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RNX (HOX11L2, TLX3) belongs to a family of orphan homeobox genes that encode DNA-binding nuclear transcription factors. Zusätzlich bieten wir Ihnen TLX3 Antikörper (39) und viele weitere Produktgruppen zu diesem Protein an.
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Egyptian T-cell acute lymphoblastic leukemia cases seemed to have a different genetic pattern compared to other populations, with a lower incidence of TLX3/HOX11L2 and SIL (zeige PMEL Proteine)/TAL (zeige TALDO1 Proteine) but a higher incidence of NKX2-5 (zeige NKX2-5 Proteine) expression than recorded in Western countries
Immunophenotyping with CD135 (zeige FLT3 Proteine) and CD117 predicts the FLT3 (zeige FLT3 Proteine), IL-7R and TLX3 gene mutations in childhood T-cell acute leukemia.
Studies suggest that homeobox protein TLX3 expression is not an indicator for the prognosis of pediatric T cell acute lymphocytic leukemia (T-ALL).
these results place TLX1 (zeige TLX1 Proteine) and TLX3 at the top of an oncogenic transcriptional network controlling leukemia development, and identify RUNX1 (zeige RUNX1 Proteine) as a tumor-suppressor gene in T-ALL
The cortical thymic maturation arrest in T-lineage Acute lymphoblastic leukemias (ALLs) that overexpress TLX1 (zeige TLX1 Proteine) or TLX3 is due to binding of TLX1 (zeige TLX1 Proteine)/TLX3 to ETS1 (zeige ETS1 Proteine).
We found that 22 (21%) out of 110 clinical samples of bladder cancer showed the methylated pattern using the COBRA assay in TLX3. We found a correlation between TLX3 methylation and the sensitivity to cisplatin in the clinical samples by SDI test.
Results identify Tlx3 as a novel target for canonical Wnt (zeige WNT2 Proteine) signaling that confers somatic stem cells with a sensory neuron phenotype upon neural induction.
High TLX3/BCL11B fusion protein expression is associated with T/myeloid acute bilineal leukemia.
HOX11L2 expression defines a clinical subtype of pediatric T-ALL associated with poor prognosis.
Authors conclude that RNX, and presumably its expression, are not altered in the index cases of congenital central hypoventilation syndrome.
These results demonstrate a novel role for Tlx3 and indicate that Pax6 (zeige PAX6 Proteine)-Tlx3 expression and interaction is part of a region specific regulatory network in cerebellum and its deregulation during development could possibly lead to Autistic spectral disorders (ASD (zeige GUSB Proteine)).
Tlx3 promotes glutamatergic neuronal subtype specification through direct interactions with the chromatin modifier CBP (zeige CREBBP Proteine).
Tlx3 uses distinct mechanisms to tightly modulate Prrxl1 (zeige DRGX Proteine) activity, either by controlling its transcriptional levels or by increasing Prrxl1 (zeige DRGX Proteine) phosphorylation state.
The tlx2 (zeige TLX2 Proteine) knockout mice failed to exhibit escape response evoked by dynamic mechanical stimuli but retained the ability to sense innocuous cooling and/or warm and development of a subset of excitatory neurons located in laminae I and II was impaired.
Tlx3 is required for the acquisition of cholinergic phenotype at the late embryonic stage as well as the expression and maintenance of cholinergic peptides
This study demonistrated that Tlx3 and Runx1 (zeige RUNX1 Proteine) act in combination to coordinate the development of nociceptors, thermoceptors, and pruriceptors.
Tlx1 (zeige TLX1 Proteine)/3 and Ptf1a (zeige PTF1A Proteine), the key transcription factors for fate determination of glutamatergic and GABAergic neurons in the dorsal spinal cord
This study found that Tlx3 was required for specification of, and expressed in, glutamatergic neurons. and ectopic expression of Tlx3 was sufficient to suppress GABAergic differentiation and induce formation of glutamatergic neurons.
Lbx1 (zeige Lbx1 Proteine) and Tlx3 are opposing switches in determining GABAergic versus glutamatergic transmitter phenotypes.
The sequential and coordinated expression of the proneural and neuronal subtype-specific genes identifies Tlx3 as a selector gene in ES cells undergoing neural differentiation
RNX (HOX11L2, TLX3) belongs to a family of orphan homeobox genes that encode DNA-binding nuclear transcription factors. Members of the HOX11 gene family are characterized by a threonine-47 replacing cytosine in the highly conserved homeodomain (Dear et al., 1993
T-cell leukemia homeobox protein 3
, T-cell leukemia, homeobox 3
, homeo box 11-like 2
, homeobox protein Hox-11L2
, T-cell leukemia homeobox 3
, homeobox protein 11-like 2
, homeobox TLX-3
, respiratory neuron homeobox protein