Sex Comb On Midleg-Like 2 (Drosophila) Proteine (SCML2)

SCML2 encodes a member of the Polycomb group proteins. Zusätzlich bieten wir Ihnen SCML2 Antikörper (44) und und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
SCML2 10389 Q9UQR0
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Showing 3 out of 3 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$9,797.11
Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 2 bis 3 Tage
$814.00
Details

SCML2 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,

Weitere Proteine zu Sex Comb On Midleg-Like 2 (Drosophila) (SCML2) Interaktionspartnern

Human Sex Comb On Midleg-Like 2 (Drosophila) (SCML2) Interaktionspartner

  1. SCML2A, an SCML2 isoform tightly associated to chromatin, contributes to PRC1 (zeige PRC1 Proteine) localization and also directly enforces repression of certain Polycomb (zeige CBX2 Proteine) target genes.

  2. SCML2 directly interacts with USP7 (zeige USP7 Proteine) and drives its localization. SCML2 connects USP7 (zeige USP7 Proteine) to PRC1.4, allowing for the stabilization of BMI1 (zeige BMI1 Proteine), and USP7 (zeige USP7 Proteine) is found on SCML2 and BMI1 (zeige BMI1 Proteine) target genes.

  3. Because PRC1 (zeige PRC1 Proteine) complexes localize to the promoters of a specific subset of developmental genes in vivo, the SLED domain of Scml2 may provide an important link connecting the PRC1 (zeige PRC1 Proteine) complexes to their target genes.

  4. 1.78-A crystal structure of the two MBT (zeige PRTN3 Proteine) repeats of SCML2 show significant structural similarities to the Tudor, PWWP, and chromo domains, suggesting probable evolutionary relationships and functional similarities between the MBT (zeige PRTN3 Proteine) repeats and these domains.

  5. The malignant brain tumor repeats of SCML2 preferentially bind histone peptides monomethylated at lysine residues. The crystal structure of the complex reveals that the modified amino acid binds to an aromatic rich pocket.

SCML2 Protein Überblick

Protein Überblick

This gene encodes a member of the Polycomb group proteins. These proteins form the Polycomb repressive complexes which are involved in transcriptional repression. The encoded protein binds histone peptides that are monomethylated at lysine residues and may be involved in regulating homeotic gene expression during development.

Genbezeichner und Symbole assoziert mit SCML2

  • Scm polycomb group protein like 2 (SCML2)

Bezeichner auf Proteinebene für SCML2

sex comb on midleg-like protein 2

GENE ID SPEZIES
10389 Homo sapiens
Ausgewählte Anbieter für SCML2 Proteine (SCML2)
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