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Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Zusätzlich bieten wir Ihnen und viele weitere Produktgruppen zu diesem Protein an.
These data indicate that endogenous mMCP6 has scar-suppressing properties after spinal cord injury via indirect cleavage of axon growth-inhibitory scar components and alteration of the gene expression profile of these factors.
Inflammatory Th2 responses can develop independently of MCP-6, whereas MCP-6 plays a key role in the development of airway hyperresponsiveness.
Tryptase (zeige TPSAB1 Antikörper)-beta was capable of inducing pelvic pain and was increased in experimental autoimmune prostatitis.
mast cell tryptase, a serglycin proteoglycan (zeige SRGN Antikörper)-dependent secretory granule protease, has a role in proteolytic histone modification
Trypase can promote atherosclerotic plaque haemorrhage by promoting angiogenesis and regulating the balance of PAI-1 (zeige SERPINE1 Antikörper) and tPA (zeige PLAT Antikörper).
This study demonstrates for the first time that an mast cell-restricted tetramer-forming tryptase (zeige TPSAB1 Antikörper) has a prominent adverse role in experimental chronic obstructive pulmonary disease
this study indicates that mast cells may be a source of TGF-beta (zeige TGFB1 Antikörper) production after cigarette smoke exposure and that in turn TGF-beta (zeige TGFB1 Antikörper) may change the tryptase (zeige TPSAB1 Antikörper) expression in mast cells.
MCP6 actively depletes the local environment of IL-6 (zeige IL6 Antikörper) to maintain tolerance in mice.
MCP-6 (but not MCP-7 (zeige TPSAB1 Antikörper)) is an essential mast cell-restricted mediator in chemically induced colitis and acts upstream of many of the factors implicated in inflammatory bowel disease.
mast cell mMCP-4, -5, and -6 (chymase (zeige CMA1 Antikörper) and tryptase (zeige TPSAB1 Antikörper)) participate in the acute inflammation and remodeling process of viral myocarditis.
These observations indicate that betaII-tryptase (zeige TPSAB1 Antikörper) activity is post-translationally regulated by an allosteric disulfide bond.
Results indicate a key role for heparin in the activation of human betaI- and beta2-tryptase (zeige TPSAB1 Antikörper).
The disease severity and plasma tryptase (zeige TPSAB1 Antikörper) levels were not affected by the number of alpha or beta tryptase (zeige TPSAB1 Antikörper) alleles in mastocytosis patients.
Strong linkage of TPSAB1 (zeige TPSAB1 Antikörper) and TPSB2 and pairing of deficiency alleles with functional alleles in observed haplotypes protect human subjects from "knockout" genomes and indeed from inheritance of fewer than 2 active alleles.
Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, beta II and beta III. Beta tryptases appear to be the main isoenzymes expressed in mast cells, whereas in basophils, alpha-tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders.
mast cell protease 6
, tryptase beta-2
, mast cell tryptase beta II
, mast cell tryptase beta III