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The protein encoded by SLC14A1 is a membrane transporter that mediates urea transport in erythrocytes.
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Human SLC14A1 Protein expressed in HEK-293 Cells - ABIN2732146
Walpole, Farrell, McGrane, Stewart: Expression and localization of a UT-B urea transporter in the human bladder. in American journal of physiology. Renal physiology 2014
Data indicate that urea transporter UT-A1 successfully trafficking to the apical membrane of the epithelial cells is crucial for the regulation of urea transport.
Reduction or loss of UT-B expression may be related to the incidence, progression and invasiveness of bladder urothelial carcinoma.
Studies indicate that expression of urea transporter UT-B confers high urea permeability to erythrocytes.
Studies indicate that acid substitution in the urea transporter Slc14A1 UT-B protein (zeige LEPREL2 Proteine) determines the erythrocyte Kidd blood group antigen (zeige DARC Proteine).
UT-B should be considered as a new member of the water channel (zeige AQP4 Proteine) family.
High-throughput Kell, Kidd, and Duffy matrix-assisted laser desorption/ionization, time-of-flight mass spectrometry-based blood group (zeige DARC Proteine) genotyping of 4000 donors shows close to full concordance with serotyping and detects new alleles.
these data confirm the presence of UT-B protein (zeige LEPREL2 Proteine) within the human bladder.
SLC14A1 could be a unique urea transporter in the bladder that has the ability to influence urine concentration and that this mechanism might explain the increased bladder cancer susceptibility associated with rs10775480.
Inhibitor and mutagenesis studies and results of molecular dynamics simulations suggest that NH and HO pass through the three monomeric urea channels in UT-B.
the rate of urea conduction in UT-B is increased by hypoosmotic stress, and the site of osmoregulation coincides with the location of the energy barrier
We conclude that transgenic expression of UT-A1 restores basal urea permeability to the level in wild-type mice but does not restore vasopressin-stimulated levels of urea permeability. This information suggests that transgenic expression of UT-A1 alone in mice lacking UT-A1 and UT-A3 is sufficient to restore urine-concentrating ability
These results demonstrate that the descending thin limb (DTL (zeige DTL Proteine)) of the intermediate loop is composed of type I epithelium and expresses both UT-A2. The functional role of the DTL (zeige DTL Proteine) of the intermediate loop may be distinct from the short or long loops.
Studies indicate that urea transporter Slc14a1 UT-B is an indispensable transporter involved in maintaining physiological functions in different tissues.
Data suggest that urea transporter UT-B may play an important role in protecting bladder urothelium by balancing intracellular urea concentration.
AQP9 (zeige AQP9 Proteine) and unidentified UT-A urea channels constitute primary but redundant urea facilitators in murine hepatocytes
Urea transporter-B-null mice showed defective urine concentrating ability.
UT-B null mice exhibited depression-like behavior, with urea accumulation, nitric oxide reduction, and selective neuronal nitric oxide synthase (zeige NOS1 Proteine) level increase in hippocampus.
UT-A2 deletion in UT-B knockout mice partially remedies the urine concentrating defect caused by UT-B deletion.
UT-B has a role in urinary concentrating ability in mice
Data suggest that expression of UT-B (urea transporter B) in rumen mucosa can be modulated by dietary factors; here, UT-B and AQP3 (aquaglyceroporin-3 (zeige AQP3 Proteine)) expression are upregulated with solid food intake (low-protein diet of plant forage) at weaning.
Bovine UT-B is expressed in bovine rumen and may function to transport urea into rumen as part of ruminant urea nitrogen salvaging process.
The protein encoded by this gene is a membrane transporter that mediates urea transport in erythrocytes. This gene forms the basis for the Kidd blood group system.
Kidd blood group
, SLC14A1 JK
, solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
, urea transporter 1
, urea transporter JK glycoprotein
, urea transporter, erythrocyte
, urea transporter-B1
, solute carrier family 14 member 1
, urea transporter B
, Solute carrier family 14 member 1
, Urea transporter 1
, Urea transporter, erythrocyte
, Urea transporter B