Sprouty Homolog 4 (Drosophila) Proteine (SPRY4)

SPRY4 is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. Zusätzlich bieten wir Ihnen SPRY4 Antikörper (90) und und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
Ratte SPRY4 SPRY4 291610  
SPRY4 81848 Q9C004
SPRY4 24066 Q9WTP2
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 13 bis 16 Tage
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
Hefe Rind (Kuh) His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage

SPRY4 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
Mouse (Murine)

Weitere Proteine zu Sprouty Homolog 4 (Drosophila) (SPRY4) Interaktionspartnern

Human Sprouty Homolog 4 (Drosophila) (SPRY4) Interaktionspartner

  1. The findings indicate that SPRY4 and SPRY4-IT1 may act as oncogenes in testicular germ cell tumors via activation of the PI3K/Akt signaling pathway.

  2. Results show that SPRY4 expression level was significantly decreased in glioma tissues, associated with short survival time, and a key target gene of miR-1908.

  3. Our data indicate that KMT2C ELs are associated with specific genetic features and that SPRY4 ELs may add prognostic information.

  4. Studied BAK1, SPRY4 and GAB2 SNPs in pediatric germ cell tumors(GCT); found a variant in SPRY4 was associated with reduced risk of GCT; a variant in BAK1 was positively associated with GCT with a strong estimated effect for testis tumors; and a SNP in GAB2 was associated with increased risk for GCT.

  5. results found that histone methylation mediated by CCAT1 could also contribute to the lower expression of SPRY4 in esophageal squamous cell carcinoma

  6. mechanistic evidence that KSRP promotes the down-regulation of Spry4 by a previously unidentified mechanism, i.e. post-transcriptional mRNA regulation.

  7. Polymorphisms of KITLG, SPRY4, and BAK1 genes in patients with testicular germ cell tumors and individuals with infertility associated with AZFc deletion of the Y chromosome

  8. SPRY4 is involved in the development and progression of colorectal cancer.

  9. Small interfering RNA (siRNA)-mediated knockdown of SPRY4 attenuated the AREG-induced down-regulation of E-cadherin.

  10. These findings suggest that SPRY4-IT1 plays a direct role in the regulation of metastasis and progression of osteosarcoma.

  11. Results identify the tumor suppressor SPRY4 as a novel molecular effector of MT1-MMP affecting melanoma cell motility.

  12. Data show that proto-oncogene protein B-raf (BRAF) inhibition induces c-Jun N-terminal kinase (c-JUN) expression and c-JUN abundance and activation by down-regulating SPRY2/4 protein expression.

  13. Specific protein 1 plays a crucial role in the regulation of Sprouty4 in response to serum.

  14. ZNF703 was a target of SPRY4-IT1.

  15. SPRY4 is often deleted in secondary acute myeloid leukemia.

  16. Sprouty 2 protein, but not Sprouty 4, is an independent prognostic biomarker for human epithelial ovarian cancer.

  17. these results suggest the possibility that SPRY4-IT1 knockdown may induce apoptosis via lipin 2-mediated alterations in lipid metabolism leading to cellular lipotoxicity.

  18. SPRY4 may function as a tumor suppressor in endometrial adenocarcinoma.

  19. Downregulation of Dusp6, Sprouty4, and Sef--negative modulators of FGF2/ERK1/2 signaling--was present in eutopic endometria of adenomyosis, which may play critical roles in the development of adenomyosis.

  20. demonstrated that knockdown of SPRY4-IT1 reduced cell proliferation, invasiveness, and migration

SPRY4 Protein Überblick

Protein Überblick

SPRY4 is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. It is positioned upstream of RAS (see HRAS\; MIM 190020) activation and impairs the formation of active GTP-RAS (Leeksma et al., 2002

Genbezeichner und Symbole assoziert mit SPRY4

  • sprouty RTK signaling antagonist 4 (Spry4)
  • sprouty RTK signaling antagonist 4 (SPRY4)
  • sprouty (Drosophila) homolog 4 (spry4)
  • sprouty homolog 4 (Drosophila) (Spry4)
  • A030006O18Rik Protein
  • HH17 Protein
  • LOC100218545 Protein
  • sprouty4 Protein
  • SPRY4 Protein

Bezeichner auf Proteinebene für SPRY4

protein sprouty homolog 4 , sprouty-like protein 4 , sprouty homolog 4 , SPRY domain-containing protein 4 , spry-4

291610 Rattus norvegicus
427643 Gallus gallus
705836 Macaca mulatta
100195736 Salmo salar
100218545 Taeniopygia guttata
81848 Homo sapiens
24066 Mus musculus
504593 Bos taurus
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