Trefoil Factor 2 Proteine (TFF2)

Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. Zusätzlich bieten wir Ihnen Trefoil Factor 2 Antikörper (136) und Trefoil Factor 2 Kits (62) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
TFF2 7032 Q03403
TFF2 116592 Q09030
TFF2 21785  
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Showing 10 out of 38 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 bis 55 Tage
Human Cells Human His tag   50 μg Anmelden zum Anzeigen 4 Days
Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
Escherichia coli (E. coli) Maus His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
Escherichia coli (E. coli) Ratte His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
Escherichia coli (E. coli) Human Unkonjugiert   100 μg Anmelden zum Anzeigen 2 bis 3 Tage
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 11 Days
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
Human Cells Human His tag   10 μg Anmelden zum Anzeigen 15 bis 16 Tage

TFF2 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , , ,
, ,
Rat (Rattus)

Mouse (Murine) , ,

Weitere Proteine zu Trefoil Factor 2 (TFF2) Interaktionspartnern

Human Trefoil Factor 2 (TFF2) Interaktionspartner

  1. Serum concentrations of TFF1 and TFF3 but not TFF2 are higher in women with breast cancer than in women without breast cancer.

  2. results suggest that TFF1 and TFF3, but not TFF2, may have a role in breast tumor pathogenesis

  3. TFF2 is a promising immunohistochemical marker and its identification in uterine cervical secretion is a potentially useful diagnostic test for endocervical glandular lesions with gastric differentiation.

  4. The urine TFF1 and TFF3 levels significantly increased with the progression of chronic kidney disease stages, but not the urine TFF2 levels.

  5. Data show that trefoil factor 2 (TFF2( urine levels continuously decreased with disease progression, TFF2 serum concentrations progressively increased from the early to later chronic kidney disease (CKD) stages, indicating changes in renal function and offering the potential to examine the course of CKD.

  6. this work reveals that TFF2 has tumor-suppressor activity, which may, in part, be regulated by SMAD4.

  7. Data indicate that the antitumor activity of trefoil factor 2 (TFF2) is mediated by an interaction with the transcription factor Sp3 (Sp3) in gastric cancer cells.

  8. Data show the important functions of TFF2 in the gastric mucus barrier, mucus epithelia, immune system, central nervous system, and during fertilization. It has been shown to interact with the gastric mucin MUC6. [Review]

  9. These findings suggest that the rs184432 and rs225359 polymorphisms in TFF1 have protective effects for GC and contribute to the development of GC in Korean individuals.

  10. We reproducibly associate higher expression of the ligand-receptor axis of TFF2 and CXCR4 with BRAF V600E-mutant colon cancer

  11. protease-activated receptor 4 and Trefoil factor 2 are expressed in human colorectal cancer

  12. The structural features of the N-linked N,N'-di-N-acetyllactosediamine-inducing determinant on human TFF2 are discussed.

  13. Human TTF2 is a lectin that binds alpha-GlcNAc-capped mucin 6 g with antibiotic activity against Helicobacter pylori.

  14. Significantly higher levels of TFF2 were in patients with Multiple Organ Dysfunction Syndrome.

  15. There is an association between TFF2 and TFF3 polymorphisms and risk of atrophic gastritis and gastric cancer in Chinese people.

  16. Human gastric TFF2 peptide contains an N-linked fucosylated N,N'-diacetyllactosediamine (LacdiNAc) oligosaccharide

  17. this study indicated that Sp3 was a major regulator of TFF2 expression.

  18. Report TFF2 expression in normal/diseased pancreas and suggest role in tumor cell migration.

  19. Report a novel TFF2 splice variant (EX2TFF2) which correlates with longer overall survival time in cholangiocarcinoma.

  20. TFF2 messenger RNA expression is significantly increased in nasal mucosal brushings during asthma exacerbations in children.

Pig (Porcine) Trefoil Factor 2 (TFF2) Interaktionspartner

  1. Low intestinal TFF2 expression was measured at early maturation stages. Weaning, however, was associated with a distinct response of increased TFF2 expression, indicating an important role in enhancing mucosal integrity.

Mouse (Murine) Trefoil Factor 2 (TFF2) Interaktionspartner

  1. we show a previously unappreciated role for TFF2, produced by either hematopoietic or nonhematopoietic sources, as a pro-proliferative factor for lung epithelial cells under steady-state and infectious injury conditions.

  2. the Tg(Tff1-CreERT2;Tff2-rtTA;Tff3-Luc) strain can confer intermittent transgene expression to gastric epithelial cells that have undergone previous gene modification, and may be suitable to genetically model therapeutic intervention during development, tumorigenesis, and other genetically tractable diseases

  3. Splenic TFF2 is released by vagally modulated memory T cells to suppress expansion of myeloid-derived suppressor cells (MDSC) through CXCR4. TFF2 is important to the anti-inflammatory reflex arc and has an essential role in arresting MDSC proliferation.

  4. hnRNP A1 improves intestinal injury in anti-CD3 antibody-induced enteritis mice through the upregulation of TFF2, which regulates apoptosis and enhances epithelial restoration

  5. Overexpressing Tff2 in cultured cells reduced doubling time in vitro and rapidly increased xenograft tumor size in vivo

  6. Epithelial TFF2 is an important endogenous regulator of gut mucosal homeostasis that can modulate immune and epithelial compartments.

  7. The Tff2 gene is expressed in the hypothalamus and is regulated by food intake. Knockout mice are leaner and have reduced fat mass compared to wild-type.

  8. The increased expression of endogenous TFF2 in response to chronic allergic inflammation is insufficient to prevent the progression of airway inflammation and remodeling in a model of chronic allergic airways disease.

  9. TFF2 functions as a regulator of intestinal homeostasis that suppresses Toxoplasma gondii-driven type 1 inflammation.

  10. TFF2 (trefoil factor 2), an epithelial cell-derived repair molecule, is needed for the control of lung injury caused by the hookworm parasite Nippostrongylus brasiliensis and for type 2 immunity after infection.

  11. results suggest that during retinal cell death periods, requiring a tightly regulated balance between cell survival and cell death, TFF2 acts pro-proliferative and pro-apoptotic at least in developing mouse retinae cultured in vivo

  12. functional NHE2, but not NHE1, is essential for mouse gastric epithelial restitution and TFFs activate epithelial repair via NHE2

  13. Trefoil factor 2 plays a role in the pathogeneasis of airway remodeling in airway disease in the mouse model.

  14. TFF2 transcript-expressing cells are progenitors for mucus neck, parietal and zymogenic, but not for pit or enterochromaffin-like cell lineages in the oxyntic gastric mucosa

  15. TFF2 negatively regulates preneoplastic progression and subsequent tumor development in the stomach, a role that is subverted by promoter methylation during H pylori infection

  16. TFF2 plays a role in restitution after acute gastric epithelial injury, and the effect of exogenous trefoil peptides promote acute wound repair which does not require cyclooxygenase activity.

  17. TFF2 is an allergen-induced lung gene product differentially regulated by Th2 cytokines and STAT6

  18. Intestinal trefoil factor is involved in protection against and recovery from intestinal mucositis induced by radiation and chemotherapy.

  19. spasmolytic peptide expressing metaplasia represents a precursor lineage for the development of dysplasia in this animal model of gastric carcinogenesis.

  20. significant role for stromal TGF-beta signaling in mammary tissue homeostasis and mammary tumor progression via regulation of MSP signalin pathways

Trefoil Factor 2 (TFF2) Protein Überblick

Protein Überblick

Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. The encoded protein inhibits gastric acid secretion. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21.

Genbezeichner und Symbole assoziert mit Trefoil Factor 2 Proteine (TFF2)

  • trefoil factor 2 (TFF2)
  • trefoil factor 2 (Tff2)
  • trefoil factor 2 S homeolog (tff2.S)
  • trefoil factor 2 (spasmolytic protein 1) (Tff2)
  • mSP Protein
  • p4 Protein
  • p4-a Protein
  • PSP Protein
  • sml1 Protein
  • SP Protein
  • TFF2 Protein
  • xP4 Protein
  • xp4.1 Protein

Bezeichner auf Proteinebene für Trefoil Factor 2 Proteine (TFF2)

trefoil factor 2 , trefoil factor 2 (spasmolytic protein 1) , trefoil factor family peptide 2 , spasmolysin , spasmolytic polypeptide , spasmolytic protein 1 , pancreatic spasmolytic polypeptide , SP , spasmolytic peptide , spasmolytic peptide 1 , spasmolytic polypeptide 1 , P-domain peptide , TFF p4.1 , putative gastrointestinal growth factor xP4

418534 Gallus gallus
470096 Pan troglodytes
100170653 Felis catus
7032 Homo sapiens
397420 Sus scrofa
116592 Rattus norvegicus
403489 Canis lupus familiaris
616105 Bos taurus
101787738 Cavia porcellus
378510 Xenopus laevis
21785 Mus musculus
Ausgewählte Anbieter für Trefoil Factor 2 Proteine (TFF2)
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