T-Cell Leukemia Homeobox 3 Proteine (TLX3)

RNX (HOX11L2, TLX3) belongs to a family of orphan homeobox genes that encode DNA-binding nuclear transcription factors. Zusätzlich bieten wir Ihnen TLX3 Antikörper (39) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
TLX3 30012 O43711
TLX3 27140  
Ratte TLX3 TLX3 497881  
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 11 Days
Hefe Huhn His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage

TLX3 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,
Mouse (Murine)

Weitere Proteine zu T-Cell Leukemia Homeobox 3 (TLX3) Interaktionspartnern

Human T-Cell Leukemia Homeobox 3 (TLX3) Interaktionspartner

  1. Egyptian T-cell acute lymphoblastic leukemia cases seemed to have a different genetic pattern compared to other populations, with a lower incidence of TLX3/HOX11L2 and SIL/TAL but a higher incidence of NKX2-5 expression than recorded in Western countries

  2. Immunophenotyping with CD135 and CD117 predicts the FLT3, IL-7R and TLX3 gene mutations in childhood T-cell acute leukemia.

  3. Studies suggest that homeobox protein TLX3 expression is not an indicator for the prognosis of pediatric T cell acute lymphocytic leukemia (T-ALL).

  4. these results place TLX1 and TLX3 at the top of an oncogenic transcriptional network controlling leukemia development, and identify RUNX1 as a tumor-suppressor gene in T-ALL

  5. The cortical thymic maturation arrest in T-lineage Acute lymphoblastic leukemias (ALLs) that overexpress TLX1 or TLX3 is due to binding of TLX1/TLX3 to ETS1.

  6. We found that 22 (21%) out of 110 clinical samples of bladder cancer showed the methylated pattern using the COBRA assay in TLX3. We found a correlation between TLX3 methylation and the sensitivity to cisplatin in the clinical samples by SDI test.

  7. Results identify Tlx3 as a novel target for canonical Wnt signaling that confers somatic stem cells with a sensory neuron phenotype upon neural induction.

  8. High TLX3/BCL11B fusion protein expression is associated with T/myeloid acute bilineal leukemia.

  9. HOX11L2 expression defines a clinical subtype of pediatric T-ALL associated with poor prognosis.

  10. Authors conclude that RNX, and presumably its expression, are not altered in the index cases of congenital central hypoventilation syndrome.

  11. High incidence of Hox11L2 expression in children with T-ALL

  12. Translocations in Hox11L2 locus is associated with T-cell acute lymphoblastic leukemia

  13. HOX11L2 expression is linked to chromosomes 5 and 14 in T-cell malignancies in children.

  14. TLX3 expression in T-ALL is strongly associated with the presence of genomic rearrangements

  15. The TLX3 protein is high levels expressed in the leukemia cells in keeping with the presence of t(5;14)(q35;q14) in leukemia cells.

  16. The Significance of HOX11L2/TLX3 expression in children with T-cell acute lymphoblastic leukemia treated on Children's Cancer Group protocols.

  17. The present report is focused on the identification of elements and factors playing a role in the TLX3 physiologic expression regulation and therefore likely to be involved in cancer development.

  18. In T-cell acute lymphoblastic leukemia, alternative t(5;14)(q35;q32.2) forms effect dysregulation of either TLX3 or NKX2-5 homeobox genes at 5q35 by juxtaposition with 14q32.2 breakpoints dispersed across the BCL11B downstream genomic desert.

  19. five recurrent genomic deletions in TLX3 rearranged T-ALL; genome-wide overview of copy number changes in TLX3 rearranged T-ALL

  20. Aberrant HOX11L2 expression is associated with thymic adult T-cell acute lymphoblastic leukemia

Mouse (Murine) T-Cell Leukemia Homeobox 3 (TLX3) Interaktionspartner

  1. These results demonstrate a novel role for Tlx3 and indicate that Pax6-Tlx3 expression and interaction is part of a region specific regulatory network in cerebellum and its deregulation during development could possibly lead to Autistic spectral disorders (ASD).

  2. Tlx3 promotes glutamatergic neuronal subtype specification through direct interactions with the chromatin modifier CBP.

  3. Tlx3 uses distinct mechanisms to tightly modulate Prrxl1 activity, either by controlling its transcriptional levels or by increasing Prrxl1 phosphorylation state.

  4. The tlx2 knockout mice failed to exhibit escape response evoked by dynamic mechanical stimuli but retained the ability to sense innocuous cooling and/or warm and development of a subset of excitatory neurons located in laminae I and II was impaired.

  5. Tlx3 is required for the acquisition of cholinergic phenotype at the late embryonic stage as well as the expression and maintenance of cholinergic peptides

  6. This study demonistrated that Tlx3 and Runx1 act in combination to coordinate the development of nociceptors, thermoceptors, and pruriceptors.

  7. Tlx1/3 and Ptf1a, the key transcription factors for fate determination of glutamatergic and GABAergic neurons in the dorsal spinal cord

  8. This study found that Tlx3 was required for specification of, and expressed in, glutamatergic neurons. and ectopic expression of Tlx3 was sufficient to suppress GABAergic differentiation and induce formation of glutamatergic neurons.

  9. Lbx1 and Tlx3 are opposing switches in determining GABAergic versus glutamatergic transmitter phenotypes.

  10. The sequential and coordinated expression of the proneural and neuronal subtype-specific genes identifies Tlx3 as a selector gene in ES cells undergoing neural differentiation

Zebrafish T-Cell Leukemia Homeobox 3 (TLX3) Interaktionspartner

  1. identification and expression patterns of three members of the zebrafish Tlx family

TLX3 Protein Überblick

Protein Überblick

RNX (HOX11L2, TLX3) belongs to a family of orphan homeobox genes that encode DNA-binding nuclear transcription factors. Members of the HOX11 gene family are characterized by a threonine-47 replacing cytosine in the highly conserved homeodomain (Dear et al., 1993

Genbezeichner und Symbole assoziert mit TLX3

  • T-cell leukemia homeobox 3 (TLX3)
  • T-cell leukemia homeobox 3 S homeolog (tlx3.S)
  • T-cell leukemia homeobox 3 (tlx3)
  • T cell leukemia, homeobox 3 (Tlx3)
  • T-cell leukemia, homeobox 3 (Tlx3)
  • T-cell leukemia homeobox 3 (Tlx3)
  • T-cell leukemia, homeobox 3b (tlx3b)
  • Hox11l2 Protein
  • RGD1564190 Protein
  • Rnx Protein
  • TLX-3 Protein
  • Tlx-3b Protein
  • Tlx1l2 Protein
  • TLX3 Protein
  • tlx3-a Protein
  • XHox11L2 Protein
  • ztlx-3b Protein

Bezeichner auf Proteinebene für TLX3

T-cell leukemia homeobox protein 3 , T-cell leukemia, homeobox 3 , homeo box 11-like 2 , homeobox protein Hox-11L2 , T-cell leukemia homeobox 3 , homeobox protein 11-like 2 , homeobox TLX-3 , respiratory neuron homeobox protein , tlx3

30012 Homo sapiens
373831 Xenopus laevis
395867 Gallus gallus
471737 Pan troglodytes
489123 Canis lupus familiaris
548656 Xenopus (Silurana) tropicalis
618473 Bos taurus
100340221 Oryctolagus cuniculus
27140 Mus musculus
497881 Rattus norvegicus
100724310 Cavia porcellus
266965 Danio rerio
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