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Trans-acting factor that regulates gene expression of interleukin 2 receptor alpha chain.
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Human Polyclonal Trim30 Primary Antibody für ELISA, ICC - ABIN4362468
Tyzack, Hall, Sibley, Cymes, Forostyak, Carlino, Meyer, Schiavo, Zhang, Gibbons, Newcombe, Patani, Lakatos: A neuroprotective astrocyte state is induced by neuronal signal EphB1 but fails in ALS models. in Nature communications 1970
Data indicated that Trim30 and Ucp3 (zeige UCP3 Antikörper) play pivotal roles in energy balance and glucose homeostasis and might be used as genetic markers to represent the stage of obesity during the early and late stages of adipose tissue development, respectively.
These results indicate a distinct requirement for TRIM30 in modulation of NF-kappaB activation and cell proliferation induced by TCR stimulation.
Lymphotoxin-beta receptor (zeige LTBR Antikörper) signalling regulates cytokine expression via TRIM30alpha in a TRAF3 (zeige TRAF3 Antikörper)-dependent manner.
TRIM30alpha is a target gene of LTbetaR signaling in bone marrow-derived macrophages LTbetaR-induced TRIM30alpha expression inhibits the production of proinflammatory cytokines & mediators upon TLR4 (zeige TLR4 Antikörper) & TLR9 (zeige TLR9 Antikörper) restimulation.
TRIM30 is a negative regulator of NLRP3 (zeige NLRP3 Antikörper) inflammasome activation and provide insights into the role of TRIM30 in maintaining inflammatory responses.
Tripartite-motif protein TRIM30alpha interacts with the TAB2 (zeige TAB2 Antikörper)-TAB3 (zeige TAB3 Antikörper)-TAK1 (zeige NR2C2 Antikörper) adaptor-kinase complex involved in the activation of transcription factor NF-kappaB (zeige NFKB1 Antikörper).
Trans-acting factor that regulates gene expression of interleukin 2 receptor alpha chain. May affect IL2R-alpha expression through cis-acting negative regulatory elements or through competition with proteins that bind to enhancer or activator sequences. Negatively regulates Toll-like receptor (TLR)-mediated activation of NFKB by promoting degradation of TAB2 and TAB3 and preventing TRAF6 autoubiquitination. Negatively regulates production of reactive oxygen species (ROS) which inhibits activation of the NLRP3 inflammasome complex. This, in turn, regulates activation of CASP1 and subsequent cleavage of IL1B and IL18. No activity detected against a range of retroviruses including a number of lentiviruses, gammaretroviruses and betaretroviruses.
down regulatory protein of interleukin-2 receptor
, regulatory protein, T lymphocyte 1
, tripartite motif protein 30
, tripartite motif-containing 30
, tripartite motif-containing protein 30
, tripartite motif-containing protein 30A