Sprouty Homolog 4 (Drosophila) Proteine (SPRY4)

Human Sprouty Homolog 4 (Drosophila) (SPRY4) Interaktionspartner

1. Results show that SPRY4 expression level was significantly decreased in glioma tissues, associated with short survival time, and a key target gene of miR (zeige MLXIP Proteine)-1908.

2. Our data indicate that KMT2C ELs are associated with specific genetic features and that SPRY4 ELs may add prognostic information.

3. Studied BAK1 (zeige BAK1 Proteine), SPRY4 and GAB2 (zeige GAB2 Proteine) SNPs in pediatric germ cell tumors(GCT (zeige QPCT Proteine)); found a variant in SPRY4 was associated with reduced risk of GCT (zeige QPCT Proteine); a variant in BAK1 (zeige BAK1 Proteine) was positively associated with GCT (zeige QPCT Proteine) with a strong estimated effect for testis tumors; and a SNP in GAB2 (zeige GAB2 Proteine) was associated with increased risk for GCT (zeige QPCT Proteine).

4. results found that histone methylation mediated by CCAT1 could also contribute to the lower expression of SPRY4 in esophageal squamous cell carcinoma

5. mechanistic evidence that KSRP (zeige KHSRP Proteine) promotes the down-regulation of Spry4 by a previously unidentified mechanism, i.e. post-transcriptional mRNA regulation.

6. Polymorphisms of KITLG (zeige KITLG Proteine), SPRY4, and BAK1 (zeige BAK1 Proteine) genes in patients with testicular germ cell tumors and individuals with infertility associated with AZFc deletion of the Y chromosome

7. SPRY4 is involved in the development and progression of colorectal cancer.

8. Small interfering RNA (siRNA)-mediated knockdown of SPRY4 attenuated the AREG (zeige AREG Proteine)-induced down-regulation of E-cadherin (zeige CDH1 Proteine).

9. These findings suggest that SPRY4-IT1 (zeige HAUS3 Proteine) plays a direct role in the regulation of metastasis and progression of osteosarcoma.

10. Results identify the tumor suppressor SPRY4 as a novel molecular effector of MT1-MMP (zeige MMP14 Proteine) affecting melanoma cell motility.

Mouse (Murine) Sprouty Homolog 4 (Drosophila) (SPRY4) Interaktionspartner

1. A Sprouty4 reporter to monitor FGF/ERK (zeige EPHB2 Proteine) signaling activity in ESCs (zeige NR2E3 Proteine) and mice.

2. Irf6 (zeige IRF6 Proteine) and RTK signaling interact in regulating periderm differentiation and function, as well as provide a rationale to screen for epistatic interactions between variants in IRF6 (zeige IRF6 Proteine) and RTK signaling pathway genes in human orofacial clefting populations.

3. In the present study, it is demonstrated that Spry2 (zeige SPRY2 Proteine) and -4 participate in KA induced neurodegeneration possibly through inhibition of ERK (zeige EPHB2 Proteine) signaling.

4. Autoregulatory loop between TGF-beta1 (zeige TGFB1 Proteine)/miR (zeige MLXIP Proteine)-411-5p/SPRY4 and p38 MAPK (zeige MAPK14 Proteine) pathway in rhabdomyosarcoma modulates proliferation and differentiation.

5. in embryos with lower Spry2 (zeige SPRY2 Proteine);Spry4 gene dosages, we observed a non-fusion of original R2 and M1 Shh (zeige SHH Proteine) signaling domains with consequent formation of a supernumerary tooth primordium from the isolated R2 bud

6. We demonstrate that in spry4-/- mice inflammatory responses, such TNFalpha (zeige TNF Proteine) secretion and macrophage/neutrophil invasion into the lesion site are reduced. In addition, astrocytic gliosis is attenuated and neuronal survival is increased.

7. SPRY4 is a tumor suppressor at 5q whose disruption contributes to a lethal acute myeloid leukemia (zeige BCL11A Proteine) subtype.

8. In vivo analysis revealed that Spry4 regulated integrin beta3 levels in murine embryos and yolk sacs.

9. We propose that Sprouty genes(Spry2 (zeige SPRY2 Proteine) and Spry4) were implicated during evolution in reduction of the cheek teeth in Muridae, and their deletion can reveal ancestral stages of murine dental evolution.

10. ISG15 mRNA expression and IFN-dependent antiviral responses are enhanced in Spry1,2,4 triple knock-out mouse embryonic fibroblasts, consistent with negative feedback regulatory roles for Spry proteins in IFN-mediated signaling.