Sphingomyelin Synthase 2 Proteine (SGMS2)

Human Sphingomyelin Synthase 2 (SGMS2) Interaktionspartner

1. SMS (zeige SMS Proteine) regulates the expression and function of drug transporters P-gp (zeige ABCB4 Proteine) and MRP2 (zeige ABCC2 Proteine).

2. PPARdelta (zeige PPARD Proteine) activation may be a potential risk of atherosclerosis through enhancing activity of SMS2

3. F-actin polymerization in the region of HIV-1 membrane fusion was more prominent in Sms2-expressing cells than Sms (zeige SMS Proteine)-deficient cells.

4. SMS1 (zeige SGMS1 Proteine) and SMS2 are capable of regulating TGN (zeige TG Proteine)-mediated protein trafficking and secretion

5. Data indicate that the increased sphingomyelin mass was due to a rapid and highly specific activation of sphingomyelin synthases SMS1 (zeige SGMS1 Proteine) and SMS2.

6. direct morphological evidence for the pro-atherogenic capabilities of sphingomyelin synthase 2

7. Data show that SMS2 acting as a bifunctional enzyme with both SM and CPE synthase activity.

8. Data show that sphingomyelin synthases SMS1 (zeige SGMS1 Proteine) and SMS2 are co-expressed in a variety of cell types and function as the key Golgi- and plasma membrane-associated SM synthases in human cervical carcinoma HeLa cells, respectively.

9. Results indicate that both synthase (SMS)1 (zeige SGMS1 Proteine) and 2 contribute to sphingomyelin (SM) de novo synthesis and control SM levels in the cells and on the cell membrane including plasma membrane.

10. SMS2 is a key factor in control of sphingomyelin and diacylglycerol metabolism within the cell, and thus it influences apoptosis.

Mouse (Murine) Sphingomyelin Synthase 2 (SGMS2) Interaktionspartner

1. This study showed that MWM learning was deteriorated and associated with depression-like tendency in SMS2 KO mice.

2. These results demonstrate that SMS2 deficiency inhibits DSS (zeige PMP22 Proteine)-induced colitis and subsequent colitis-associated colon cancer via inhibition of colon epithelial cell-mediated inflammation; therefore, inhibition of SMS2 may be a potential therapeutic target for human colitis and colorectal cancer.

3. It was suggested that very long chain SM but not long chain SM were decreased in SMS2-deficient mice liver and plasma. And the exogenously added very long chain SM (d18:1/24:0) could activate macrophages directly, suggesting a novel role of plasma very long chain SM in modulating macrophage activation and resulting inflammation.

4. These findings suggested that the degree of lung injury was reduced during the acute inflammatory reaction when NFkappaB was inhibited, and that the expression of sphingomyelin synthase 2 may affect the induction of the NFkappaB pathway by lipopolysaccharide through CD14 (zeige CD14 Proteine).

5. Study provides a mouse model for fetal alcohol spectrum disorder. Due to the accumulation of ceramide in vivo, SMS2 knockout mice allows to investigate how ceramide regulates alcohol-induced neural apoptosis.

6. study provided evidence that genetic inhibition of SMS2 elevated glucose clearance through activation of glucose uptake into insulin (zeige INS Proteine)-targeted tissues such as skeletal muscle by a mechanism independent of hepatic SMS2

7. Thus, imaging mass spectrometry can provide visual assessment of the contribution of SMS2 on acyl-chain- and region-specific sphingomyelin metabolism in the kidneys

8. study reveals that all mouse SMS family members (SMSr, SMS1, and SMS2) have CPE synthase activity

9. Increasing ceramide levels in the liver can be achieved by SMS2 inhibition to prevent liver steatosis via PPARgamma (zeige PPARG Proteine) suppression.

10. Data show that LCAT (zeige LCAT Proteine) activity was significantly higher in long chain base biosynthesis protein 2 (Sptlc2 (zeige SPTLC2 Proteine))+/- and sphingomyelin synthase 2 (Sms2)-/- mice, but markedly lower in ApoE (zeige APOE Proteine)-/- and Ldlr (zeige LDLR Proteine)-/- mice.