Tumor Protein P63 Proteine (TP63)

TP63 encodes a member of the p53 family of transcription factors. Zusätzlich bieten wir Ihnen p63 Antikörper (77) und p63 Kits (31) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
TP63 8626 Q9H3D4
TP63 246334 Q9JJP6
TP63 22061 O88898
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
Baculovirus infected Insect Cells Human GST tag,His tag 100 μg Anmelden zum Anzeigen 20 bis 21 Tage
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
Escherichia coli (E. coli) Human Unkonjugiert   50 μg Anmelden zum Anzeigen 2 bis 3 Tage

TP63 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
, ,
Rat (Rattus)

Mouse (Murine)

Am meisten referenzierte p63 Proteine

  1. Human p63 Protein expressed in Wheat germ - ABIN1323400 : Huang, Jeong, Okamura, Sook-Kim, Zhu, Guerrero-Preston, Ratovitski: Global tumor protein p53/p63 interactome: making a case for cisplatin chemoresistance. in Cell cycle (Georgetown, Tex.) 2012 (PubMed)

Weitere Proteine zu Tumor Protein P63 (TP63) Interaktionspartnern

Human Tumor Protein P63 (TP63) Interaktionspartner

  1. miR (zeige MLXIP Proteine)-124 regulates p63 (zeige RPE65 Proteine) via iASPP (zeige PPP1R13L Proteine), while p63 (zeige RPE65 Proteine) targets miR (zeige MLXIP Proteine)-155 via the modulation of STAT1 (zeige STAT1 Proteine) expression in colorectal cancer.

  2. The number of p63 (zeige RPE65 Proteine)(+) cells is significantly higher in both hyperplastic (1.53-fold, P < 0.0001) and squamous metaplastic (2.02-fold, P < 0.0001) epithelium from nasal polyps than from healthy controls

  3. In p53 (zeige TP53 Proteine)-deficient breast cancers, compensatory mechanism of NFkB repression by p63 (zeige RPE65 Proteine) and p73 (zeige TP73 Proteine) during genotoxic stress could lead to complex effects that would influence all aspects of tumor progression.

  4. findings illustrate that DeltaNp63alpha can inhibit the levels of LIF (zeige LIF Proteine) mRNA by direct transcription regulation and decrease LIF (zeige LIF Proteine) mRNA stability by suppressing the expression of Lnc-LIF (zeige LIF Proteine)-AS. An inverse interaction of LIF (zeige LIF Proteine) and DeltaNp63alpha expression was as well validated in clinical samples of cervical cancer, and high level of LIF (zeige LIF Proteine) in cervical cancers was related with poor patient survival.

  5. Negative staining for CK5 (zeige KRT5 Proteine)/6 and p63 (zeige RPE65 Proteine) can be helpful to distinguish Well-differentiated neuroendocrine tumors (WDNETs) from cutaneous adnexal neoplasms. It is important to consider WDNETs in the differential diagnosis of cutaneous adnexal neoplasms as low-grade tumors may be the first sign of aggressive metastatic disease

  6. EGFR (zeige EGFR Proteine) pathway gene expression analysis indicated that DeltaNp63 alters EGFR (zeige EGFR Proteine)-regulated genes involved in cell adhesion, migration, and angiogenesis. Addition of EGF (zeige EGF Proteine) or neutralizing EGFR (zeige EGFR Proteine) antibodies demonstrated that EGFR (zeige EGFR Proteine) activation is responsible for DeltaNp63-mediated loss of cellular adhesion

  7. SNHG1 might play an oncogenic role in SCC through ZEB1 signaling pathway by inhibiting TAp63.

  8. This review discusses the evidence of DeltaNp63alpha as a master regulator of epithelial-mesenchymal transition (EMT (zeige ITK Proteine)) components and miRNA, highlighting the need for a deeper understanding of its role in EMT (zeige ITK Proteine).[review]

  9. miR (zeige MLXIP Proteine)-223-5p overexpression is a putative pathological mechanism of tumor invasion and a promising therapeutic target; both miR (zeige MLXIP Proteine)-223-5p and p63 (zeige RPE65 Proteine) may be prognostic factors in vulvar cancer

  10. miR (zeige MLXIP Proteine)-133b plays an important role in the anti-tumor effects of TAp63 in colorectal cancer.

Horse (Equine) Tumor Protein P63 (TP63) Interaktionspartner

  1. p63 expression was significantly lower in the chronic laminitic hoof than in that of control horses

Zebrafish Tumor Protein P63 (TP63) Interaktionspartner

  1. they unravel essential roles of TAp63 and p53 (zeige TP53 Proteine) to promote both keratinocyte proliferation and their terminal differentiation by promoting Notch (zeige NOTCH1 Proteine) signalling and caspase 3 (zeige CASP3 Proteine) activity.

  2. the p63 transcription factor is upregulated to initiate this apoptotic pathway and directly activates puma (zeige BBC3 Proteine) transcription in response to ER stress.

  3. Early zebrafish embryos express a dominant-negative form of p63 (DeltaNp63), which accumulates in the nucleus just as epidermal growth begins. (p63)

  4. DeltaNp63 expression blocks neural development and promotes nonneural development, even in the absence of Bmp signaling. (DeltaNp63)

  5. rps19 (zeige RPS19 Proteine)-deficient phenotype is mediated by dysregulation of deltaNp63 and p53 (zeige TP53 Proteine) and results in hematopoietic and developmental abnormalities resembling Diamond-Blackfan anemia

Mouse (Murine) Tumor Protein P63 (TP63) Interaktionspartner

  1. Overexpression of DeltaNp63 in transgenic mouse epidermis results in a severe skin phenotype that shares many of the key clinical, histological and molecular features associated with Atopic dermatitis and IL-31 (zeige IL31 Proteine) and IL-33 (zeige IL33 Proteine) are key players in the signaling pathways.

  2. cells expressing both p63 (zeige CKAP4 Proteine) and p73 (zeige ARHGAP24 Proteine) exist in mouse epidermis and hair follicle and that hetero-tetramer complexes can be detected by immunoprecipitation in differentiating keratinocytes.

  3. Data suggest that this the selective targeting of genes by tumor suppressor protein (zeige TP53 Proteine) p63 (p63 (zeige CKAP4 Proteine)) correlates with subtle, but measurable transcriptional differences in mouse and human keratinocytes that converges on major metabolic processes, which often exhibit species-specific trends.

  4. p63alpha protein up-regulates heat shock protein 70 (zeige HSP70 Proteine) expression via E2F1 transcription factor (zeige E2F1 Proteine) 1 (zeige HNF1A Proteine), promoting Wasf3/Wave3 (zeige WASF3 Proteine)/MMP9 (zeige MMP9 Proteine) signaling and bladder cancer invasion

  5. these results therefore highlight an unanticipated role for p53 (zeige TP53 Proteine) family proteins in a regulatory network that integrates essential Wnt (zeige WNT2 Proteine)-Tcf (zeige HNF4A Proteine) and nodal-Smad (zeige SMAD1 Proteine) inputs.

  6. the double mutant spermatocytes apoptosed at late pachynema because of sex body deficiency; thus p53 (zeige TP53 Proteine) and TAp63 are dispensable for arrest caused by sex body defects. These data affirm that recombination-dependent and sex body-deficient arrests occur via genetically separable mechanisms.

  7. TGFb3 (zeige TGFB3 Proteine)-induced down-regulation of p63 (zeige CKAP4 Proteine) in the medial edge epithelia of the palatal shelves is a pre-requisite for palatal fusion by facilitating periderm migration from, and reducing the proliferative potential of, the midline epithelial seam thereby preventing cleft palate.

  8. miR-20a-5p contributes to hepatic glycogen synthesis through targeting p63 to regulate p53 and PTEN expression.

  9. Taken together, these data show that p63 (zeige CKAP4 Proteine) regulates the self-renewal and differentiation of oesophageal stem cells in humans and mice.

  10. IL-6 (zeige IL6 Proteine)/P-STAT3 (zeige STAT3 Proteine) activation influences p63 (zeige CKAP4 Proteine) isoform expression in healing wounds, which may contribute to wound-induced hair follicle neogenesis.

Xenopus laevis Tumor Protein P63 (TP63) Interaktionspartner

  1. Data indicate that pluripotency genes sox2, p63 and oct60 are upregulated early during the process of lens regeneration.

  2. The results suggest that DeltaNp63 is an essential gene in early epidermal specification under the control of BMP4 (zeige BMP4 Proteine).

  3. The role of p63 as a negative Wnt (zeige WNT2 Proteine)-regulator thus matches with the frequently observed downregulation of p63 during tumor progression, when cancer cells adopt a more mesenchymal, invasive phenotype.

p63 (TP63) Protein Überblick

Protein Überblick

This gene encodes a member of the p53 family of transcription factors. An animal model, p63 -/- mice, has been useful in defining the role this protein plays in the development and maintenance of stratified epithelial tissues. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3)\; split-hand/foot malformation 4 (SHFM4)\; ankyloblepharon-ectodermal defects-cleft lip/palate\; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth)\; limb-mammary syndrome\; Rap-Hodgkin syndrome (RHS)\; and orofacial cleft 8. Both alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different proteins. Many transcripts encoding different proteins have been reported but the biological validity and the full-length nature of these variants have not been determined.

Genbezeichner und Symbole assoziert mit Tumor Protein P63 Proteine (TP63)

  • tumor protein p63 (TP63)
  • tumor protein p63 (tp63)
  • tumor protein p63 (Tp63)
  • transformation related protein 63 (Trp63)
  • tumor protein p63 L homeolog (tp63.L)
  • AI462811 Protein
  • AIS Protein
  • B(p51A) Protein
  • B(p51B) Protein
  • DNp63 Protein
  • EEC3 Protein
  • id:ibd3516 Protein
  • ket Protein
  • LMS Protein
  • NBP Protein
  • np63 Protein
  • OFC8 Protein
  • p40 Protein
  • p51 Protein
  • P51/P63 Protein
  • p53CP Protein
  • P63 Protein
  • p73H Protein
  • P73l Protein
  • RHS Protein
  • SHFM4 Protein
  • TP53CP Protein
  • TP53L Protein
  • Tp63 Protein
  • Tp73l Protein
  • tp73l-A Protein
  • Trp53rp1 Protein
  • trp63 Protein
  • wu:fc89f04 Protein
  • wu:fk85h07 Protein
  • wu:fk88b02 Protein
  • Xp63 Protein

Bezeichner auf Proteinebene für Tumor Protein P63 Proteine (TP63)

CUSP , amplified in squamous cell carcinoma , chronic ulcerative stomatitis protein , keratinocyte transcription factor KET , transformation-related protein 63 , tumor protein 63 , tumor protein p53-competing protein , tumor protein p63 deltaN isoform delta , tumor protein p63 , delta-Np63 , fc89f04 , transformation related protein 63 , tumor protein 63 kDa , tumor protein 63-like

8626 Homo sapiens
100059752 Equus caballus
100170632 Oryzias latipes
260407 Danio rerio
703997 Macaca mulatta
615335 Bos taurus
246334 Rattus norvegicus
374269 Gallus gallus
460930 Pan troglodytes
488125 Canis lupus familiaris
100227936 Taeniopygia guttata
100386953 Callithrix jacchus
100444448 Pongo abelii
100606847 Nomascus leucogenys
22061 Mus musculus
373640 Xenopus laevis
100625258 Sus scrofa
100355881 Oryctolagus cuniculus
100732143 Cavia porcellus
101108874 Ovis aries
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