catus
100008753 Oryctolagus cuniculus
407745 Sus scrofa
280951 Bos taurus
373971 Gallus gallus
780502 Ovis aries
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