anti-Spen Homolog, Transcriptional Regulator (Drosophila) (SPEN) Antikörper

SPEN encodes a hormone inducible transcriptional repressor.

Alle Antikörper anzeigen Gen GeneID UniProt
SPEN 23013 Q96T58
SPEN 56381 Q62504
SPEN    
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Top anti-SPEN Antikörper auf antikoerper-online.de

Showing 10 out of 21 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert ICC, IF, IHC, IHC (p), IP Immunohistochemistry-Paraffin: SPEN Antibody [NBP1-82952] - Staining of human rectum shows strong nuclear and slightly weaker cytoplasmic positivity in glandular cells. Immunocytochemistry/Immunofluorescence: SPEN Antibody [NBP1-82952] - Staining of human cell line U-251MG shows positivity in nuclei but not nucleoli. 0.1 mL Anmelden zum Anzeigen 7 bis 9 Tage
$491.63
Details
Human Ziege Unkonjugiert ELISA   0.1 mg Anmelden zum Anzeigen 7 bis 9 Tage
$373.75
Details
Human Kaninchen Unkonjugiert IP, WB Western Blot: SHARP Antibody [ABIN188789] - Detection of Human SHARP by Western Blot of Immunoprecipitates. Samples: Whole cell lysate (1 mg for IP, 20% of IP loaded) from HeLa cells. Antibodies: Affinity purified rabbit anti-SHARP antibody ABIN188789 used for IP at 3 mcg/mg lysate. SHARP was also immunoprecipitated by rabbit anti-SHARP antibody ABIN188790, which recognizes a downstream epitope.  Detection: Chemiluminescence with an exposure time of 3 minutes. 100 μL Anmelden zum Anzeigen 7 bis 9 Tage
$556.31
Details
Human Kaninchen Unkonjugiert IP Western Blot: SHARP Antibody [ABIN188790] - Detection of Human SHARP by Western Blot of Immunoprecipitates. Samples: Whole cell lysate (1 mg for IP, 20% of IP loaded) from HeLa cells. Antibodies: Affinity purified rabbit anti-SHARP antibody ABIN188790 used for IP at 3 mcg/mg lysate. SHARP was also immunoprecipitated by rabbit anti-SHARP antibody ABIN188789, which recognizes an upstream epitope.  Detection: Chemiluminescence with an exposure time of 3 minutes. 100 μL Anmelden zum Anzeigen 7 bis 9 Tage
$556.31
Details
Human Ziege Unkonjugiert ELISA, WB   100 μg Anmelden zum Anzeigen 6 bis 7 Tage
$242.88
Details
Human Kaninchen Unkonjugiert ICC, IF Immunocytochemistry/Immunofluorescence: SPEN Antibody  - Staining of human cell line A-431 shows localization to nucleoplasm. 100 μL Anmelden zum Anzeigen 10 bis 13 Tage
$491.63
Details
Human Ziege Unkonjugiert ELISA   0.1 mg Anmelden zum Anzeigen 2 bis 3 Tage
$446.88
Details
Human Ziege Unkonjugiert ELISA   100 μg Anmelden zum Anzeigen 7 bis 9 Tage
$507.83
Details
Hund Kaninchen Unkonjugiert IP   100 μL Anmelden zum Anzeigen 7 bis 9 Tage
$595.83
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Human Kaninchen Unkonjugiert IF, IHC (p)   100 μL Anmelden zum Anzeigen 11 bis 12 Tage
$460.00
Details

SPEN Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
Human , , , ,
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, , , , ,
Mouse (Murine)


Monkey ,
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Am meisten referenzierte anti-SPEN Antikörper

  1. Human Polyclonal SPEN Primary Antibody für ICC, IF - ABIN4355627 : McHugh, Chen, Chow, Surka, Tran, McDonel, Pandya-Jones, Blanco, Burghard, Moradian, Sweredoski, Shishkin, Su, Lander, Hess, Plath, Guttman: The Xist lncRNA interacts directly with SHARP to silence transcription through HDAC3. in Nature 2015 (PubMed)

  2. Human Polyclonal SPEN Primary Antibody für ELISA - ABIN251251 : Hiriart, Gruffat, Buisson, Mikaelian, Keppler, Meresse, Mercher, Bernard, Sergeant, Manet: Interaction of the Epstein-Barr virus mRNA export factor EB2 with human Spen proteins SHARP, OTT1, and a novel member of the family, OTT3, links Spen proteins with splicing regulation and mRNA export. in The Journal of biological chemistry 2005 (PubMed)

Weitere Antikörper gegen SPEN Interaktionspartner

Human Spen Homolog, Transcriptional Regulator (Drosophila) (SPEN) Interaktionspartner

  1. SPEN is a novel tumor-suppressor gene that may be clinically useful as a predictive biomarker of tamoxifen response in ERalpha (zeige ESR1 Antikörper)-positive breast cancers.

  2. SPEN mutations were associated with diffuse large B-cell lymphoma with hepatitis C virus infection.

  3. Phosphorylation of the CK2 site on SMRT significantly increased affinity for SHARP.

  4. These results demonstrate a role for the inactivation of SHARP transcription in DM1 biology.

  5. MINT3 (zeige APBA3 Antikörper) and MINT17 were informative for patient grouping to predict local recurrence in rectal cancer patients

  6. SHARP is a novel component of the HDAC (zeige HDAC3 Antikörper) corepressor complex, recruited by RBP (zeige RBP4 Antikörper)-Jkappa to repress transcription of target genes in the absence of activated Notch (zeige NOTCH1 Antikörper).

  7. the conserved function of the SPOC domain of SHARP is to mediate interaction with SMRT/NCoR (zeige NCOR1 Antikörper) corepressors, and that Spen proteins play an essential role in the repression complex

  8. both the androgen receptor (zeige AR Antikörper) interacting domains of the coactivator SRC1 (zeige SRC Antikörper) and of the corepressor SMRT compete for interaction with the androgen receptor (zeige AR Antikörper) N-terminus

  9. Pak1 (zeige PAK1 Antikörper)-SHARP interaction plays an essential role in enhancing the corepressor functions of SHARP, thereby modulating Notch (zeige NOTCH1 Antikörper) signaling in human cancer cells.

  10. Msx2-interacting protein(MINT), human interacts with the UbcH8 (zeige UBE2E2 Antikörper).

Mouse (Murine) Spen Homolog, Transcriptional Regulator (Drosophila) (SPEN) Interaktionspartner

  1. Spenito (zeige RBM15 Antikörper), a small Spen family member, counteracted Spen function in fat regulation. Finally, mouse Spen and Spenito (zeige RBM15 Antikörper) transcript levels scaled directly with body fat in vivo, suggesting a conserved role in fat liberation and catabolism. This study demonstrates that Spen is a key regulator of energy balance and provides a molecular context to understand the metabolic defects that arise from Spen dysfunction.

  2. Spen is required for gene repression by Xist. Spen is not required for Xist RNA localization and the recruitment of chromatin modifications.

  3. Spen is required for Xist-mediated silencing.

  4. results suggest that Xist silences transcription by directly interacting with SHARP, recruiting SMRT, activating HDAC3, and deacetylating histones to exclude Pol II across the X chromosome

  5. MINT forms a high affinity complex with CSL (zeige SMPX Antikörper); the domains of MINT and CSL (zeige SMPX Antikörper) that are necessary and sufficient for complex formation are delineated

  6. MINT plays an important role in tooth development, in particular, epithelial morphogenesis

  7. Notch1 (zeige NOTCH1 Antikörper) in concert with Notch2 (zeige NOTCH2 Antikörper) contributes to the morphogenesis of renal vesicles into S-shaped bodies in a RBP-J (zeige RBPJ Antikörper)-dependent manner.

  8. Msx2-interacting nuclear target protein (MINT) competed with the intracellular region of Notch (zeige NOTCH1 Antikörper) for binding to a DNA binding protein (zeige HSF4 Antikörper) RBP-J (zeige RBPJ Antikörper) and suppressed the transactivation activity of Notch (zeige NOTCH1 Antikörper) signaling.

  9. Stra13, Dec and Sharp (Mint) bHLH repressors are dynamically regulated during mammary gland development and may function to regulate apoptosis

  10. MINT enhances Runx2 (zeige RUNX2 Antikörper) activation of multiprotein complexes assembled by the OCFRE

SPEN Antigen-Profil

Protein Überblick

This gene encodes a hormone inducible transcriptional repressor. Repression of transcription by this gene product can occur through interactions with other repressors, by the recruitment of proteins involved in histone deacetylation, or through sequestration of transcriptional activators. The product of this gene contains a carboxy-terminal domain that permits binding to other corepressor proteins. This domain also permits interaction with members of the NuRD complex, a nucleosome remodeling protein complex that contains deacetylase activity. In addition, this repressor contains several RNA recognition motifs that confer binding to a steroid receptor RNA coactivator\; this binding can modulate the activity of both liganded and nonliganded steroid receptors.

Genbezeichner und Symbole assoziert mit SPEN

  • spen family transcriptional repressor (SPEN) Antikörper
  • SPEN homolog, transcriptional regulator (Drosophila) (Spen) Antikörper
  • HIAA0929 Antikörper
  • Mint Antikörper
  • mKIAA0929 Antikörper
  • RBM15C Antikörper
  • SHARP Antikörper

Bezeichner auf Proteinebene für SPEN

Msx2 interacting nuclear target (MINT) homolog , SMART/HDAC1 associated repressor protein , SMART/HDAC1-associated repressor protein , msx2-interacting protein , nuclear receptor transcription cofactor , spen homolog, transcriptional regulator (Drosophila) , Msx2 interacting nuclear target protein

GENE ID SPEZIES
23013 Homo sapiens
419460 Gallus gallus
56381 Mus musculus
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