Troponin I Type 3 (Cardiac) Proteine (TNNI3)

Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. Zusätzlich bieten wir Ihnen Troponin I Type 3 (Cardiac) Antikörper (893) und Troponin I Type 3 (Cardiac) Kits (130) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
TNNI3 7137 P19429
TNNI3 21954 P48787
TNNI3 29248 P23693
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Top Troponin I Type 3 (Cardiac) Proteine auf antikoerper-online.de

Showing 10 out of 38 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$5,465.26
Details
Escherichia coli (E. coli) Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$5,465.26
Details
Escherichia coli (E. coli) Human GST tag Troponin I Type 3 (Cardiac) (TNNI3) (AA 1-146), (partial) protein (GST tag) 1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$1,842.50
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Insect cells (Sf9) Human DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
$504.90
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
$814.00
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Escherichia coli (E. coli) Human His tag 50 μg Anmelden zum Anzeigen 11 Days
$313.50
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Baculovirus infected Insect Cells Human His tag 50 μg Anmelden zum Anzeigen 2 bis 3 Tage
$1,353.00
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Wheat germ Human GST tag 2 μg Anmelden zum Anzeigen 11 bis 12 Tage
$338.33
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Escherichia coli (E. coli) Maus His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$640.00
Details
Escherichia coli (E. coli) Human His tag   10 μg Anmelden zum Anzeigen 15 bis 16 Tage
$325.00
Details

TNNI3 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , , , ,
, , , ,
Mouse (Murine)

Rat (Rattus) ,

Weitere Proteine zu Troponin I Type 3 (Cardiac) (TNNI3) Interaktionspartnern

Human Troponin I Type 3 (Cardiac) (TNNI3) Interaktionspartner

  1. Studies indicate that in patients with end-stage renal disease (ESRD), elevation of cardiac-specific troponin T (cTnT) was more frequent than elevation of troponin I (cTnI) [Review].

  2. the frequency of h-FABP (zeige FABP3 Proteine) positivity among acute myocardial infarction patients was higher than that of hs-TnI (zeige TNNI2 Proteine), which would have missed six of them; however, hs-TnI (zeige TNNI2 Proteine) area under curve was superior to that of h-FABP (zeige FABP3 Proteine).

  3. Reversible Covalent Reaction of Levosimendan with Cardiac Troponin C (zeige TNNC1 Proteine) in Vitro and in Situ.

  4. Mutations in genes encoding cardiac troponin I (TNNI3) and cardiac troponin T (TNNT2 (zeige TNNT2 Proteine)) caused altered troponin protein stoichiometry in patients with dilated cardiomyopathy. TNNI3p.98trunc resulted in haploinsufficiency, increased Ca(2 (zeige CA2 Proteine)+) -sensitivity and reduced length-dependent activation. TNNT2p.K217del caused increased passive tension.

  5. The QT interval has a strong positive linear correlation with cardiac troponin-I levels in Non-ST-elevation myocardial infarction.

  6. Apelin (zeige APLN Proteine)-12 influences troponin I levels in the acute phase of STEMI, whereas during the non-acute phase, low apelin (zeige APLN Proteine) levels were associated with a high rate of MACE.

  7. In clinical stable patients without known cardiovascular disease, a thorough chest-pain history in combination with hs-TnI (zeige TNNI2 Proteine) testing can identify a significant low-risk group.

  8. Study showed that in patients who underwent liver transplantation elevation of preoperative high-sensitivity cardiac troponin I level was associated with 1-year mortality and 30-day mortality.

  9. Serial measurement of troponin I revealed a persistent elevation in patients with diabetes mellitus type 2.

  10. Plasma troponin C1 (cTnI) is biomarker of choice for diagnosing acute myocardial infarction (AMI (zeige CFD Proteine)) because of its high specificity as biomarker for damage to myocardial tissue. Data suggest the "best cut-off" for plasma cTnI is 0.014 micrograms/L in AMI (zeige CFD Proteine). These studies were conducted in emergency department of a university hospital in Italy using point-of-care testing in patients presenting with chest pain, ages 18-101.

Mouse (Murine) Troponin I Type 3 (Cardiac) (TNNI3) Interaktionspartner

  1. Pim-1 is a novel kinase that phosphorylates cTnI primarily at Ser23/24 and Ser150 in cardiomyocytes, which in turn may modulate myofilament function under a variety of physiological and pathophysiological conditions.

  2. Hyperphosphorylation of this serine199 in cTnI C terminus impacts heart function by depressing diastolic function at baseline and limiting systolic reserve under physiological stresses. Paradoxically, it preserves heart function after ischemia/reperfusion injury, potentially by decreasing proteolysis of cTnI.

  3. The contributions of cardiac myosin binding protein C and troponin I phosphorylation to beta-adrenergic enhancement of in vivo cardiac function

  4. The difference in myosin regulatory light chain phosphorylation between the ventricles of R21C(+/+) in cardiac troponin I mice likely contributes to observed differences in contractile force and the lower tension monitored in the LV of HCM mice

  5. troponin I phosphorylation specifically alters the Ca(2 (zeige CA2 Proteine)+) sensitivity of isometric tension and the time course of relaxation in cardiac muscle myofibrils

  6. Combined troponin I Ser (zeige SIGLEC1 Proteine)-150 and Ser (zeige SIGLEC1 Proteine)-23/24 phosphorylation sustains thin filament Ca(2 (zeige CA2 Proteine)+) sensitivity playing an adaptive role to preserve contraction during acidic ischemia.

  7. these results indicate that the inability to enhance myofilament relaxation through cTnI phosphorylation predisposes the heart to abnormal diastolic function, reduced accessibility of cardiac reserves, dysautonomia, and hypertrophy.

  8. Dominant negative TnI-TnT interface mutation decreases the binding affinity of cTnI for TnT, causes early ventricular remodeling, and blunts the beta-adrenergic response of cardiac myocytes.

  9. R193H and R205H mutation increase the binding affinity of Troponin I for Troponin T and Troponin C.

  10. Conclude that dilated cardiomyopathy-causing mutations in thin filament proteins abolish the relationship between myofilament Ca(2+) sensitivity and troponin I phosphorylation by PKA.

Cow (Bovine) Troponin I Type 3 (Cardiac) (TNNI3) Interaktionspartner

  1. An Ala8Val mutation enhances the effect of cardiac troponin I pseudophosphorylation on the rate of dissociation of calcium from reconstituted thin filaments.

  2. Serum cardiac troponin I cannot be used to distinguish cattle with pericarditis from cattle with other primary cardiac diseases or noncardiac, intrathoracic disorders.

Horse (Equine) Troponin I Type 3 (Cardiac) (TNNI3) Interaktionspartner

  1. Cardiac ANP was increased in horses with mitral regurgitation (MR) and cardiac troponin levels were low in healthy and MR affected horses.

Pig (Porcine) Troponin I Type 3 (Cardiac) (TNNI3) Interaktionspartner

  1. We show that the phosphorylation of cTnI and alphaTm vary in the different chambers of the heart, whereas the phosphorylation of MLC2 and cTnT does not.

  2. hFABP (zeige FABP3 Proteine) rises faster and correlates better with infarct size and no-reflow than hsTnI in myocardial infarction + reperfusion when measured early after reperfusion.

  3. analysis of expression profiling of porcine troponin I family in three different types of muscles during development

Rainbow Trout (Oncorhynchus mykiss) Troponin I Type 3 (Cardiac) (TNNI3) Interaktionspartner

  1. By replacing rat cardiac troponin I (cTnI) in a mammalian cTn complex with trout cTnI it was demonstrated that this protein increases the Ca2+ affinity and reduces the influence of PKA phosphorylation on the Ca2+ affinity of the cTn complex.

Troponin I Type 3 (Cardiac) (TNNI3) Protein Überblick

Protein Überblick

Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit\; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM).

Genbezeichner und Symbole assoziert mit TNNI3

  • troponin I3, cardiac type (TNNI3)
  • troponin I, cardiac 3 (Tnni3)
  • troponin I type 3 (cardiac) (TNNI3)
  • troponin I3, cardiac type S homeolog (tnni3.S)
  • troponin I3, cardiac type L homeolog (tnni3.L)
  • troponin I3, cardiac type (tnni3)
  • cardiac troponin I (LOC100462680)
  • troponin I3, cardiac type (Tnni3)
  • c-troponin Protein
  • CMD1FF Protein
  • CMD2A Protein
  • cmh7 Protein
  • cTNI Protein
  • ctnIc Protein
  • cTNT Protein
  • RCM1 Protein
  • Tn1 Protein
  • TnI Protein
  • TnIc Protein
  • tnnc1 Protein
  • TNNI3 Protein
  • XTnIc Protein

Bezeichner auf Proteinebene für TNNI3

troponin I, cardiac muscle , cardiac troponin I , troponin IC , troponin I type 3 (cardiac) , cardiac tropin T , troponin I, cardiac , troponin 1, type 3

GENE ID SPEZIES
7137 Homo sapiens
21954 Mus musculus
396428 Gallus gallus
397803 Xenopus laevis
403566 Canis lupus familiaris
494826 Xenopus laevis
496889 Xenopus (Silurana) tropicalis
511094 Bos taurus
100034065 Equus caballus
100049696 Sus scrofa
100462680 Oncorhynchus mykiss
698470 Macaca mulatta
29248 Rattus norvegicus
493744 Felis catus
101121961 Ovis aries
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