Protein Überblick

This gene encodes a hormone inducible transcriptional repressor. Repression of transcription by this gene product can occur through interactions with other repressors, by the recruitment of proteins involved in histone deacetylation, or through sequestration of transcriptional activators. The product of this gene contains a carboxy-terminal domain that permits binding to other corepressor proteins. This domain also permits interaction with members of the NuRD complex, a nucleosome remodeling protein complex that contains deacetylase activity. In addition, this repressor contains several RNA recognition motifs that confer binding to a steroid receptor RNA coactivator\; this binding can modulate the activity of both liganded and nonliganded steroid receptors.

Genbezeichner und Symbole assoziert mit SPEN

• spen family transcriptional repressor (SPEN) Antikörper
• SPEN homolog, transcriptional regulator (Drosophila) (Spen) Antikörper

• HIAA0929 Antikörper
• Mint Antikörper
• mKIAA0929 Antikörper
• RBM15C Antikörper
• SHARP Antikörper

Bezeichner auf Proteinebene für SPEN

Msx2 interacting nuclear target (MINT) homolog , SMART/HDAC1 associated repressor protein , SMART/HDAC1-associated repressor protein , msx2-interacting protein , nuclear receptor transcription cofactor , spen homolog, transcriptional regulator (Drosophila) , Msx2 interacting nuclear target protein