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Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride.
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Human Polyclonal SCNN1D Primary Antibody für ELISA - ABIN4243306
Giraldez, Afonso-Oramas, Cruz-Muros, Garcia-Marin, Pagel, González-Hernández, Alvarez de la Rosa: Cloning and functional expression of a new epithelial sodium channel delta subunit isoform differentially expressed in neurons of the human and monkey telencephalon. in Journal of neurochemistry 2007
The Epithelial Sodium Channel Is a Modifier of the Long-Term Nonprogressive Phenotype Associated with F508del CFTR (zeige CFTR Antikörper) Mutations
deltabetagamma-ENaC (zeige SCNN1A Antikörper) is inhibited by CFTR (zeige CFTR Antikörper) but activated by cyclic AMP (zeige APRT Antikörper).
delta-ENaC expression is low in NCI-H441, Calu (zeige CALU Antikörper)-3, and ATI cells and does not contribute to transepithelial sodium absorption
study characterized a new variant, delta2 ENaC (zeige SCNN1A Antikörper), in lung epithelial cells; heterologous delta2betagamma ENaC (zeige SCNN1A Antikörper) exhibited a number of divergent features from the delta1betagamma counterpart in biophysics and pharmacology, regulation, and the lifespan of proteins
delta-ENaC undergoes dynamin (zeige DNM1 Antikörper)-independent endocytosis as opposed to alphabetagamma-channels.
These results suggest that COMMD1 downregulates deltaENaC activity by reducing deltaENaC surface expression through promoting internalization of surface deltaENaC to an intracellular recycling pool, possibly via enhanced ubiquitination.
Cpt (zeige CHPT1 Antikörper)-cAMP activates human epithelial sodium channels via relieving self-inhibition.
CPT (zeige CHPT1 Antikörper)-cGMP Stimulates Human Alveolar Fluid Clearance by Releasing External Na+ Self-Inhibition of ENaC (zeige SCNN1A Antikörper).
Data support a physiological role for SGK1.1 in the regulation of delta-ENaC through a pathway that differs from the classical one and suggest that the kinase could serve as an integrator of different signaling pathways converging on the channel.
delta ENaC is regulated by Murr1 (zeige COMMD1 Antikörper)
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception (By similarity).
sodium channel, nonvoltage-gated 1, delta
, amiloride-sensitive sodium channel subunit delta
, epithelial Na(+) channel subunit delta
, nonvoltage-gated sodium channel 1 subunit delta
, sodium channel, voltage-gated, type I, delta polypeptide
, epithelial sodium channel delta subunit