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Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. Zusätzlich bieten wir Ihnen Somatostatin Receptor 2 Antikörper (89) und Somatostatin Receptor 2 Kits (14) und viele weitere Produktgruppen zu diesem Protein an.
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The results of this study showed the SSTR2 expression was lower in patients pretreated with LA-SSA (zeige TRIM21 Proteine)/PEGV compared to the drug-naive acromegalic patients.
IHC of SSTR (zeige SSTR3 Proteine) subtypes in the different cohorts showed SSTR2 staining intensity scores higher than SSTR5 (zeige SSTR5 Proteine) in TSHoma, acromegaly and prolactinoma, whereas the expression of SSTR5 (zeige SSTR5 Proteine) was stronger than SSTR2 in corticotropinoma and NFPA.
SSTR2 was significantly hypermethylated in colorectal cancer tissues when compared with adjacent normal colorectal tissues.
This study investigated the presence of progenitor/stem cells in non-functioning pituitary tumors (NFPTs) and tested the efficacy of dopamine receptor type 2 (DRD2 (zeige DRD2 Proteine)) and somatostatin receptor type 2 (SSTR2) agonists to inhibit in vitro proliferation
expression of MDM2 (zeige MDM2 Proteine), somatostatin (zeige SST Proteine) receptor 2A, and PD-L1 (zeige CD274 Proteine) in follicular dendritic cell sarcoma
Combination treatment increased both SSTR2 and SSTR5 (zeige SSTR5 Proteine) mRNA and protein levels in DU-145 cells. The data suggest that this combination therapy may be a good candidate for patients with advanced metastatic Prostate cancer (PCa (zeige FLVCR1 Proteine)) do not respond to androgen deprivation.
although the limited number of cases with adequate term follow-up, SSTR (zeige SSTR3 Proteine)-2A expression could be a prognostic factor and somatostatin (zeige SST Proteine) analogs therapeutic candidate for SmCCs of the bladder as these tumors show high percentage of SSTR (zeige SSTR3 Proteine)-2A expression
SSTR2 expression was tested in GH-secreting adenomas from 60 patients with acromegaly who had undergone pituitary surgery, 36 of whom had received octreotide with varying levels of response. Its expression was not correlated with baseline or post-octreotide GH or IGF-1 (zeige IGF1 Proteine) levels or tumor volume.
Filamin-A (zeige FLNA Proteine) is required to mediate SSTR2 effects in pancreatic neuroendocrine tumours
Data showed that the distribution of somatostatin (zeige SST Proteine) receptor (SSTR (zeige SSTR3 Proteine)) subtypes among the 199 pancreatic neuroendocrine tumors (PNETs) was: SSTR2 (54.8%), SSTR1 (zeige SSTR1 Proteine) (53.3%), SSTR4 (51.8%), SSTR5 (zeige SSTR5 Proteine) (33.7%), and SSTR3 (zeige SSTR3 Proteine) (28.6%).
Both hippocampal sst2 and sst4 receptors selectively inhibit stress-induced HPA (zeige HPSE Proteine) axis activation but mediate anxiolytic and antidepressive effects through distinct mechanisms.
Loss of sst2 from pancreatic tissues activates PI3K signaling via AKT (zeige AKT1 Proteine), leading to activation of NF-kappaB (zeige NFKB1 Proteine), amplification of oncogenic KRAS signaling, increased expression of CXCL16 (zeige CXCL16 Proteine), and pancreatic tumor formation.
The expression and localization of the three receptors (SSTR3 (zeige SSTR3 Proteine)-SSTR5 (zeige SSTR5 Proteine)) in wild-type (WT), single-knockout (SSTR1 (zeige SSTR1 Proteine) KO) and double-knockout SSTR1 (zeige SSTR1 Proteine)/SSTR2 (DKO) mice, are reported.
SST2 expression protects against gentamicin-induced auditory hair cell loss in the mammalian inner ear.
Knock-down of SSTR2 leads to loss of pluripotency in murine embryonic stem cells.
Inhibition of the Sstr2 receptor reversed the anticonvulsant effect mediated by cortistatin-14 (zeige CORT Proteine).
OCT (zeige Plxna2 Proteine)-P407 induces mRNA expression of SSTR-2 and caspase-3 (zeige CASP3 Proteine) and decreases that of VEGF (zeige VEGFA Proteine) in mice.
The study encourages the use of liver tissue SSR2 (zeige SSR2 Proteine) protein and mRNA as a reliable tumor marker for liver cancer
when activated by SST (zeige SST Proteine)-14, SSTR2A internalizes and recycles via the Golgi, which requires ECE-1 (zeige ECE1 Proteine) degradation of SST (zeige SST Proteine)-14 and receptor dissociation from beta-arrestins
Findings suggest that somatostatin (zeige SST Proteine) and its receptors (SSTR2 and SSTR5 (zeige SSTR5 Proteine)) are important markers in the regulation and development of Sertoli cell.
Follicle-stimulating hormone regulates the SSTR2 protein expression in bovine granulosa cells.
SRIF (zeige SST Proteine) can inhibit testosterone secretion through the sst2A receptor; local inhibitory action of SRIF (zeige SST Proteine) is probably autocrine & might involve testosterone-induced increase of sst2 receptor expression in immature Leydig cells [SST2A]
Data demonstrate that urotensin II (zeige UTS2 Proteine) and urotensin II-related peptide directly activate somatostatin (zeige SST Proteine) receptors 2 and 5 and thus mimic the effect of somatostatin (zeige SST Proteine) on its cognate receptors.
Somatostatin (zeige SST Proteine) directly promoted spontaneous contractions of the circular muscle of macaque intestine via mediation of SSTR2 in myenteric nerve plexus between the longitudinal and the circular muscle.
5-HT(1A (zeige HTR1A Proteine)), SST (zeige SST Proteine)(1), and SST (zeige SST Proteine)(2) receptors mediate nonadrenergic IPSPs in the noncholinergic (VIP (zeige Vip Proteine)) secretomotor neurons of the submucous plexus of the guinea pig ileum.
Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR2 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in cerebrum and kidney.
, somatostatin receptor type 2
, somatostatin receptor subtype 2
, somatotropin release-inhibiting factor receptor
, somatostatin receptor 2
, somatostatin type 2 receptor
, somatostatin receptor type 2-like