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SP7 encodes a member of the Sp subfamily of Sp/XKLF transcription factors.
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Results showed that blocking miR (zeige MLXIP Proteine)-31 led to an increase in osterix protein in both cell types at day 7, with an increase in osteocalcin (zeige BGLAP Proteine) at day 21, suggesting MSC (zeige MSC Proteine) osteogenesis
Results provide evidence that CBP (zeige CREBBP Proteine)-mediated acetylation and HDAC4 (zeige HDAC4 Proteine)-mediated deacetylation have critical roles in the modification of Osx (zeige MID1 Proteine), and thus are important in osteoblast differentiation.
Osterix and RUNX2 (zeige RUNX2 Proteine) are transcriptional regulators of sclerostin (zeige SOST Proteine) in human bone
Osterix decreased the chemosensitivity of breast cancer cells by upregulating the expression of GALNT14 (zeige GALNT14 Proteine), which eventually suppressed the apoptosis of breast cancer cells.
TP(thymidine phosphorylase (zeige TYMP Proteine) ) curbed the expression of three proteins-IRF8 (zeige IRF8 Proteine), RUNX2 (zeige RUNX2 Proteine), and osterix. This downregulation was epigenetically driven: High levels of 2DDR, a product of TP secreted by myeloma cells, activated PI3K (zeige PIK3CA Proteine)/AKT (zeige AKT1 Proteine) signaling and increased the methyltransferase DNMT3A's expression
dissection of these interconnected epigenetic mechanisms that govern Sp7 gene activation reveals a hierarchical process where regulatory components mediating DNA demethylation play a leading role
SP7 gene promoter is robustly enriched in epigenetic repressive marks that may explain its poor transcriptional response to osteoblast differentiating media in umbilical cord derived mesenchymal stem cells.
Eight and five of the nine samples were negative for cell adhesion molecule 1 (zeige CADM1 Proteine) and Osterix respectively. The other markers showed no statistical significance(CD151 (zeige CD151 Proteine),ALP (zeige ALP Proteine)). osteoblastic differentiation can occur in carcinoma cells and that cell adhesion molecule 1 (zeige CADM1 Proteine) could be a useful marker for identifying this phenomenon in carcinoma tissues
The results suggest that Osterix plays an important role in increasing BMP- 4 (zeige BMP4 Proteine)-induced Cx43 (zeige GJA1 Proteine) activity.
The expression of specific targets Smad1 (zeige GARS Proteine) and Osterix was significantly increased in the presence of Pi and restored by coincubation with Mg(2 (zeige MUC7 Proteine)+). As miR (zeige MLXIP Proteine)-30b, miR (zeige MLXIP Proteine)-133a, and miR (zeige MLXIP Proteine)-143 are negatively regulated by Pi and restored by Mg(2 (zeige MUC7 Proteine)+) with a congruent modulation of their known targets Runx2 (zeige RUNX2 Proteine), Smad1 (zeige GARS Proteine), and Osterix, our results provide a potential mechanistic explanation of the observed upregulation of these master switches of o
In zebrafish lacking sp7, attachment bone is never present, independent of the stage of tooth development or fish age, yet replacement is not interrupted. There was abnormal orientation of teeth, and abnormal connection of pulp cavities of predecessor and replacement teeth, arrested dentinogenesis, non-polarization of odontoblasts and only a thin layer of dentin deposition.
Sp7 plays a critical role in limiting the level of signaling and the rate of bone growth
FGF and Wnt (zeige WNT2 Proteine)/beta-Catenin (zeige CTNNB1 Proteine) pathways act in part by directing transcription of osx to promote osteoblast differentiation at sites of bone formation.
Data show the endogenous sp7 gene expression in the otic placode and vesicle, and in forming skeletal structures in Tg(sp7:EGFP)b1212 line.
this study shows that Osterix represses adipogenesis by negatively regulating PPARgamma (zeige PPARG Proteine) transcriptional activity
these findings strongly suggest that TGF-beta (zeige TGFB1 Proteine) signaling plays a major role as one of the upstream regulators of Osx in cementoblast differentiation and cementum formation
These results suggest proliferation and maturation of immature osteoblasts requires Tgfbr2 (zeige TGFBR2 Proteine) signaling and that decreased bone volume in Osx-Cre;Tgfbr2 (zeige TGFBR2 Proteine)(fl/fl (zeige FLT3LG Proteine)) mice is likely due to fewer mature osteoblasts.
DNA damage and senescence in osteoprogenitors expressing Osx may cause their decrease with age.
The data support a model in which Dlx recruitment of Sp7 to osteoblast enhancers underlies Sp7-directed osteoblast specification.
Mmp13 (zeige MMP13 Proteine) is selectively regulated of by 1,25-Dihydroxyvitamin D3, PTH (zeige PTH Proteine), and Osterix through distal enhancers.
These results indicated that olfactory bulb development was not significantly impaired in the absence of Osx.
Wnt3a (zeige WNT3A Proteine) induces Osx expression via p38 MAPK (zeige MAPK14 Proteine) signaling in dental follicle cells. Wnt3a (zeige WNT3A Proteine)-induced Osx expression was inhibited in the presence of p38 mitogen-activated protein kinase (zeige MAPK14 Proteine) (MAPK (zeige MAPK1 Proteine)) inhibitors (SB203580 and SB202190) at gene and protein levels, as assessed by real-time PCR and immunocytohistochemistry, respectively.
Transfection assay demonstrated that Osx was able to activate Bsp (zeige KLK6 Proteine) promoter reporter in a dose-dependent manner. To define minimal region of Bsp (zeige KLK6 Proteine) promoter activated by Osx, a series of deletion mutants of Bsp (zeige KLK6 Proteine) promoter were generated, and the minimal region was narrowed down to the proximal 100 bp. Point-mutagenesis studies showed that one GC-rich (zeige RELB Proteine) site was required for Bsp (zeige KLK6 Proteine) promoter activation by Osx.
OSX served a key role in the development and progression of ALD-induced VSMC calcification. This observation may aid in the explanation of the role of OSX in the pathogenesis of vascular calcification
This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein is a bone specific transcription factor and is required for osteoblast differentiation and bone formation.
transcription factor Sp7
, zinc finger protein osterix
, transcription factor osterix
, Sp7 transcription factor
, transcription factor Sp7-like
, trans-acting transcription factor 7
, Sp7 transcription factor 7