Solute Carrier Family 14 (Urea Transporter), Member 1 (Kidd Blood Group) Proteine (SLC14A1)

The protein encoded by SLC14A1 is a membrane transporter that mediates urea transport in erythrocytes. Zusätzlich bieten wir Ihnen Solute Carrier Family 14 (Urea Transporter), Member 1 (Kidd Blood Group) Antikörper (55) und Solute Carrier Family 14 (Urea Transporter), Member 1 (Kidd Blood Group) Kits (10) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
SLC14A1 6563 Q13336
Maus SLC14A1 SLC14A1 108052 Q8VHL0
Ratte SLC14A1 SLC14A1 54301 P97689
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Anmelden zum Anzeigen 50 bis 55 Tage
$7,493.38
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 11 Days
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
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SLC14A1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,

Am meisten referenzierte Solute Carrier Family 14 (Urea Transporter), Member 1 (Kidd Blood Group) Proteine

  1. Human SLC14A1 Protein expressed in HEK-293 Cells - ABIN2732146 : Walpole, Farrell, McGrane, Stewart: Expression and localization of a UT-B urea transporter in the human bladder. in American journal of physiology. Renal physiology 2014 (PubMed)

Weitere Proteine zu Solute Carrier Family 14 (Urea Transporter), Member 1 (Kidd Blood Group) (SLC14A1) Interaktionspartnern

Human Solute Carrier Family 14 (Urea Transporter), Member 1 (Kidd Blood Group) (SLC14A1) Interaktionspartner

  1. Study found that UT-B expression is decreased in human melanoma tissue. Its overexpression plays a role in tumor growth regulation of melanoma cell lines and animal transplantation models, and this, combined with findings from UT-B inhibition in bladder cancer, suggests that UT-B may have tumor suppressor functions.

  2. The urea transporter subtypes, UT-A1 and UT-B1, were expressed in the skin basal cell layer and exocrine sweat glands. The abundance of UT-A1 and UT-B1 in uremic sweat glands was significantly increased in UP, while the expression of AQP5 was decreased.

  3. In addition to the well known Polynesian Jknull allele, three Jknull alleles were detected including one novel Jknull allele: JKA (130A, 220G).

  4. The Jk(a-b-) phenotype in the Chinese population shows several different molecular mechanisms. A novel missense mutation nt737T>G of JK gene was found as associated with Jk(a-b-) phenotype.

  5. Data indicate that urea transporter UT-A1 successfully trafficking to the apical membrane of the epithelial cells is crucial for the regulation of urea transport.

  6. Results suggested that polymorphism in TERTC/T and SLC14A1C/T confirmed high risk for BC in North Indian population.

  7. Reduction or loss of UT-B expression may be related to the incidence, progression and invasiveness of bladder urothelial carcinoma.

  8. Studies indicate that expression of urea transporter UT-B confers high urea permeability to erythrocytes.

  9. Studies indicate that acid substitution in the urea transporter Slc14A1 UT-B protein determines the erythrocyte Kidd blood group antigen.

  10. UT-B should be considered as a new member of the water channel family.

  11. High-throughput Kell, Kidd, and Duffy matrix-assisted laser desorption/ionization, time-of-flight mass spectrometry-based blood group genotyping of 4000 donors shows close to full concordance with serotyping and detects new alleles.

  12. these data confirm the presence of UT-B protein within the human bladder.

  13. Novel polymorphisms in exon 9 of the JSLC14A1 gene in Japanese individuals associated with the Jk(a-b-) phenotype.

  14. Thienoquinoline PU-14 is a selective UT inhibitor and has urea-selective diuretic activity.

  15. SLC14A1 could be a unique urea transporter in the bladder that has the ability to influence urine concentration and that this mechanism might explain the increased bladder cancer susceptibility associated with rs10775480.

  16. Inhibitor and mutagenesis studies and results of molecular dynamics simulations suggest that NH and HO pass through the three monomeric urea channels in UT-B.

  17. Four novel JK-null alleles were noted to be associated with the Jk(a-b-) phenotype.

  18. the rate of urea conduction in UT-B is increased by hypoosmotic stress, and the site of osmoregulation coincides with the location of the energy barrier

  19. Loss of SLC14A1 is associated with lung adenocarcinoma.

  20. rs17674580, or other sequence variants of SLC14A1, indirectly modifies urinary bladder cancer risk by affecting urine production.

Mouse (Murine) Solute Carrier Family 14 (Urea Transporter), Member 1 (Kidd Blood Group) (SLC14A1) Interaktionspartner

  1. functional deficiency of all UTs caused a urea-selective urine-concentrating defect with little physiological abnormality in extrarenal organs.

  2. We conclude that transgenic expression of UT-A1 restores basal urea permeability to the level in wild-type mice but does not restore vasopressin-stimulated levels of urea permeability. This information suggests that transgenic expression of UT-A1 alone in mice lacking UT-A1 and UT-A3 is sufficient to restore urine-concentrating ability

  3. These results demonstrate that the descending thin limb (DTL) of the intermediate loop is composed of type I epithelium and expresses both UT-A2. The functional role of the DTL of the intermediate loop may be distinct from the short or long loops.

  4. Studies indicate that expression of urea transporter UT-B confers high urea permeability to erythrocytes.

  5. Studies indicate that urea transporter Slc14a1 UT-B is an indispensable transporter involved in maintaining physiological functions in different tissues.

  6. Data suggest that urea transporter UT-B may play an important role in protecting bladder urothelium by balancing intracellular urea concentration.

  7. Thienoquinoline PU-14 is a selective UT inhibitor and has urea-selective diuretic activity.

  8. AQP9 and unidentified UT-A urea channels constitute primary but redundant urea facilitators in murine hepatocytes

  9. Urea transporter-B-null mice showed defective urine concentrating ability.

  10. UT-B null mice exhibited depression-like behavior, with urea accumulation, nitric oxide reduction, and selective neuronal nitric oxide synthase level increase in hippocampus.

  11. UT-A2 deletion in UT-B knockout mice partially remedies the urine concentrating defect caused by UT-B deletion.

  12. UT-B has a role in urinary concentrating ability in mice

  13. potassium depletion is associated with reduced expression of UT-A1, UT-A3, and UT-B but increased expression of UT-A2

  14. UT-B-deficient mice reveal that countercurrent exchange of urea in renal medullary vessels and red blood cells accounts for a major part of the kidney's concentrating ability and for the adaptation of renal urea handling during a high-protein intake.

  15. UT-B null mice have a normal glomerular filtration rate but moderately reduced urea clearance

  16. This review focuses on the erythrocyte urea transporter UT-B.

  17. UT-B plays an important role in eliminating urea produced by Sertoli cells and UT-B deletion causes both urea accumulation in the testis and early maturation of the male reproductive system.

  18. Data indicate that UT-B deletion caused the dynamic expression regulation of TNNT2 and ANP, and these proteins may provide new clues to investigate the molecular events involved in cardiac conduction.

  19. Results provide the first evidence that UT-B deletion causes progressive heart block in mice.

Cow (Bovine) Solute Carrier Family 14 (Urea Transporter), Member 1 (Kidd Blood Group) (SLC14A1) Interaktionspartner

  1. Data suggest that expression of UT-B (urea transporter B) in rumen mucosa can be modulated by dietary factors; here, UT-B and AQP3 (aquaglyceroporin-3) expression are upregulated with solid food intake (low-protein diet of plant forage) at weaning.

  2. the rate of urea conduction in UT-B is increased by hypoosmotic stress, and the site of osmoregulation coincides with the location of the energy barrier

  3. Bovine UT-B is expressed in bovine rumen and may function to transport urea into rumen as part of ruminant urea nitrogen salvaging process.

Solute Carrier Family 14 (Urea Transporter), Member 1 (Kidd Blood Group) (SLC14A1) Protein Überblick

Protein Überblick

The protein encoded by this gene is a membrane transporter that mediates urea transport in erythrocytes. This gene forms the basis for the Kidd blood group system.

Genbezeichner und Symbole assoziert mit SLC14A1

  • solute carrier family 14 member 1 (Kidd blood group) (SLC14A1)
  • solute carrier family 14 (urea transporter), member 1 (Slc14a1)
  • solute carrier family 14 member 1 (Slc14a1)
  • 2610507K20Rik Protein
  • 3021401A05Rik Protein
  • HsT1341 Protein
  • HUT11 Protein
  • JK Protein
  • RACH1 Protein
  • RACH2 Protein
  • UrT2 Protein
  • UT-1 Protein
  • UT-B Protein
  • UT-B1 Protein
  • UT1 Protein
  • UT3 Protein
  • UTB1 Protein
  • UTE Protein

Bezeichner auf Proteinebene für SLC14A1

Kidd blood group , SLC14A1 JK , solute carrier family 14 (urea transporter), member 1 (Kidd blood group) , urea transporter 1 , urea transporter JK glycoprotein , urea transporter, erythrocyte , urea transporter-B1 , solute carrier family 14 member 1 , urea transporter B , Solute carrier family 14 member 1 , Urea transporter 1 , Urea transporter, erythrocyte , Urea transporter B

GENE ID SPEZIES
6563 Homo sapiens
108052 Mus musculus
54301 Rattus norvegicus
490470 Canis lupus familiaris
493988 Bos taurus
100860878 Capra hircus
100302356 Ovis aries
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