anti-Sodium Channel, Voltage-Gated, Type XI, alpha Subunit (SCN11A) Antikörper

This protein mediates the voltage-dependent sodium ion permeability of excitable membranes.

Alle Antikörper anzeigen	Gen	GeneID	UniProt
Anti-Maus SCN11A	SCN11A	24046	Q9R053
Anti-Ratte SCN11A	SCN11A	29701	O88457
Anti-Human SCN11A	SCN11A	11280	Q9UI33

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Top anti-Sodium Channel, Voltage-Gated, Type XI, alpha Subunit Antikörper auf antikoerper-online.de

Showing 10 out of 21 products:

Katalog Nr.	Reaktivität	Wirt	Konjugat	Applikation	Menge	Anbieter	Lieferzeit	Preis	Details
ABIN394475	Human	Maus	Unkonjugiert	ELISA, WB	0.1 mg	Anmelden zum Anzeigen	8 bis 11 Tage	$450.00	Details
ABIN564905	Human	Maus	Unkonjugiert	ELISA, WB	100 μg	Anmelden zum Anzeigen	11 bis 12 Tage	$440.00	Details
ABIN350851	Human	Kaninchen	Unkonjugiert	IHC, WB	100 μL	Anmelden zum Anzeigen	7 bis 8 Tage	$454.67	Details
ABIN350852	Maus	Kaninchen	Unkonjugiert	IHC	100 μL	Anmelden zum Anzeigen	7 bis 8 Tage	$454.67	Details
ABIN4352244	Human	Kaninchen	Unkonjugiert	IHC, IHC (p)	0.1 mL	Anmelden zum Anzeigen	10 bis 13 Tage	$491.63	Details
ABIN797781	Human	Kaninchen	Unkonjugiert	IHC, WB	100 μL	Anmelden zum Anzeigen	7 bis 9 Tage	$551.83	Details
ABIN4352245	Human	Kaninchen	Unkonjugiert	IHC	0.1 mL	Anmelden zum Anzeigen	10 bis 13 Tage	$491.63	Details
ABIN6114161	Human	Kaninchen	HRP	ELISA	100 μg	Anmelden zum Anzeigen	11 bis 18 Tage	$412.19	Details
ABIN6114163	Human	Kaninchen	FITC	ELISA	100 μg	Anmelden zum Anzeigen	11 bis 18 Tage	$412.19	Details
ABIN6114165	Human	Kaninchen	Biotin	ELISA	100 μg	Anmelden zum Anzeigen	11 bis 18 Tage	$412.19	Details

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Weitere Antikörper gegen Sodium Channel, Voltage-Gated, Type XI, alpha Subunit Interaktionspartner

Mouse (Murine) Sodium Channel, Voltage-Gated, Type XI, alpha Subunit (SCN11A) Interaktionspartner

This study demonstrated that NaV1.9 presumably contributes to acute thermal and mechanical nociception in mice.
These results demonstrate that Nav1.9 channels play a critical role in the development of orofacial neuropathic pain.
Recently Nav1.9, a voltage-gated sodium channel subtype, has been established as a genetic influence for certain peripheral pain syndromes.
A missense mutation (p.V1184A) in NaV1.9 leads to cold-aggravated peripheral pain.
We conclude that Nav1.9 acts as a subthreshold amplifier in cold-sensitive nociceptive neurons and is required for the perception of cold pain under normal and pathological conditions.
NaV1.9 is required for persistence of responses to intense mechanical stimulation, contributes to inflammatory mechanical hypersensitivity, and is essential for activation by noxious inflammatory mediators, including those from diseased human bowel.
The results strongly suggested that Nav1.9 was expressed and functionally contributed to the signaling processing in the central auditory pathway.
Axon growth of NaV1.9-deficient motoneurons in cell culture is drastically reduce.
In the stable NaV1.9-deficient cells we successfully constructed, proliferation, phagocytosis and migration were obviously inhibited.
Na(V)1.9 function appears to be essential for activity-dependent axon growth in motor neurons, acting upstream of spontaneous Ca(2 (zeige CA2 Antikörper)+) elevation through voltage-gated calcium channels.

Human Sodium Channel, Voltage-Gated, Type XI, alpha Subunit (SCN11A) Interaktionspartner

We identified a missense mutation of p.Arg225Cys in SCN11A in a four-generation Chinese family with early-onset familial episodic pain and adult onset familial essential tremor syndrome.
SCN11A single-nucleotide polymorphisms affect Postoperative pain sensitivity in Chinese Han women after Gynecological surgery. The SNP rs33985936 and rs13080116 may serve as novel predictors for Postoperative pain.
a U-shaped relationship between the resting potential and the neuronal action potential threshold explains why NaV1.9 mutations that evoke small degrees of membrane depolarization cause hyperexcitability and familial episodic pain disorder or painful neuropathy, while mutations evoking larger membrane depolarizations cause hypoexcitability and insensitivity to pain.
Recently Nav1.9, a voltage-gated sodium channel subtype, has been established as a genetic influence for certain peripheral pain syndromes.
Results show the expression of Nav1.9 channels within the human colon for the first time. Furthermore, Nav1.9 channel expression is decreased in Hirschsprung's disease versus normal controls.
autosomal dominant Congenital insensitivity to pain reflects the second gain-of-function mutation of SCN11A.
A missense mutation (p.V1184A) in NaV1.9 leads to cold-aggravated peripheral pain.
A G699R substitution in the Nav1.9 domain II S4-S5 linker renders dorsal root ganglion neurons hyperexcitable, via depolarized resting membrane potential, reduced current threshold and increased evoked firing in small-fiber neuropathy.
missense mutations of Nav1.9 in individuals with painful peripheral neuropathy
The results demonstrate that Nav1.8 (zeige SCN10A Antikörper) and Nav1.9 are present in human lingual nerve neuromas, with significant correlations between the level of expression of Nav1.8 (zeige SCN10A Antikörper) and symptoms of pain.

Sodium Channel, Voltage-Gated, Type XI, alpha Subunit (SCN11A) Antigen-Profil

Protein Überblick

This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Also involved, with the contribution of the receptor tyrosine kinase NTRK2, in rapid BDNF-evoked neuronal depolarization (By similarity).

Genbezeichner und Symbole assoziert mit SCN11A

sodium voltage-gated channel alpha subunit 11 (SCN11A) Antikörper
sodium channel protein type 11 subunit alpha (LOC100349709) Antikörper
sodium channel, voltage-gated, type XI, alpha (Scn11a) Antikörper
sodium voltage-gated channel alpha subunit 11 (Scn11a) Antikörper

NaN Antikörper
NaT Antikörper
NAV1.9 Antikörper
NSS2 Antikörper
SCN11A Antikörper
SCN12A Antikörper
SNS-2 Antikörper
SNS2 Antikörper

Bezeichner auf Proteinebene für SCN11A

sodium channel, voltage-gated, type XI, alpha subunit , sodium channel protein type 11 subunit alpha-like , sensory neuron sodium channel 2 , sodium channel protein type 11 subunit alpha , sodium channel protein type XI subunit alpha , sodium channel, voltage-gated, type XI, alpha polypeptide , voltage-gated sodium channel NAV1.9b , voltage-gated sodium channel subunit alpha Nav1.9 , sodium channel voltage-gated type 11 alpha polypeptide , sodium channel voltage-gated type XI alpha polypeptide , sodium channel, voltage-gated, type 11, alpha polypeptide , sodium channel, voltage-gated, type11, alpha polypeptide , PN5 , hNaN , peripheral nerve sodium channel 5 , sodium channel, voltage-gated, type XII, alpha polypeptide , voltage-gated sodium channel Nav1.9

GENE ID	SPEZIES
460275	Pan troglodytes
100349709	Oryctolagus cuniculus
100414951	Callithrix jacchus
100464374	Ailuropoda melanoleuca
100601668	Nomascus leucogenys
24046	Mus musculus
29701	Rattus norvegicus
11280	Homo sapiens
485593	Canis lupus familiaris
100739142	Sus scrofa
535956	Bos taurus

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