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The protein encoded by THAP11 contains a THAP domain, which is a conserved DNA-binding domain that has striking similarity to the site-specific DNA-binding domain (DBD) of Drosophila P element transposases..
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Human Monoclonal THAP11 Primary Antibody für BI, IF - ABIN2689892
Dejosez, Levine, Frampton, Whyte, Stratton, Barton, Gunaratne, Young, Zwaka: Ronin/Hcf-1 binds to a hyperconserved enhancer element and regulates genes involved in the growth of embryonic stem cells. in Genes & development 2010
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Human Monoclonal THAP11 Primary Antibody für ICC, FACS - ABIN969436
Li, McInnis, Margolis, Antonarakis, Ross: Novel triplet repeat containing genes in human brain: cloning, expression, and length polymorphisms. in Genomics 1993
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Human Polyclonal THAP11 Primary Antibody für IF, WB - ABIN528142
Nakamura, Yokota, Tan, Nagata, Takemura, Hirano, Shigeno, Shibata, Fujisawa, Ohnishi: Down-regulation of Thanatos-associated protein 11 by BCR-ABL promotes CML cell proliferation through c-Myc expression. in International journal of cancer. Journal international du cancer 2011
Cow (Bovine) Polyclonal THAP11 Primary Antibody für ELISA - ABIN4247424
Zhu, Li, Li, Zhan, Li, Xu, Xu, Sun, Yang: Cell growth suppression by thanatos-associated protein 11(THAP11) is mediated by transcriptional downregulation of c-Myc. in Cell death and differentiation 2009
We sequenced THAP11 by Sanger sequencing and discovered a potentially pathogenic, homozygous variant in THAP11, c.240C > G (p.Phe80Leu). Further, we provide functional data in model organisms that suggests that both HCFC1 (zeige HCFC1 Antikörper) and THAP11 are essential for normal brain development and neural precursor differentiation.
the crystal structure of the C-ter (zeige TECR Antikörper) region of THAP11 forms a left-handed parallel homo-dimeric coiled-coil structure possessing several unusual features.
The M4 motif (ACTAYRNNNCCCR) is a functional regulatory bipartite cis (zeige CISH Antikörper)-element, which engages a THAP11/HCF-1 (zeige HCFC1 Antikörper) complex via binding to the ACTAYR module, while the CCCRRNRNRC subsequence part constitutes a binding platform for Ikaros (zeige IKZF1 Antikörper) and NFKB1 (zeige NFKB1 Antikörper)
THAP11, ZNF143 (zeige ZNF143 Antikörper), and HCF-1 (zeige HCFC1 Antikörper) form a mutually dependent complex on chromatin, which is independent of E2F (zeige E2F1 Antikörper) occupancy.
that THAP11 reversibly regulated erythroid and megakaryocytic differentiation.
HCFC1 (zeige HCFC1 Antikörper) is a common component of active human CpG-island promoters and coincides with ZNF143 (zeige ZNF143 Antikörper), THAP11, YY1 (zeige YY1 Antikörper), and GABP transcription factor occupancy.
In HCC (zeige FAM126A Antikörper) patients, the expression of THAP11 mRNA significantly correlated with PCBP1 (zeige PCBP1 Antikörper) mRNA expression. Our results suggest a novel role of THAP11 in CD44 (zeige CD44 Antikörper) alternative splicing and hepatoma invasion
identify THAP11 as a transcriptional regulator differentially expressed in human colon cancer
the induced THAP11 might be one of transcriptional regulators of c-Myc expression in CML cell.
Results suggest that THAP11 functions as a cell growth suppressor by negatively regulating the expression of c-Myc (zeige MYC Antikörper).
The activity of Ronin coincided with the recruitment of its cofactor, Hcf-1 (zeige HCFC1 Antikörper), and the elevation of H3K4me3 levels at specific target genes, suggesting the involvement of an epigenetic mechanism.
Ronin binds to and regulates the genes encoding several DNA repair factors, including Gtf2h4 (zeige GTF2H4 Antikörper) and Rad18 (zeige RAD18 Antikörper), providing a potential mechanism for this phenotype.
Ronin is a positive regulator of mitochondrial gene expression that coordinates mitochondrial activity and cell cycle progression in the developing retina.
Ronin/Hcf-1 (zeige HCFC1 Antikörper) controls a genetic program that contributes to the unimpeded growth of embryonic stem cells.
Findings identify Ronin as an essential factor underlying embryogenesis and ES cell pluripotency; its association with HCF-1 (zeige HCFC1 Antikörper) suggests an epigenetic mechanism of gene repression in pluripotent cells.
The protein encoded by this gene contains a THAP domain, which is a conserved DNA-binding domain that has striking similarity to the site-specific DNA-binding domain (DBD) of Drosophila P element transposases.
THAP domain-containing protein 11
, THAP domain containing 11