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May play a role during myoblast fusion (By similarity)..
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Human Monoclonal SLMAP Primary Antibody für IHC (p), ELISA - ABIN521687
Nader, Westendorp, Hawari, Salih, Stewart, Leenen, Tuana: Tail-anchored membrane protein SLMAP is a novel regulator of cardiac function at the sarcoplasmic reticulum. in American journal of physiology. Heart and circulatory physiology 2012
Here, the authors discover SAV1 (zeige SAV1 Antikörper)-mediated inhibition of the PP2A (zeige PPP2R4 Antikörper) complex STRIPAK(SLMAP) as a key mechanism of MST1 (zeige MST1 Antikörper)/2 activation.
The data suggests the potential role of SLMAP single nucleotide polymorphism as a risk factor for the susceptibility of diabetic retinopathy among type 2 diabetes patients in the Qatari population.
Mutations in SLMAP may cause Brugada syndrome via modulating the intracellular trafficking of hNav1.5 channel.
These data demonstrate that SLMAP is a regulator of E-C coupling at the level of the SR and its perturbation results in progressive deterioration of cardiac electrophysiology and function.
SLMAP may be an important regulator of glucose uptake or involved in GLUT-4 (zeige SLC2A4 Antikörper) fusion/translocation into the plasma membrane of mouse abdominal adipose tissue; changes in SLMAP expression are linked to hyperglycemia and diabetes.
the genomic structure; SLMAP sequences directed a reporter green fluorescent protein (GFP) to the centrosome, and deletions of the newly identified N-terminal sequence from SLMAP prevented the centrosomal targeting
The cardiac-specific expression of SLMAP isoforms that can be targeted to distinct subcellular membranes, self assemble, and interact with the myofibril suggests a potential role in the structural arrangement of the E-C coupling apparatus.
Microvasculature in db/db (zeige LEPR Antikörper) mice undergoes significant changes in vascular function with endothelial component of vascular dysfunction specifically correlating with overexpression of SLMAP.
May play a role during myoblast fusion (By similarity).
sarcolemma associated protein
, TOP AP
, sarcolemmal membrane-associated protein-like
, Sarcolemmal-associated protein
, sarcolemmal membrane-associated protein
, sarcolemmal-associated protein