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E3 ubiquitin-protein ligase that mediates 'Lys-63'- linked polyubiquitination of TMEM173/STING, thereby playing a key role in innate immunity. Zusätzlich bieten wir Ihnen TRIM56 Antikörper (34) und viele weitere Produktgruppen zu diesem Protein an.
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SopA inhibits TRIM56 E3 ligase activity by occluding the E2-interacting surface of TRIM56.
TRIM56 E3 ligase-induced monoubiquitination of cGAS is important for cytosolic DNA sensing and IFNalphabeta production to induce anti-DNA viral immunity.
TRIM56 may act as a tumor suppressor in multiple myeloma through activation of TLR3/TRIF signaling pathway.
TRIM56 is the ubiquitin ligase that is degrading vimentin in ovarian cancer cells, regulation cell migration and neoplasm invasiveness.
The C-Terminal Tail of TRIM56 Dictates Antiviral Restriction of Influenza A and B Viruses by Impeding Viral RNA Synthesis
Altogether, TRIM56 is a versatile antiviral host factor that confers resistance to yellow fever virus, dengue virus serotype 2, and human coronavirus OC43 through overlapping and distinct molecular determinants
TRIM56 is an essential component of the TLR3 antiviral signaling pathway and reveal a novel role for TRIM56 in innate antiviral immunity.
TRIM56 is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells.
These data demonstrate that TRIM56 is a novel antiviral host factor that restricts pestivirus infection.
TRIM56 is an interferon-inducible E3 ubiquitin ligase that modulates STING to confer double-stranded DNA-mediated innate immune responses.
E3 ubiquitin-protein ligase that mediates 'Lys-63'- linked polyubiquitination of TMEM173/STING, thereby playing a key role in innate immunity. TMEM173/STING 'Lys-63'-linked ubiquitination activates the production of type I interferon IFN- beta following detection of pathogen- and host-derived double- stranded DNA.
tripartite motif-containing 56
, tripartite motif-containing protein 56-like
, tripartite motif containing 56
, E3 ubiquitin-protein ligase TRIM56
, RING finger protein 109
, tripartite motif-containing protein 56