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TRIP13 encodes a protein that interacts with thyroid hormone receptors, also known as hormone-dependent transcription factors. Zusätzlich bieten wir Ihnen TRIP13 Antikörper (83) und TRIP13 Proteine (8) und viele weitere Produktgruppen zu diesem Protein an.
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heightened TRIP13 expression appears to promote lung adenocarcinoma tumor progression.
TRIP13-p31(comet) intercepts and disassembles free mitotic checkpoint complex not bound to anaphase-promoting complex/cyclosome through mediating the local unfolding of the Mad2 C-terminal region.
Microarray analyses indicated that the biological function of TRIP13 in CLL is majorly cell apoptosis and cell proliferation associated. TRIP13 siRNA expressing cells exhibited a slower cell proliferation rate and underwent apoptosis compared with control cells.
TRIP13 ubiquitinates and degrades the checkpoint surveillance protein MAD2 via activating Akt (zeige AKT1 ELISA Kits) signaling pathway, leading to weakened checkpoint surveillance and consequent tumorigenic aneuploidy and drug resistance in MM.
These results identify an unexpected dependency on TRIP13 in cells overexpressing Mad2.
6 individuals with biallelic loss-of-function mutations in TRIP13 developed Wilms tumors. TRIP13-mutant patient cells have no detectable TRIP13 and have substantial impairment of the spindle assembly checkpoint (SAC (zeige ADCY10 ELISA Kits)), leading to a high rate of chromosome missegregation. Individuals with biallelic TRIP13 mutations have a high risk of embryonal tumors. These experiments show that their cells display severe SAC (zeige ADCY10 ELISA Kits) impairment.
Thes authors show that p31(comet) binding to the TRIP13 N-terminal domain positions the disordered MAD2 N-terminus for engagement by the TRIP13 "pore loops", which then unfold MAD2 in the presence of ATP.
These results establish a paradigm of the roles of p31(comet) and TRIP13 in both checkpoint activation and inactivation.
the oligomeric form of TRIP13 binds both p31(comet) and MCC
TRIP13 promotes error-prone non-homologous end joining and induces chemoresistance in head and neck cancer.
TRIP13 ubiquitinates and degrades the checkpoint surveillance protein MAD2 (zeige MXI1 ELISA Kits) via activating Akt (zeige AKT1 ELISA Kits) signaling pathway, leading to weakened checkpoint surveillance and consequent tumorigenic aneuploidy and drug resistance in MM.
TRIP13-deficient spermatocytes also progress to an H1t-positive stage if ATM (zeige ATM ELISA Kits) activity is attenuated by hypomorphic mutations in Mre11 (zeige MRE11A ELISA Kits) or Nbs1 (zeige NBN ELISA Kits) or by elimination of the ATM (zeige ATM ELISA Kits)-effector kinase CHK2 (zeige CHEK2 ELISA Kits)
TRIP13 is required for recombination and normal higher-order chromosome structure during meiosis.
HORMAD1 (zeige HORMAD1 ELISA Kits) and HORMAD2 (zeige HORMAD2 ELISA Kits) are depleted from synapsed chromosome axes with the help of TRIP13.
results demonstrate that in mice, the primary meiotic function of TRIP13 is in recombination itself
This gene encodes a protein that interacts with thyroid hormone receptors, also known as hormone-dependent transcription factors. The gene product interacts specifically with the ligand binding domain. This gene is one of several that may play a role in early-stage non-small cell lung cancer.
TR-interacting protein 13 homolog
, TRIP-13 homolog
, pachytene checkpoint protein 2 homolog
, thyroid hormone receptor interactor 13 homolog
, thyroid receptor-interacting protein 13 homolog
, Thyroid hormone receptor interactor 13 homolog
, Thyroid receptor-interacting protein 13 homolog
, thyroid hormone receptor interactor 13
, thyroid receptor-interacting protein 13-like
, HPV16 E1 protein binding protein
, HPV16 E1 protein-binding protein
, TR-interacting protein 13
, human papillomavirus type 16 E1 protein-binding protein
, thyroid receptor interacting protein 13
, thyroid receptor-interacting protein 13
, Pachytene checkpoint protein 2 homolog
, Thyroid receptor-interacting protein 13