Symplekin Proteine (SYMPK)

SYMPK encodes a nuclear protein that functions in the regulation of polyadenylation and promotes gene expression. Zusätzlich bieten wir Ihnen Symplekin Antikörper (52) und Symplekin Kits (2) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
SYMPK 8189 Q92797
SYMPK 68188  
Ratte SYMPK SYMPK 292683  
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Showing 6 out of 6 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
Escherichia coli (E. coli) Maus His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 10 bis 12 Tage
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
Escherichia coli (E. coli) Human T7 tag,His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage

SYMPK Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
, , ,
Mouse (Murine) ,

Weitere Proteine zu Symplekin (SYMPK) Interaktionspartnern

Human Symplekin (SYMPK) Interaktionspartner

  1. Data indicate rs56848936 in the gene symplekin protein (SYMPK) at 19q13.3, associated with colon cancer risk.

  2. CPSF2 (zeige CPSF2 Proteine) and SYMPK, are RBFOX2 (zeige RBM9 Proteine) cofactors for both inclusion and exclusion of internal exons.

  3. Symplekin interacts and co-localizes with both MOZ and MLL (zeige MLL Proteine) in immature hematopoietic cells. Its inhibition leads to a decrease of the HOXA9 (zeige HOXA9 Proteine) protein level but not of Hoxa9 (zeige HOXA9 Proteine) mRNA.

  4. Symplekin expression regulates the assembly of tight junctions, thus helps to maintain the integrity of the epithelial monolayer and cellular polarity.

  5. crystal structure at 2.4 A resolution of the amino-terminal domain (residues 30-340) of human symplekin in a ternary complex with the Pol II carboxy-terminal domain (CTD) Ser (zeige SIGLEC1 Proteine) 5 phosphatase Ssu72 (zeige SSU72 Proteine) and a CTD Ser (zeige SIGLEC1 Proteine) 5 phosphopeptide

  6. Symplekin supports faithful mitosis by contributing to the formation of a bipolar spindle apparatus. Depletion of symplekin attenuates microtubule polymerization as well as expression of the critical microtubule polymerization protein CKAP5 (TOGp).

  7. Data show that claudin-2 (zeige CLDN2 Proteine) expression was reduced following symplekin down-regulation, and siRNA-mediated claudin-2 (zeige CLDN2 Proteine) down-regulation increased the transepithelial resistance and decreased cyclin D1 (zeige CCND1 Proteine) expression and ZONAB (zeige CSDA Proteine) nuclear localization.

  8. symplekin has a role in HSF1 (zeige HSF1 Proteine) modulation of Hsp70 (zeige HSP70 Proteine) mRNA polyadenylation

  9. The decreased expression of symplekin may be an early step in the transformation of hepatocytes, whereas alteration of the expression of adherens junctions and desmosomes may indicate more serious changes.

  10. The symplekin/ZONAB (zeige CSDA Proteine) complex inhibits intestinal cell differentiation by the repression of AML1/Runx1 (zeige RUNX1 Proteine).

Fruit Fly (Drosophila melanogaster) Symplekin (SYMPK) Interaktionspartner

  1. Authors propose a model in which the core cleavage complex formation is mediated by CPSF73 (zeige CPSF3 Proteine), CPSF100 (zeige CPSF2 Proteine), and Symplekin C-termini, and the N-terminal region of Symplekin facilitates cotranscriptional 3' end processing of histone mRNAs.

  2. This localization depends on the RNA binding protein ypsilon schachtel. CPSF-73 (zeige CPSF3 Proteine) and a number of mRNAs are localized at this same site, suggesting that Symplekin participates in cytoplasmic polyadenylation at tricellular junctions.

  3. Together, these data support the conclusion that the Symplekin HEAT domain serves as a scaffold for protein-protein interactions essential to the mRNA maturation process.

Xenopus laevis Symplekin (SYMPK) Interaktionspartner

  1. Here, we identify a new factor essential for polyadenylation, namely, symplekin, a CPEB and CPSF (zeige CPSF2 Proteine) binding protein that serves as a scaffold upon which regulatory factors are assembled

Arabidopsis thaliana Symplekin (SYMPK) Interaktionspartner

Symplekin (SYMPK) Protein Überblick

Protein Überblick

This gene encodes a nuclear protein that functions in the regulation of polyadenylation and promotes gene expression. The protein forms a high-molecular weight complex with components of the polyadenylation machinery. It is thought to serve as a scaffold for recruiting regulatory factors to the polyadenylation complex. It also participates in 3'-end maturation of histone mRNAs, which do not undergo polyadenylation. The protein also localizes to the cytoplasmic plaques of tight junctions in some cell types.

Genbezeichner und Symbole assoziert mit Symplekin Proteine (SYMPK)

  • symplekin (SYMPK)
  • Symplekin (Sym)
  • symplekin (Sympk)
  • symplekin S homeolog (sympk.S)
  • symplekin (sympk)
  • symplekin (LOC552752)
  • symplekin (AT1G27595)
  • symplekin (LOC5580150)
  • symplekin (CpipJ_CPIJ011126)
  • Symplekin (Bm1_50390)
  • symplekin (NAEGRDRAFT_80124)
  • symplekin (LOAG_00841)
  • 1500016F02Rik Protein
  • 4632415H16Rik Protein
  • AA125406 Protein
  • AI449890 Protein
  • CG2097 Protein
  • DKFZp468C0711 Protein
  • Dmel\\CG2097 Protein
  • dSymp Protein
  • Hfn3g Protein
  • MGC75595 Protein
  • SPK Protein
  • SYM Protein
  • SYMPK Protein
  • T22C5.3 Protein

Bezeichner auf Proteinebene für Symplekin Proteine (SYMPK)

CG2097-PA , Sym-PA , symplekin , hepatocyte nuclear factor 3 gamma , Symplekin , symplekin-like , LOW QUALITY PROTEIN: symplekin

8189 Homo sapiens
40709 Drosophila melanogaster
68188 Mus musculus
292683 Rattus norvegicus
379378 Xenopus laevis
394872 Xenopus (Silurana) tropicalis
456142 Pan troglodytes
476431 Canis lupus familiaris
552752 Apis mellifera
839651 Arabidopsis thaliana
5580150 Aedes aegypti
6043768 Culex quinquefasciatus
6104963 Brugia malayi
8853240 Naegleria gruberi strain NEG-M
9938210 Loa loa
100010885 Monodelphis domestica
100070949 Equus caballus
100174376 Pongo abelii
100179022 Ciona intestinalis
100337373 Bos taurus
100348044 Oryctolagus cuniculus
100412467 Callithrix jacchus
100474335 Ailuropoda melanoleuca
100512609 Sus scrofa
100714088 Cavia porcellus
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