Sex Comb On Midleg-Like 2 (Drosophila) Proteine (SCML2)

SCML2 encodes a member of the Polycomb group proteins. Zusätzlich bieten wir Ihnen SCML2 Antikörper (42) und und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
SCML2 10389 Q9UQR0
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Top SCML2 Proteine auf

Showing 3 out of 3 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 11 Days

SCML2 Proteine nach Spezies und Herkunft

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Human , ,
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Weitere Proteine zu Sex Comb On Midleg-Like 2 (Drosophila) (SCML2) Interaktionspartnern

Human Sex Comb On Midleg-Like 2 (Drosophila) (SCML2) Interaktionspartner

  1. SCML2A, an SCML2 isoform tightly associated to chromatin, contributes to PRC1 localization and also directly enforces repression of certain Polycomb target genes.

  2. SCML2 directly interacts with USP7 and drives its localization. SCML2 connects USP7 to PRC1.4, allowing for the stabilization of BMI1, and USP7 is found on SCML2 and BMI1 target genes.

  3. Because PRC1 complexes localize to the promoters of a specific subset of developmental genes in vivo, the SLED domain of Scml2 may provide an important link connecting the PRC1 complexes to their target genes.

  4. 1.78-A crystal structure of the two MBT repeats of SCML2 show significant structural similarities to the Tudor, PWWP, and chromo domains, suggesting probable evolutionary relationships and functional similarities between the MBT repeats and these domains.

  5. The malignant brain tumor repeats of SCML2 preferentially bind histone peptides monomethylated at lysine residues. The crystal structure of the complex reveals that the modified amino acid binds to an aromatic rich pocket.

SCML2 Protein Überblick

Protein Überblick

This gene encodes a member of the Polycomb group proteins. These proteins form the Polycomb repressive complexes which are involved in transcriptional repression. The encoded protein binds histone peptides that are monomethylated at lysine residues and may be involved in regulating homeotic gene expression during development.

Genbezeichner und Symbole assoziert mit SCML2

  • Scm polycomb group protein like 2 (SCML2)

Bezeichner auf Proteinebene für SCML2

sex comb on midleg-like protein 2

10389 Homo sapiens
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