Suppressor of Variegation 4-20 Homolog 2 (Drosophila) Proteine (SUV420H2)

Human Suppressor of Variegation 4-20 Homolog 2 (Drosophila) (SUV420H2) Interaktionspartner

1. Study provides evidence that Suv420h2 controls the H4K20 methylome of osteoblasts and is critical for normal progression of osteoblastogenesis.

2. Altogether, these results reveal Suv4-20h-mediated histone H4K20 tri (zeige VANGL2 Proteine)-methylation as a critical determinant in the selection of active replication initiation sites in heterochromatin regions of mammalian genomes.

3. The sequences surrounding both methylation sites do not fit to the specificity profile of SUV4-20H1 (zeige SUV420H1 Proteine).

4. Upregulation of long non-coding RNA PAPAS (zeige PSTPIP1 Proteine) in response to hypoosmotic stress does not increase H4K20me3 because of Nedd4 (zeige NEDD4 Proteine)-dependent ubiquitinylation and proteasomal degradation of Suv4-20h2.

5. One of the most downregulated genes in response to SUV420H2 expression was the Src (zeige SRC Proteine) substrate, tensin-3 (zeige TNS3 Proteine), a focal adhesion protein that contributes to cancer cell migration.

6. The crystal structure of SUV420H2 was used to characterize substrate selectivity and product specificity.

7. SUV420H1 (zeige SUV420H1 Proteine) and SUV420H2 isoforms have different in their cellular localization and effects on myogenic differentiation

8. data indicate that H4K20me3 invokes gene repression by antagonizing hMOF (zeige KAT8 Proteine)-mediated H4K16Ac

9. The decrease in trimethylation of lysine 20 of histone H4 in breast cancer cells was accompanied by diminished expression of Suv4-20h2 histone methyltransferase.

Mouse (Murine) Suppressor of Variegation 4-20 Homolog 2 (Drosophila) (SUV420H2) Interaktionspartner

1. expression of Suv4-20h2 leads to sustained levels of H4K20me3, developmental arrest, and defects in S-phase progression.

2. Upregulation of long non-coding RNA PAPAS (zeige PSTPIP1 Proteine) in response to hypoosmotic stress does not increase H4K20me3 because of Nedd4-dependent ubiquitinylation and proteasomal degradation of Suv4-20h2.

3. Results uncover a lncRNA-mediated mechanism that guides Suv4-20h2 to specific genomic loci to establish a more compact chromatin structure in growth-arrested cells.

4. Data suggest that Suv4-20h1 (zeige SUV420H1 Proteine)/Suv4-20h2 activity is required for fidelity of chromosome distribution during meiosis in oocyte; Suv4-20h1 (zeige SUV420H1 Proteine)/Suv4-20h2 appear to control histone 4 methylation, centromere structure, and oocyte maturation/oogenesis.

5. Suv4-20h2 is involved in the initial loading or maintenance of cohesion subunits

6. SUV420H1 (zeige SUV420H1 Proteine) and SUV420H2 isoforms have different in their cellular localization and effects on myogenic differentiation