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TRIP13 encodes a protein that interacts with thyroid hormone receptors, also known as hormone-dependent transcription factors. Zusätzlich bieten wir Ihnen TRIP13 Antikörper (82) und TRIP13 Proteine (8) und viele weitere Produktgruppen zu diesem Protein an.
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heightened TRIP13 expression appears to promote lung adenocarcinoma tumor progression.
TRIP13-p31(comet) intercepts and disassembles free mitotic checkpoint complex not bound to anaphase-promoting complex/cyclosome through mediating the local unfolding of the Mad2 C-terminal region.
Microarray analyses indicated that the biological function of TRIP13 in CLL is majorly cell apoptosis and cell proliferation associated. TRIP13 siRNA expressing cells exhibited a slower cell proliferation rate and underwent apoptosis compared with control cells.
TRIP13 ubiquitinates and degrades the checkpoint surveillance protein MAD2 via activating Akt signaling pathway, leading to weakened checkpoint surveillance and consequent tumorigenic aneuploidy and drug resistance in MM.
These results identify an unexpected dependency on TRIP13 in cells overexpressing Mad2.
6 individuals with biallelic loss-of-function mutations in TRIP13 developed Wilms tumors. TRIP13-mutant patient cells have no detectable TRIP13 and have substantial impairment of the spindle assembly checkpoint (SAC), leading to a high rate of chromosome missegregation. Individuals with biallelic TRIP13 mutations have a high risk of embryonal tumors. These experiments show that their cells display severe SAC impairment.
Thes authors show that p31(comet) binding to the TRIP13 N-terminal domain positions the disordered MAD2 N-terminus for engagement by the TRIP13 "pore loops", which then unfold MAD2 in the presence of ATP.
These results establish a paradigm of the roles of p31(comet) and TRIP13 in both checkpoint activation and inactivation.
the oligomeric form of TRIP13 binds both p31(comet) and MCC
TRIP13 promotes error-prone non-homologous end joining and induces chemoresistance in head and neck cancer.
suggest that premature mitotic checkpoint silencing triggered by TRIP13 overexpression may promote cancer development
propose that TRIP13 plays centrally important roles in the sequence of events leading to MCC disassembly and checkpoint inactivation
In all, these studies suggest that insufficient TRIP13 increased the susceptibility of damaged tubular epithelial cells to progress towards apoptotic cell death.
TRIP13-deficient spermatocytes also progress to an H1t-positive stage if ATM activity is attenuated by hypomorphic mutations in Mre11 or Nbs1 or by elimination of the ATM-effector kinase CHK2
TRIP13 is required for recombination and normal higher-order chromosome structure during meiosis.
HORMAD1 and HORMAD2 are depleted from synapsed chromosome axes with the help of TRIP13.
results demonstrate that in mice, the primary meiotic function of TRIP13 is in recombination itself
This gene encodes a protein that interacts with thyroid hormone receptors, also known as hormone-dependent transcription factors. The gene product interacts specifically with the ligand binding domain. This gene is one of several that may play a role in early-stage non-small cell lung cancer.
TR-interacting protein 13 homolog
, TRIP-13 homolog
, pachytene checkpoint protein 2 homolog
, thyroid hormone receptor interactor 13 homolog
, thyroid receptor-interacting protein 13 homolog
, Thyroid hormone receptor interactor 13 homolog
, Thyroid receptor-interacting protein 13 homolog
, thyroid hormone receptor interactor 13
, thyroid receptor-interacting protein 13-like
, HPV16 E1 protein binding protein
, HPV16 E1 protein-binding protein
, TR-interacting protein 13
, human papillomavirus type 16 E1 protein-binding protein
, thyroid receptor interacting protein 13
, thyroid receptor-interacting protein 13
, Pachytene checkpoint protein 2 homolog
, Thyroid receptor-interacting protein 13